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Open AccessThe protective effect of human renal sinus fat on glomerular cells is reversed by the hepatokine fetuin-A
Renal sinus fat (RSF) is a perivascular fat compartment located around renal arteries. In this in vitro and in vivo study we hypothesized that the hepatokine fetuin-A may impair renal function in non alcoholic fa...
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Article
Perivascular adipose tissue: An unique fat compartment relevant for the cardiometabolic syndrome
Type 2 diabetes and its major risk factor, obesity, are an increasing worldwide health problem. The exact mechanisms that link obesity with insulin resistance, type 2 diabetes, hypertension, cardiovascular com...
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Article
Age-dependent association of serum prolactin with glycaemia and insulin sensitivity in humans
The dopamine agonist bromocriptine has been approved for the treatment of type 2 diabetes in the United States. Bromocriptine inhibits prolactin secretion, and patients with hyperprolactinaemia display impaire...
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Article
Plasminogen activator inhibitor-1, monocyte chemoattractant protein-1, e-selectin and C-reactive protein levels in response to 4-week very-high-fructose or -glucose diets
High intake of added sweeteners is considered to have a causal role in the pathogenesis of cardiometabolic disorders. Especially, high-fructose intake is regarded as potentially harmful to cardiometabolic heal...
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Article
Insulinwirkung im menschlichen Gehirn
In den letzten Jahren ist das Gehirn als insulinsensitives Organ immer mehr in den Fokus der Forschung gerückt. Auch beim Menschen erreicht Insulin aus der Peripherie das Gehirn und führt zu spezifischen Aktiv...
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Article
Regulation of forkhead box O1 (FOXO1) by protein kinase B and glucocorticoids: different mechanisms of induction of beta cell death in vitro
In steroid diabetes insulin secretion does not adequately compensate for enhanced hepatic gluconeogenesis and peripheral insulin resistance. Previous studies suggest that activation of the transcription factor...
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Article
Exercise-induced albuminuria is associated with perivascular renal sinus fat in individuals at increased risk of type 2 diabetes
Microalbuminuria represents an established surrogate marker of early diabetic nephropathy and glomerular microangiopathy. Increasing evidence is emerging of a role of perivascular adipose tissue (PVAT) as an i...
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Article
Body adiposity index, body fat content and incidence of type 2 diabetes
The aim of this study was to compare estimates of body fat content, i.e. body adiposity index (BAI), BMI and waist and hip circumferences, with respect to their ability to predict the percentage of body fat (P...
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Article
Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and reward-related human brain regions
Impaired insulin sensitivity is a major factor leading to type 2 diabetes. Animal studies suggest that the brain is involved in the regulation of insulin sensitivity. We investigated whether insulin action in ...
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Article
Visceral obesity modulates the impact of apolipoprotein C3 gene variants on liver fat content
It has not been solved whether subjects carrying the minor alleles of the −455T>C or −482C>T single nucleotide polymorphisms (SNPs) in the apolipoprotein-C3-gene (APOC3) have an increased risk for develo** fatt...
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Article
The secretion pattern of perivascular fat cells is different from that of subcutaneous and visceral fat cells
We have previously found that the mass of perivascular adipose tissue (PVAT) correlates negatively with insulin sensitivity and post-ischaemic increase in blood flow. To understand how PVAT communicates with v...
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Article
High cerebral insulin sensitivity is associated with loss of body fat during lifestyle intervention
Loss of weight and body fat are major targets in lifestyle interventions to prevent diabetes. In the brain, insulin modulates eating behaviour and weight control, resulting in a negative energy balance. This s...
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Article
Acute, short-term hyperinsulinemia increases olfactory threshold in healthy subjects
Smell plays an important role in feeding behavior. We therefore tested whether insulin as a postprandial signal is involved in the regulation of olfactory function.
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Article
Nichtalkoholische Steatohepatitis
Die nichtalkoholische Fettlebererkrankung (NAFLD) und insbesondere die nichtalkoholische Steatohepatitis (NASH) stellen nicht nur Risikofaktoren für Leberfibrose, Leberzirrhose und das hepatozelluläre Karzinom...
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Article
Effects of a lifestyle intervention in metabolically benign and malign obesity
We and others recently characterised metabolically benign or healthy obesity (MHO). In the present study we investigated whether a lifestyle intervention is sufficient to place obese insulin-resistant (OIR) in...
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Article
Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B
The aim of this study was to investigate the association of the rs10811661 polymorphism near the CDKN2B/CDKN2A genes with glucose tolerance, insulin sensitivity and insulin release in three samples of white peopl...
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Article
BK channels affect glucose homeostasis and cell viability of murine pancreatic beta cells
Evidence is accumulating that Ca2+-regulated K+ (KCa) channels are important for beta cell function. We used BK channel knockout (BK-KO) mice to examine the role of these KCa channels for glucose homeostasis, bet...
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Article
Dissociation between fatty liver and insulin resistance: the role of adipose triacylglycerol lipase
Non-alcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance and type 2 diabetes in humans. Ongoing research aims to clarify the mechanisms involved in this relationship. Studying p...
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Article
Genetic variants affecting incretin sensitivity and incretin secretion
Recent genome-wide association studies identified several novel risk genes for type 2 diabetes. The majority of these type 2 diabetes risk variants confer impaired pancreatic beta cell function. Though the mol...
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Article
IL-6 deficiency in mice neither impairs induction of metabolic genes in the liver nor affects blood glucose levels during fasting and moderately intense exercise
Fasting and exercise are strong physiological stimuli for hepatic glucose production. IL-6 has been implicated in the regulation of gluconeogenic genes, but the results are contradictory and the relevance of I...
