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Article
Open AccessThe significance of microscopic mass spectrometry with high resolution in the visualisation of drug distribution
The visualisation and quantitative analysis of the native drug distribution in a pre-clinical or clinical setting are desirable for evaluating drug effects and optimising drug design. Here, using matrix-assist...
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Article
Open AccessImaging mass spectrometry for the precise design of antibody-drug conjugates
Antibody-drug conjugates (ADCs) are a class of immunotherapeutic agents that enable the delivery of cytotoxic drugs to target malignant cells. Because various cancers and tumour vascular endothelia strongly ex...
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Article
Open AccessMolecular imaging using an anti-human tissue factor monoclonal antibody in an orthotopic glioma xenograft model
Nuclear medicine examinations for imaging gliomas have been introduced into clinical practice to evaluate the grade of malignancy and determine sampling locations for biopsies. However, these modalities have s...
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Article
Open Accessp70S6K/Akt dual inhibitor DIACC3010 is efficacious in preclinical models of gastric cancer alone and in combination with trastuzumab
The PI3K-Akt-mTOR (PAM) pathway is implicated in tumor progression in many tumor types, including metastatic gastric cancer (GC). The initial promise of PAM inhibitors has been unrealized in the clinic, presum...