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  1. Article

    Open Access

    Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants

    Coronaviruses have been the causative agent of three epidemics and pandemics in the past two decades, including the ongoing COVID-19 pandemic. A broadly-neutralizing coronavirus therapeutic is desirable not on...

    Scott A. Hollingsworth, Cameron L. Noland, Karin Vroom, Anasuya Saha… in Scientific Reports (2023)

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  2. Article

    Open Access

    An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance

    The Hippo pathway is a key growth control pathway that is conserved across species. The downstream effectors of the Hippo pathway, YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-bin...

    Thijs J. Hagenbeek, Jason R. Zbieg, Marc Hafner, Rana Mroue… in Nature Cancer (2023)

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  3. Article

    Open Access

    Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel

    Unlike classical voltage-gated sodium (NaV) channels, NaX has been characterized as a voltage-insensitive, tetrodotoxin-resistant, sodium (Na+)-activated channel involved in regulating Na+ homeostasis. However, N...

    Cameron L. Noland, Han Chow Chua, Marc Kschonsak… in Nature Communications (2022)

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  4. No Access

    Article

    Structural architecture of the human NALCN channelosome

    Depolarizing sodium (Na+) leak currents carried by the NALCN channel regulate the resting membrane potential of many neurons to modulate respiration, circadian rhythm, locomotion and pain sensitivity1–8. NALCN re...

    Marc Kschonsak, Han Chow Chua, Claudia Weidling, Nourdine Chakouri… in Nature (2022)

  5. No Access

    Article

    Structure of the human sodium leak channel NALCN

    Persistently depolarizing sodium (Na+) leak currents enhance electrical excitability1,2. The ion channel responsible for the major background Na+ conductance in neurons is the Na+ leak channel, non-selective (NAL...

    Marc Kschonsak, Han Chow Chua, Cameron L. Noland, Claudia Weidling… in Nature (2020)

  6. No Access

    Article

    Structure of the essential inner membrane lipopolysaccharide–PbgA complex

    Lipopolysaccharide (LPS) resides in the outer membrane of Gram-negative bacteria where it is responsible for barrier function1,2. LPS can cause death as a result of septic shock, and its lipid A core is the targe...

    Thomas Clairfeuille, Kerry R. Buchholz, Qingling Li, Erik Verschueren, Peter Liu… in Nature (2020)

  7. No Access

    Article

    Substrate-specific structural rearrangements of human Dicer

    Human Dicer can process long double-stranded RNA and hairpin precursor RNA to yield short interfering RNAs or microRNAs, respectively. EM and single-particle analyses of Dicer–substrate complexes now provide i...

    David W Taylor, Enbo Ma, Hideki Shigematsu… in Nature Structural & Molecular Biology (2013)