39 Result(s)
within
Chapter
Qi** Li
Biomedicine
Immunology
Medical Microbiology
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Exotoxins of Staphylococcus aureus
Staphylococcus aureus produces a variety of exotoxins, which are important virulence factors for S. aureus-related diseases. Representatively, staphylococcal enterotoxins induce staphylococcal food-born poisoning...
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Animal Models of Tuberculosis
Tuberculosis (TB) is an important zoonotic disease caused by infection with Mycobacterium tuberculosis (Mtb) complex and has a significant impact on public health. Animal models are suitable tools to mimic the cl...
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Galectins in Host Defense Against Microbial Infections
Galectins are differentially expressed in a variety of cell types, including immune cells, and characterized by the affinity for β-galactoside–containing glycans. There are fifteen galectin members in mammals....
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Opportunities and Challenges in Activity-Based Protein Profiling of Mycobacteria
Mycobacteria, from saprophytic to pathogenic species, encounter diverse environments that demand metabolic versatility and rapid adaptation from these bacteria for their survival. The human pathogen Mycobacterium...
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Correction to: Echinodermata: The Complex Immune System in Echinoderms
Correction to: Chapter 13 in: E. L. Cooper (ed.), Advances in Comparative Immunology, https://doi.org/10.1007/978-3-319-76768-0_13
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Echinodermata: The Complex Immune System in Echinoderms
The Echinodermata are an ancient phylum of benthic marine invertebrates with a dispersal-stage planktonic larva. These animals have innate immune systems characterized initially by clearance of foreign particl...
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Immunopathogenesis of Chlamydial Infections
Chlamydial infections lead to a number of clinically relevant diseases and induce significant morbidity in human populations. It is generally understood that certain components of the host immune response to i...
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Adipose Tissue-Resident Regulatory T Cells
Tissue-resident immune cells play critical roles in regulating tissue function and homeostasis. Obesity-associated visceral adipose tissue inflammation is attributed to the accumulation of M1 macrophages which...
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A Practical Guide to Recombineering in Photorhabdus and Xenorhabdus
Fluent genetic manipulation of prokaryote genomes is still limited to only a few commonly used hosts. Ideally the advanced technologies available for cloning into recombinant Escherichia coli should also be appli...
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Regulation of Metabolism Across Different Subsets of T Cells in Cancer
T cells play a critical role to defend against tumor and maintain immune homeostasis. The diverse functions of T cells require precise regulation of metabolic pathways. Recent studies reveal that metabolic cha...
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Macrophages and RhoA Pathway in Transplanted Organs
RhoA is a small GTPase that, via its downstream effectors, regulates a variety of cell functions such as cytokinesis, cell migration, vesicular trafficking, and phagocytosis. As such the RhoA pathway is also p...
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Transcriptional Regulation of T Cell Metabolism Reprograming
T cell activation, differentiation, and function are tightly regulated by a complex network of transcription factors, epigenetic modifications, and signaling pathways of both TCR and cytokines. Over the past d...
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Immune Cell Metabolism in Tumor Microenvironment
Tumor microenvironment (TME) is composed of tumor cells, immune cells, cytokines, extracellular matrix, etc. The immune system and the metabolisms of glucose, lipids, amino acids, and nucleotides are integrate...
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Introduction: A Review of Lasso Peptide Research
Lasso peptides form a unique family of bacterial ribosomally synthesized peptides that are post-translationally modified by dedicated enzymes, which confer them a specific interlocked topology called the ‘lass...
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Lasso Peptide Bioengineering and Bioprospecting
Lasso peptides are ribosomally synthesized, post-translationally modified peptides produced by bacteria. They share an interlocked topology, consisting of a macrolactam ring at the N-terminus and a C-terminal ...
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Biological Activities of Lasso Peptides and Structure–Activity Relationships
Lasso peptides are peptides of bacterial origin that share a specific interlocked topology formed by a macrolactam ring threaded by a peptidic tail that is trapped and locked inside. Bulky side chains of amino...
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Regulation of Nitrogenase by Reversible Mono-ADP-Ribosylation
Posttranslational modification of proteins plays a key role in the regulation of a plethora of metabolic functions. Protein modification by mono-ADP-ribosylation was first described as a mechanism of action of...
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Mutational Profile of HPV-Positive HNSCC
This chapter summarizes the mutational profile of head and neck squamous cell cancer (HNSCC) associated with infection of the human papillomavirus (HPV). Focusing on next-generation sequencing studies, the dif...
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From the Producer Microorganisms to the Lasso Scaffold
Lasso peptides are members of the ribosomally synthesized and post-translationally modified peptides produced by bacteria. Currently known lasso peptides are produced in the phyla of Proteobacteria or Actinoba...
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Biosynthesis, Regulation and Export of Lasso Peptides
Lasso peptides are ribosomally synthesized and posttranslationally modified peptides (RiPPs) produced by bacteria. As such, they are synthesized as linear precursor peptides, which are further subjected to pos...
