203 Result(s)

Article

Neurobehavioral, neurotransmitter and redox modifications in Nauphoeta cinerea under mixed heavy metal (silver and mercury) exposure

Heavy metals are encountered in nature, and are used in several human endeavors, including in dental fillings. It is well known that the safety of metals depends on their chemical form, as well as the dose and...

Olawande C. Olagoke, Opeyemi B. Ogunsuyi, Famutimi E. Mayokun… in BMC Research Notes (2024)

Article

Genetic evidence for causal association between migraine and dementia: a mendelian randomization study

There is an association between migraine and dementia, however, their causal relationship remains unclear. This study employed bidirectional two-sample Mendelian randomization (MR) to investigate the potential...

Qiuyi Chen, Chengcheng Zhang, Shiyang Wu, Yiwei He, Yuhan Liu… in BMC Medical Genomics (2024)

Article

Microglial EPOR Contribute to Sevoflurane-induced Developmental Fine Motor Deficits Through Synaptic Pruning in Mice

Clinical researches including the Mayo Anesthesia Safety in Kids (MASK) study have found that children undergoing multiple anesthesia may have a higher risk of fine motor control difficulties. However, the und...

Danyi He, **aotong Shi, Lirong Liang, Youyi Zhao, Sanxing Ma… in Neuroscience Bulletin (2024)

Article

The immunotoxin targeting PRLR increases tamoxifen sensitivity and enhances the efficacy of chemotherapy in breast cancer

Though tamoxifen achieves success in treating estrogen receptor α (ERα)-positive breast cancer, the followed development of tamoxifen resistance is a common challenge in clinic. Signals downstream of prolactin...

Jiawei Zhang, Junjun Liu, Yali Yue, Lei Wang… in Journal of Experimental & Clinical Cancer … (2024)

Article

Development and validation of an inflammatory biomarkers model to predict gastric cancer prognosis: a multi-center cohort study in China

Inflammatory factors have increasingly become a more cost-effective prognostic indicator for gastric cancer (GC). The goal of this study was to develop a prognostic score system for gastric cancer patients bas...

Shaobo Zhang, Hongxia Xu, Wei Li, Jiuwei Cui, Qingchuan Zhao, Zengqing Guo… in BMC Cancer (2024)

Article

Compensation or Preservation? Different Roles of Functional Lateralization in Speech Perception of Older Non-musicians and Musicians

Musical training can counteract age-related decline in speech perception in noisy environments. However, it remains unclear whether older non-musicians and musicians rely on functional compensation or function...

**nhu **, Lei Zhang, Guowei Wu, **uyi Wang, Yi Du in Neuroscience Bulletin (2024)

Article

Bayesian genome-wide TWAS with reference transcriptomic data of brain and blood tissues identified 141 risk genes for Alzheimer’s disease dementia

Transcriptome-wide association study (TWAS) is an influential tool for identifying genes associated with complex diseases whose genetic effects are likely mediated through transcriptome. TWAS utilizes referenc...

Shuyi Guo, **g**g Yang in Alzheimer's Research & Therapy (2024)

Article

Pathological Changes of Small Vessel Disease in Intracerebral Hemorrhage: a Systematic Review and Meta-analysis

In intracerebral hemorrhage (ICH) with pathology-proven etiology, we performed a systematic review and meta-analysis to elucidate the association between cerebral amyloid angiopathy (CAA) and arteriolosclerosi...

Mangmang Xu, Yuyi Zhu, **ndi Song, Xuelian Zhong… in Translational Stroke Research (2024)

Article

CCR5-overexpressing mesenchymal stem cells protect against experimental autoimmune uveitis: insights from single-cell transcriptome analysis

Autoimmune uveitis is a leading cause of severe vision loss, and animal models provide unique opportunities for studying its pathogenesis and therapeutic strategies. Here we employ scRNA-seq, RNA-seq and vario...

Fa Yuan, Rong Zhang, Jiani Li, Qiannan Lei, Shuyi Wang… in Journal of Neuroinflammation (2024)

Article

AMPK activation eliminates senescent cells in diabetic wound by inducing NCOA4 mediated ferritinophagy

Diabetic wounds are one of the long-term complications of diabetes, with a disordered microenvironment, diabetic wounds can easily develop into chronic non-healing wounds, which can impose a significant burden...

