143 Result(s)

Article

Matrix metalloproteinase 9 expression and glioblastoma survival prediction using machine learning on digital pathological images

This study aimed to apply pathomics to predict Matrix metalloproteinase 9 (MMP9) expression in glioblastoma (GBM) and investigate the underlying molecular mechanisms associated with pathomics. Here, we include...

Zijun Wu, Yuan Yang, Maojuan Chen, Yunfei Zha in Scientific Reports (2024)

Article

Multi-cohort study on cytokine and chemokine profiles in the progression of COVID-19

Various substances in the blood plasma serve as prognostic indicators of the progression of COVID-19. Consequently, multi-omics studies, such as proteomic and metabolomics, are ongoing to identify accurate bio...

Chaolin Huang, Xujuan Hu, Delong Wang, Rui Gong, Qiongya Wang… in Scientific Reports (2024)

Article

Analysis of the potential regulatory mechanisms of female and latent genital tuberculosis affecting ovarian reserve function using untargeted metabolomics

Female and latent genital tuberculosis (FGTB and LGTB) in young women may lead to infertility by damaging ovarian reserve function, but the regulatory mechanisms remain unclear. In this study, we investigated ...

Zhimin Wang, Xueyan Zhang, Bai Dai, Debang Li, **ujuan Chen in Scientific Reports (2024)

Article

Cysteine protease inhibitor 1 promotes metastasis by mediating an oxidative phosphorylation/MEK/ERK axis in esophageal squamous carcinoma cancer

Cysteine protease inhibitor 1 (CST1) is a cystatin superfamily protein that inhibits cysteine protease activity and is reported to be involved in the development of many malignancies. Mitochondrial oxidative p...

Liangming Zhang, **ongfeng Chen, Jianwei Wang, Meihong Chen… in Scientific Reports (2024)

Article

Moiré effect enables versatile design of topological defects in nematic liquid crystals

Recent advances in surface-patterning techniques of liquid crystals have enabled the precise creation of topological defects, which promise a variety of emergent applications. However, the manipulation and app...

**nyu Wang, **ghua Jiang, Juan Chen, Zhawure Asilehan… in Nature Communications (2024)

Article

Cellular hierarchy insights reveal leukemic stem-like cells and early death risk in acute promyelocytic leukemia

Acute promyelocytic leukemia (APL) represents a paradigm for targeted differentiation therapy, with a minority of patients experiencing treatment failure and even early death. We here report a comprehensive si...

Wen **, Yuting Dai, Li Chen, Honghu Zhu, Fangyi Dong… in Nature Communications (2024)

Article

Neutrophil activation and clonal CAR-T re-expansion underpinning cytokine release syndrome during ciltacabtagene autoleucel therapy in multiple myeloma

Cytokine release syndrome (CRS) is the most common complication of chimeric antigen receptor redirected T cells (CAR-T) therapy. CAR-T toxicity management has been greatly improved, but CRS remains a prime saf...

Shuangshuang Yang, Jie Xu, Yuting Dai, Shiwei **, Yan Sun… in Nature Communications (2024)

Article

A global land cover training dataset from 1984 to 2020

State-of-the-art cloud computing platforms such as Google Earth Engine (GEE) enable regional-to-global land cover and land cover change map** with machine learning algorithms. However, collection of high-qua...

Radost Stanimirova, Katelyn Tarrio, Konrad Turlej, Kristina McAvoy… in Scientific Data (2023)

Article

Delta radiomics analysis for prediction of intermediary- and high-risk factors for patients with locally advanced cervical cancer receiving neoadjuvant therapy

This study aimed to assess the feasibility of using magnetic resonance imaging (MRI)-based Delta radiomics characteristics extrapolated from the Ax LAVA + C series to identify intermediary- and high-risk facto...

Rong-Rong Wu, Yi-Min Zhou, **ng-Yun **e, **-Yang Chen, Ke-Run Quan… in Scientific Reports (2023)

Article

FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes

Cold stimulation dynamically remodels mitochondria in brown adipose tissue (BAT) to facilitate non-shivering thermogenesis in mammals, but what regulates mitochondrial plasticity is poorly understood. Comparin...

