-
Article
Open AccessCausal relationship between bone mineral density and intervertebral disc degeneration: a univariate and multivariable mendelian randomization study
Although previous studies have suggested a possible association between bone mineral density (BMD) and intervertebral disc degeneration (IDD), the causal relationship between them remains unclear. Evidence fro...
-
Article
Sedimentary characteristics and development model of the bedded evaporites in the Paleogene Kumugeliemu formation, Kuqa depression, Northwestern China
In recent years, extensive exploration has contributed to significant advancements in the geological formations of the Kuqa Depression. In particular, the Paleogene Kumugeliemu Formation exhibits the developme...
-
Article
Open AccessIdentification of diagnostic markers for moyamoya disease by combining bulk RNA-sequencing analysis and machine learning
Moyamoya disease (MMD) remains a chronic progressive cerebrovascular disease with unknown etiology. A growing number of reports describe the development of MMD relevant to infection or autoimmune diseases. Ide...
-
Article
Cadmium negatively affects the growth and physiological status and the alleviation effects by exogenous selenium in silage maize (Zea mays L.)
Increasing soil cadmium (Cd) contamination is a serious threat to human food health and safety. In order to reduce Cd uptake and Cd toxicity in silage maize, hydroponic tests were conducted to investigate the ...
-
Article
Open AccessThe value of indocyanine green-FLOW800 in microvasculature for predicting cerebral hyperperfusion syndrome in moyamoya disease patients
Among the notable complications of direct hemodynamic reconstruction for moyamoya disease (MMD) is cerebral hyperperfusion syndrome (CHS). In this study, we evaluated hemodynamic changes in small regional micr...
-
Article
Identification of Myxobolus distalisensis n. sp. (Cnidaria: Myxozoa) infecting yellow catfish Tachysurus fulvidraco (Richardson), with a supplement description of M. voremkhai (Akhmerov, 1960) Landsberg and Lom, 1991
With growing scale of intensive fish cultivation, the risk of parasite infection in commercial fish is increased. Precisely identifying and characterizing the parasites that infect the farmed fish is critical ...
-
Article
ASO Visual Abstract: Sintilimab Plus Modified FOLFIRINOX in Metastatic or Recurrent Pancreatic Cancer: The Randomized Phase II CISPD3 Trial
-
Article
Sintilimab Plus Modified FOLFIRINOX in Metastatic or Recurrent Pancreatic Cancer: The Randomized Phase II CISPD3 Trial
Folinic acid, fluorouracil, irinotecan, and oxaliplatin (FOLFIRINOX) or modified FOLFIRINOX (mFFX) is the first-line standard of care for metastatic pancreatic adenocarcinoma; effective and safe treatment stra...
-
Article
Research advances in identification procedures of endocrine disrupting chemicals
Endocrine disrupting chemicals (EDCs) are increasingly concerned substance endangering human health and environment. However, there is no unified standard for identifying chemicals as EDCs, which is also contr...
-
Article
Open AccessPRMT2 promotes RCC tumorigenesis and metastasis via enhancing WNT5A transcriptional expression
Protein arginine methyltransferase 2 (PRMT2) is involved in several biological processes via histone methylation and transcriptional regulation. Although PRMT2 has been reported to affect breast cancer and gli...
-
Article
Lycorine induces apoptosis of acute myeloid leukemia cells and inhibits triglyceride production via binding and targeting FABP5
Acute myeloid leukemia (AML) is the most common hematopoietic malignancy with abnormal lipid metabolism. However, currently available information on the involvement of the alterations in lipid metabolism in AM...
-
Article
Exosomes from bone marrow-derived mesenchymal stem cells facilitate corneal wound healing via regulating the p44/42 MAPK pathway
This study was aimed at exploring the function of Exosomes isolated from bone marrow-derived mesenchymal stem cells (BMSC-Exos) in corneal wound healing and at revealing the underlying mechanisms involving the...
-
Article
Semisupervised anomaly detection of multivariate time series based on a variational autoencoder
In a large-scale cloud environment, many key performance indicators (KPIs) of entities are monitored in real time. These multivariate time series consist of high-dimensional, high-noise, random and time-depend...
-
Article
Open AccessTargeting ubiquitin-specific protease 8 sensitizes anti-programmed death-ligand 1 immunotherapy of pancreatic cancer
Programmed death-1 (PD-1) and its ligand programmed death-ligand 1 (PD-L1) help tumor cells evade immune surveillance, and are regarded as important targets of anti-tumor immunotherapy. Post-translational modi...
-
Article
Open AccessNormalization of tumor markers and a clear resection margin affect progression-free survival of patients with unresectable pancreatic cancer who have undergone conversion surgery
With the advent of intensive combination regimens, an increasing number of patients with unresectable pancreatic cancer (UPC) have regained the opportunity for surgery. We investigated the clinical benefits an...
-
Chapter and Conference Paper
Asynchronous and Decentralized Multiagent Trajectory Planning in Dense Environments
This paper proposes an online decentralized and asynchronous multiagent trajectory planning algorithm in dense environments. In our algorithm, the optimization problem is transformed into a quadratic programmi...
-
Article
Open AccessInsights into the deriving of rhizosphere microenvironments and its effects on the growth of authentic Angelica sinensis seedlings under continuous monoculture
Continuous monoculture leads to deterioration of soil microenvironment, which can severely threat the quality and efficiency of Angelica sinensis (A. sinensis), especially for seedlings production. However, littl...
-
Article
Open AccessResearch on the effectiveness of a intersection risk warning system based on driving simulation experiment
In order to improve the traffic safety condition of intersections, a real-time traffic conflict risk warning system (RTCRWS) is proposed for uncontrolled intersections. To evaluate the effectiveness of this sy...
-
Article
OSBN: architecture and control mechanism of optical switched satellite backbone network
With the success of commercial spaceflights, space information infrastructure (SII) has received much attention in recent years. Blueprints such as the low earth orbit global communication network and the data...
-
Article
Partially reduced graphene oxide-based electrolyte: synthesis and electrochemical capacitance performance
The increasing demand for higher-energy-density supercapacitors driven by advancements in devices necessitates the development of alternative electrolytes with a higher specific capacity or larger voltage wind...