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Article
Open AccessThe protective effect of human renal sinus fat on glomerular cells is reversed by the hepatokine fetuin-A
Renal sinus fat (RSF) is a perivascular fat compartment located around renal arteries. In this in vitro and in vivo study we hypothesized that the hepatokine fetuin-A may impair renal function in non alcoholic fa...
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Article
Open AccessOxytocin’s inhibitory effect on food intake is stronger in obese than normal-weight men
Animal studies and pilot experiments in men indicate that the hypothalamic neuropeptide oxytocin limits food intake, and raise the question of its potential to improve metabolic control in obesity.
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Article
Open AccessAssociation between omentin-1, adiponectin and bone health under consideration of osteoprotegerin as possible mediator
Several studies implicated a crosstalk between bone and fat in the pathogenesis of osteoporosis. Few studies indicated an association between adiponectin and omentin-1 on the bone remodeling process and bone m...
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Article
Erratum: Association between erythrocyte membrane fatty acids and biomarkers of dyslipidemia in the EPIC-Potsdam study
Correction to: European Journal of Clinical Nutrition (2014) 68, 517–525; doi:10.1038/ejcn.2014.18; published online 26 February 2014 Since publication, the authors have found an SAS coding error in the LDL-ch...
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Article
Association between erythrocyte membrane fatty acids and biomarkers of dyslipidemia in the EPIC-Potsdam study
Blood proportions of fatty acids (FAs) and FA-ratios reflecting desaturase activity are associated with the risk of chronic diseases like type 2 diabetes mellitus or cardiovascular diseases. Biomarkers of dysl...
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Article
Altered brain activity in severely obese women may recover after Roux-en Y gastric bypass surgery
Neuroimaging studies have demonstrated alterations in brain activity in obese (OB) subjects that might be causally linked to their disorder. Roux-en Y gastric bypass (RYGB) surgery induces a marked and sustain...
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Article
Age-dependent association of serum prolactin with glycaemia and insulin sensitivity in humans
The dopamine agonist bromocriptine has been approved for the treatment of type 2 diabetes in the United States. Bromocriptine inhibits prolactin secretion, and patients with hyperprolactinaemia display impaire...
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Article
Plasminogen activator inhibitor-1, monocyte chemoattractant protein-1, e-selectin and C-reactive protein levels in response to 4-week very-high-fructose or -glucose diets
High intake of added sweeteners is considered to have a causal role in the pathogenesis of cardiometabolic disorders. Especially, high-fructose intake is regarded as potentially harmful to cardiometabolic heal...
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Article
Arthroskopisch gestützte Behandlung der aseptischen Hüftkopfnekrose
Funktionserhalt des Hüftgelenks durch eine Behandlung der aseptischen Hüftkopfnekrose beim Erwachsenen oder zumindest Vermeidung einer Progression des Krankheitsbilds.
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Article
PS2 - 12. Effects of T2D and fasting glucose/insulin associated loci on insulin secretion stimulated by glucose, GLP-1 or arginine as measured by hyperglycaemic clamps
Currently more than 60 genetic loci associated with type 2 diabetes, fasting glucose and/or fasting insulin have been identified by Genome Wide Association Studies (GWAS).
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Article
Erratum to: Body iron stores and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study
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Article
Open AccessBody iron stores and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study
The aim of this study was to prospectively examine the association between body iron stores and risk of type 2 diabetes.
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Article
Exercise-induced albuminuria is associated with perivascular renal sinus fat in individuals at increased risk of type 2 diabetes
Microalbuminuria represents an established surrogate marker of early diabetic nephropathy and glomerular microangiopathy. Increasing evidence is emerging of a role of perivascular adipose tissue (PVAT) as an i...
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Article
Body adiposity index, body fat content and incidence of type 2 diabetes
The aim of this study was to compare estimates of body fat content, i.e. body adiposity index (BAI), BMI and waist and hip circumferences, with respect to their ability to predict the percentage of body fat (P...
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Article
Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and reward-related human brain regions
Impaired insulin sensitivity is a major factor leading to type 2 diabetes. Animal studies suggest that the brain is involved in the regulation of insulin sensitivity. We investigated whether insulin action in ...
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Article
Visceral obesity modulates the impact of apolipoprotein C3 gene variants on liver fat content
It has not been solved whether subjects carrying the minor alleles of the −455T>C or −482C>T single nucleotide polymorphisms (SNPs) in the apolipoprotein-C3-gene (APOC3) have an increased risk for develo** fatt...
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Article
High cerebral insulin sensitivity is associated with loss of body fat during lifestyle intervention
Loss of weight and body fat are major targets in lifestyle interventions to prevent diabetes. In the brain, insulin modulates eating behaviour and weight control, resulting in a negative energy balance. This s...
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Article
Acute, short-term hyperinsulinemia increases olfactory threshold in healthy subjects
Smell plays an important role in feeding behavior. We therefore tested whether insulin as a postprandial signal is involved in the regulation of olfactory function.
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Article
Association of changes in body mass index during earlier adulthood and later adulthood with circulating obesity biomarker concentrations in middle-aged men and women
The objective of our study was to investigate whether changes in BMI during earlier adulthood are more strongly associated with levels of circulating obesity biomarkers in middle age than are BMI changes durin...
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Article
A polymorphism in the gene encoding AdipoR1 affects olfactory recognition
Polymorphisms in the gene encoding adiponectin receptor 1 (AdipoR1) are associated with insulin resistance, fatty liver, increased risk for type 2 diabetes and cardiovascular disease. AdipoR1 is expressed in t...