Mengqian Liu, Xuerong Wei, Zijun Zheng, Erlian **e, Qiuyi Yu… in Molecular Medicine (2024)

Article

Correction to: Connexin 43 Promotes Neurogenesis via Regulating Aquaporin-4 after Cerebral Ischemia

Heling Chu, **g Dong, Yu** Tang, Chuyi Huang, Qihao Guo in Neurotoxicity Research (2024)

Article

A novel immunogenic cell death-related classification indicates the immune landscape and predicts clinical outcome and treatment response in acute myeloid leukemia

Immunogenic cell death (ICD) is closely related to anti-tumor therapy and regulates the tumor microenvironment (TME). This study aims to explore the molecular characteristics of ICD in acute myeloid leukemia (...

Fangmin Zhong, Shuyang He, Ni Guo, Luyi Shi, Linlin Zhang… in Cancer Cell International (2024)

Article

Outcome in patients with HIV-associated Hodgkin lymphoma treated with chemotherapy using Doxorubicin, Bleomycin, Vinblastine, and Dacarbazine in the combination antiretroviral therapy (cART) era: results of a multicenter study from China

Little is known about the outcome for HIV-associated Hodgkin lymphoma (HIV-HL) as this is less common than HIV-negative lymphoma. Therefore, we performed a multi-center study to analyze the clinical characteri...

Lirong **ao, Chaoyu Wang, Sai Ma, Yifan Wang, Li** Guan… in Infectious Agents and Cancer (2024)

Article

Full-spectral genome analysis of natural killer/T cell lymphoma highlights impacts of genome instability in driving its progression

Natural killer/T cell lymphoma (NKTCL) is a clinically and genetically heterogeneous disease with poor prognosis. Genome sequencing and mutation characterization provides a powerful approach for patient strati...

Zegeng Chen, He Huang, Huangming Hong, Huageng Huang, Huawei Weng, Le Yu… in Genome Medicine (2024)

Article

Enhanced predictive validity of integrative models for refractory hyperthyroidism considering baseline and early therapy characteristics: a prospective cohort study

A subset of Graves’ disease (GD) patients develops refractory hyperthyroidism, posing challenges in treatment decisions. The predictive value of baseline characteristics and early therapy indicators in identif...

**npan Wang, Tiantian Li, Yue Li, Qiuyi Wang, Yun Cai… in Journal of Translational Medicine (2024)

Article

An in-silico analysis of OGT gene association with diabetes mellitus

O-GlcNAcylation is a nutrient-sensing post-translational modification process. This cycling process involves two primary proteins: the O-linked N-acetylglucosamine transferase (OGT) catalysing the addition, and t...

Abigail O. Ayodele, Brenda Udosen, Olugbenga O. Oluwagbemi… in BMC Research Notes (2024)

Article

Characterization of the biological and transcriptomic landscapes of bone marrow-derived mesenchymal stem cells in patients with multiple myeloma

Mesenchymal stem/stromal cells (MSCs) have been acknowledged as the most important stromal cells in the bone marrow (BM) microenvironment for physiologic hematopoiesis and the concomitant hematologic malignanc...

Yu Lu, Chaohui Zheng, Wenxia Zhang, Xuan Liu, Ziwei Zhou… in Cancer Cell International (2024)

Article

Identification of novel protein biomarkers from the blood and urine for the early diagnosis of bladder cancer via proximity extension analysis

Bladder cancer (BC) is a very common urinary tract malignancy that has a high incidence and lethality. In this study, we identified BC biomarkers and described a new noninvasive detection method using serum an...

Tong Kong, Yang Qu, Taowa Zhao, Zitong Niu, … in Journal of Translational Medicine (2024)

Article

LncRNA WFDC21P interacts with SEC63 to promote gastric cancer malignant behaviors by regulating calcium homeostasis signaling pathway

Gastric cancer is currently estimated to be the fifth leading common cancer in the world, and responsible for about one million new cases and an estimated 769,000 cancer-related deaths each year. WFDC21P is lo...

**yao Dong, Yongqiang Lv, Debin Meng, Ruyi Shi, Feng Li… in Cancer Cell International (2024)

Article

Malaria infection among adults residing in a highly endemic region from the Democratic Republic of the Congo

Adults infected with Plasmodium spp. in endemic areas need to be re-evaluated in light of global malaria elimination goals. They potentially undermine malaria interventions but remain an overlooked aspect of publ...

Nadine Kalenda Kayiba, Yuko Nitahara, Evariste Tshibangu-Kabamba… in Malaria Journal (2024)