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Gadolinium retention effect on macrophages — a potential cause of MRI contrast agent Dotarem toxicity
Gadolinium is a component of the MRI contrast agent Dotarem. Although Dotarem is the least toxic among MRI contrasts used, gadolinium present in Dotarem accumulates for many years in various organs and tissues...
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Article
Virus interactions with the actin cytoskeleton—what we know and do not know about SARS-CoV-2
The actin cytoskeleton and actin-dependent molecular and cellular events are responsible for the organization of eukaryotic cells and their functions. Viruses, including severe acute respiratory syndrome coro...
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Book
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Chapter
Histone Modifications in Mouse Pronuclei and Consequences for Embryo Development
Epigenetic marks, such as DNA methylation and posttranslational modifications of core histones, are the key regulators of gene expression. In the mouse, many of these marks are erased during gamete formation a...
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Article
Children were less frequently infected with SARS-CoV-2 than adults during 2020 COVID-19 pandemic in Warsaw, Poland
Clinical data suggest that during the current COVID-19 pandemic, children are less prone than adults to SARS-CoV-2 infection. Our purpose was to determine the frequency of SARS-CoV-2 in children vs. adults dur...
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Article
Macrophages in diabetes mellitus (DM) and COVID-19: do they trigger DM?
Diabetes mellitus (DM) augments the risk of hospitalization and mortality resulting from viral, bacterial, or fungal pathogen infection. This has been also true for the past SARS and MERS, and current SARS-CoV...
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Chapter
The Macrophages and Intestinal Symbiosis
The human intestinal tract is inhabited by trillions of microorganisms and houses the largest pool of macrophages in the human body. Being a part of the innate immune system, the macrophages, the professional ...
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Article
Open AccessTranscriptome profiling reveals male- and female-specific gene expression pattern and novel gene candidates for the control of sex determination and gonad development in Xenopus laevis
Xenopus laevis is an amphibian (frog) species widely used in developmental biology and genetics. To unravel the molecular machinery regulating sex differentiation of Xenopus gonads, we analyzed for the first time...
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Chapter
RhoA Pathway and Actin Regulation of the Golgi/Centriole Complex
In vertebrate cells, the Golgi apparatus is located in close proximity to the centriole. The architecture of the Golgi/centriole complex depends on a multitude of factors, including the actin filament cytoske...
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Article
Open AccessEffects of Hexachlorophene, a Chemical Accumulating in Adipose Tissue, on Mouse and Human Mesenchymal Stem Cells
The hexachlorophene (HCP) is a highly lipophilic chlorinated bisphenol present in hygienic and dermatological products. The HCP accumulates preferentially in adipose tissue that is a privileged source of mesen...
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Reference Work Entry In depth
Structural mRNAs
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Reference Work Entry In depth
Cyclin B
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Protocol
In Vitro Culture of Mouse Oocytes for Meiotic Maturation
In vitro maturation of mouse oocytes, as well as of many other mammalian species, is used commonly in experimental embryology. This model system gives the possibility to easily obtain maturing oocytes at desir...
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Book
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Chapter
Macrophages and RhoA Pathway in Transplanted Organs
RhoA is a small GTPase that, via its downstream effectors, regulates a variety of cell functions such as cytokinesis, cell migration, vesicular trafficking, and phagocytosis. As such the RhoA pathway is also p...
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Chapter
Role of Cdc6 During Oogenesis and Early Embryo Development in Mouse and Xenopus laevis
Cdc6 is an important player in cell cycle regulation. It is involved in the regulation of both S-phase and M-phase. Its role during oogenesis is crucial for repression of the S-phase between the first and the ...
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Chapter
Elusive Role of TCTP Protein and mRNA in Cell Cycle and Cytoskeleton Regulation
Translationally Controlled Tumor-associated Protein (TCTP) is a small, 23 kDa multifunctional and ubiquitous protein localized both in the cytoplasm and in the nucleus of eukaryotic cells. It is evolutionarily...
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Chapter
Exogenous Molecule and Organelle Delivery in Oogenesis
Recent discoveries on the delivery of small- and large-size molecules and organelles to the oocytes/eggs from external sources, such as surrounding somatic cells, body fluids, and sperm, change our understandi...
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Chapter
Asymmetric Divisions in Oogenesis
In the majority of animals, the oocyte/egg is structurally, molecularly, and functionally asymmetric. Such asymmetry is a prerequisite for a flawless fertilization and faithful segregation of maternal determin...
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Article
Dissonant response of M0/M2 and M1 bone-marrow-derived macrophages to RhoA pathway interference
Macrophages have a multitude of functions in innate and adaptive immune response and organ and tissue homeostasis. Many experimental studies are performed on bone-marrow-derived macrophages differentiated in v...