Jiamin Qiu, Feng Yue, Peipei Zhu, **gjuan Chen, Fan Xu… in Nature Communications (2023)

Article

Myoglobin-loaded gadolinium nanotexaphyrins for oxygen synergy and imaging-guided radiosensitization therapy

Gadolinium (Gd³⁺)-coordinated texaphyrin (Gd-Tex) is a promising radiosensitizer that entered clinical trials, but temporarily fails largely due to insufficient radiosensitization efficacy. Little attention has b...

**aotu Ma, **aolong Liang, Meinan Yao, Yu Gao, Qi Luo, **aoda Li… in Nature Communications (2023)

Article

Experimental study on the axial tensile properties of polypropylene fiber reinforced concrete

In order to study the axial tensile properties of polypropylene fiber reinforced concrete, an axial tensile test device for concrete is developed in this paper. The device is composed of three parts: rigid fra...

Xutao Zhang, Ruijie Yin, Yunjuan Chen, Chao Lou in Scientific Reports (2023)

Article

Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants

Coronaviruses have been the causative agent of three epidemics and pandemics in the past two decades, including the ongoing COVID-19 pandemic. A broadly-neutralizing coronavirus therapeutic is desirable not on...

Scott A. Hollingsworth, Cameron L. Noland, Karin Vroom, Anasuya Saha… in Scientific Reports (2023)

Article

CD36 mediates SARS-CoV-2-envelope-protein-induced platelet activation and thrombosis

Aberrant coagulation and thrombosis are associated with severe COVID-19 post-SARS-CoV-2 infection, yet the underlying mechanism remains obscure. Here we show that serum levels of SARS-CoV-2 envelope (E) protei...

Zihan Tang, Yanyan Xu, Yun Tan, Hui Shi, Peipei **, Yunqi Li… in Nature Communications (2023)

Article

Nomogram for prognosis of elderly patients with cervical cancer who receive combined radiotherapy

This retrospective study identified prognostic factors to help guide the clinical treatment of elderly patients (≥ 65 years) with cervical cancer who had undergone radiotherapy. A personalized model to predict...

Wenjuan Chen, **aoyi **a, **ngyun **e, Yuting Wei, Rongrong Wu… in Scientific Reports (2023)

Article

Cardiorespiratory dose comparison among six radiotherapy regimens for patients with left-sided breast cancer

There is uncertainty regarding the benefits and drawbacks of various radiation protocols for the treatment of left-sided breast cancer. To address this issue, we conducted a Bayesian network analysis. First, w...

Yongkai Lu, Yanfang Ma, Di Yang, Yi Li, Wei Yuan, Fengwen Tang… in Scientific Reports (2023)

Article

Publisher Correction: Complementary Alu sequences mediate enhancer–promoter selectivity

Liang Liang, Changchang Cao, Lei Ji, Zhaokui Cai, Di Wang, Rong Ye, Juan Chen… in Nature (2023)

Article

Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity

Mitochondrial apoptosis is strictly controlled by BCL-2 family proteins through a subtle network of protein interactions. The tumor suppressor protein p53 triggers transcription-independent apoptosis through d...

Hudie Wei, Haolan Wang, Genxin Wang, Lingzhi Qu, Longying Jiang… in Nature Communications (2023)

Article

Identification of cuproptosis-related lncRNA for predicting prognosis and immunotherapeutic response in cervical cancer

Patients diagnosed with advanced cervical cancer (CC) have poor prognosis after primary treatment, and there is a lack of biomarkers for predicting patients with an increased risk of recurrence of CC. Cupropto...

**aoyu Kong, Yuanpeng **ong, Mei Xue, Jie He, Qinsheng Lu… in Scientific Reports (2023)

Article

Impact of COVID-19 prevention and control on tuberculosis and scarlet fever in China’s Guizhou

China has implemented a series of long-term measures to control the spread of COVID-19, however, the effects of these measures on other chronic and acute respiratory infectious diseases remain unclear. Tubercu...

Jian Zhou, Hui-Juan Chen, Ting-Jia Lu, Pu Chen, Yan Zhuang… in Scientific Reports (2023)