38 Result(s)

Article

Gadolinium retention effect on macrophages — a potential cause of MRI contrast agent Dotarem toxicity

Gadolinium is a component of the MRI contrast agent Dotarem. Although Dotarem is the least toxic among MRI contrasts used, gadolinium present in Dotarem accumulates for many years in various organs and tissues...

Marta Halasa, Ahmed Uosef, Henry V. Ubelaker, Arijita Subuddhi… in Cell and Tissue Research (2024)

Chapter

Germline and Somatic Cell Syncytia in Insects

Syncytia are common in the animal and plant kingdoms both under normal and pathological conditions. They form through cell fusion or division of a founder cell without cytokinesis. A particular type of syncyti...

Malgorzata Kloc, Wacław Tworzydło… in Syncytia: Origin, Structure, and Functions (2024)

Chapter

Histone Modifications in Mouse Pronuclei and Consequences for Embryo Development

Epigenetic marks, such as DNA methylation and posttranslational modifications of core histones, are the key regulators of gene expression. In the mouse, many of these marks are erased during gamete formation a...

Ewa Borsuk, Julia Michalkiewicz… in Nuclear, Chromosomal, and Genomic Architec… (2022)

Article

Siponimod (Mayzent) Downregulates RhoA and Cell Surface Expression of the S1P1 and CX3CR1 Receptors in Mouse RAW 264.7 Macrophages

The Siponimod (Mayzent) is a newly developed drug, similar to Fingolimod (FTY720) but with fewer side effects, approved by the Food and Drug Administration for the treatment of multiple sclerosis (MS). The the...

Ahmed Uosef, Nicole Vaughn, **ufeng Chu… in Archivum Immunologiae et Therapiae Experim… (2020)

Chapter

The Macrophages and Intestinal Symbiosis

The human intestinal tract is inhabited by trillions of microorganisms and houses the largest pool of macrophages in the human body. Being a part of the innate immune system, the macrophages, the professional ...

Malgorzata Kloc, Ahmed Uosef… in Symbiosis: Cellular, Molecular, Medical an… (2020)

Article

Macrophage phenotype bioengineered by magnetic, genetic, or pharmacologic interference

In all eukaryotes, the cell shape depends on the actin filament cytoskeleton, which is regulated by the small GTPase RhoA. It is well known that the cell shape determines cell function and behavior. Inversely,...

Jarek Wosik, Martha Suarez-Villagran, John H. Miller Jr… in Immunologic Research (2019)

Chapter

The Rove Beetle Creophilus maxillosus as a Model System to Study Asymmetric Division, Oocyte Specification, and the Germ-Somatic Cell Signaling

Creophilus maxillosus (Staphylinidae, Coleoptera, Polyphaga) has a meroistic-telotrophic ovary composed of tropharium, which contains trophocytes (nurse cells) and vitellarium, which contains growing oocytes. Th...

Malgorzata Kloc in Evo-Devo: Non-model Species in Cell and Developmental Biology (2019)

Chapter

RhoA Pathway and Actin Regulation of the Golgi/Centriole Complex

In vertebrate cells, the Golgi apparatus is located in close proximity to the centriole. The architecture of the Golgi/centriole complex depends on a multitude of factors, including the actin filament cytoske...

Malgorzata Kloc, Ahmed Uosef, Jarek Wosik… in The Golgi Apparatus and Centriole (2019)

Reference Work Entry In depth

Structural mRNAs

Malgorzata Kloc, Jacek Z. Kubiak in Encyclopedia of Signaling Molecules (2018)

Reference Work Entry In depth

Cyclin B

Jacek Z. Kubiak, Mikolaj Cup, Jakub Janiec… in Encyclopedia of Signaling Molecules (2018)

Chapter

Macrophages and RhoA Pathway in Transplanted Organs

RhoA is a small GTPase that, via its downstream effectors, regulates a variety of cell functions such as cytokinesis, cell migration, vesicular trafficking, and phagocytosis. As such the RhoA pathway is also p...

Yianzhu Liu, Jacek Z. Kubiak, **an C. Li, Rafik M. Ghobrial, Malgorzata Kloc in Macrophages (2017)