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Biosynthesis, Regulation and Export of Lasso Peptides

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Lasso Peptides

Part of the book series: SpringerBriefs in Microbiology ((BRIEFSMICROBIOL))

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Abstract

Lasso peptides are ribosomally synthesized and posttranslationally modified peptides (RiPPs) produced by bacteria. As such, they are synthesized as linear precursor peptides, which are further subjected to posttranslational modifications and transformed into the mature form. These 15–24-residue peptides share a unique interlocked topology formed by an N-terminal macrolactam ring where the C-terminal tail is threaded and irreversibly trapped. However, access to such a constrained and entropically disfavoured topology is not possible by chemical means, while bacteria evolve specific enzymes that are capable of transforming a linear precursor into the lasso topology. This chapter describes current knowledge of the maturation mechanism, which includes the characteristics of the maturation enzymes and accessory enzymes, the role of the leader peptides and a proposed reaction model. Moreover, this chapter reviews known mechanisms of the regulation and export of lasso peptides.

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  1. Laboratory of Communication Molecules and Adaptation of Microorganisms, Muséum National d’Histoire Naturelle CNRS, Paris, France

    Yanyan Li, Séverine Zirah & Sylvie Rebuffat

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  1. Yanyan Li
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Correspondence to Yanyan Li .

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© 2015 Yanyan Li, Séverine Zirah and Sylvie Rebuffat

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Li, Y., Zirah, S., Rebuffat, S. (2015). Biosynthesis, Regulation and Export of Lasso Peptides. In: Lasso Peptides. SpringerBriefs in Microbiology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1010-6_4

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