216 Result(s)
within
English
Science, Humanities and Social Sciences, multidisciplinary
Yi-**u Zhao
Article
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Article
Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
Ataxia-telangiectasia (A-T) and Nijmegen breakage syndrome (NBS) are recessive genetic disorders with susceptibility to cancer and similar cellular phenotypes1. The protein product of the gene responsible for A-T...
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Open AccessUnique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing
Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage and jaundice. In more severe cases, massive pul...
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Rational design of a structural and functional nitric oxide reductase
Considerable progress has been made in the design of proteins that mimic native proteins both structurally and functionally. Metalloproteins present more of a challenge owing to their complexity, but Yi Lu and...
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The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
The inflammasomes are multiprotein complexes involved in innate immunity, and induce an immune response to pathogenic microbes by activating the caspase 1 protease. Two groups now report that the intracellular...
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Open AccessThe role of aromatic L-amino acid decarboxylase in bacillamide C biosynthesis by Bacillus atrophaeus C89
For biosynthesis of bacillamide C by Bacillus atrophaeus C89 associated with South China sea sponge Dysidea avara, it is hypothesized that decarboxylation from L-tryptophan to tryptamine could be performed before...
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Open AccessSiO2 nanoparticles change colour preference and cause Parkinson's-like behaviour in zebrafish
With advances in the development of various disciplines, there is a need to decipher bio-behavioural mechanisms via interdisciplinary means. Here, we present an interdisciplinary study of the role of silica na...
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Open AccessDisorganized vascular structures in sporadic venous malformations: a possible correlation with balancing effect between Tie2 and TGF-β
Venous malformations (VMs) are among the most common slow-flow vascular malformations characterized by irregular venous channels, luminal thrombi and phleboliths. To systematically manifest the disorganized va...
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Open AccessSulfurization induced surface constitution and its correlation to the performance of solution-processed Cu2ZnSn(S,Se)4 solar cells
To obtain high photovoltaic performances for the emerging copper zinc tin sulfide/selenide (CZTSSe) thin film solar cells, much effort has deservedly been placed on CZTSSe phase purification and CZTSSe grain s...
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Open AccessBacteria can mobilize nematode-trap** fungi to kill nematodes
In their natural habitat, bacteria are consumed by bacterivorous nematodes; however, they are not simply passive preys. Here we report a defensive mechanism used by certain bacteria to mobilize nematode-trappi...
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Open AccessSynergistic strengthening of polyelectrolyte complex membranes by functionalized carbon nanotubes and metal ions
Hydrophilic polymers have garnered much attention due to their critical roles in various applications such as molecular separation membranes, bio-interfaces and surface engineering. However, a long-standing pr...
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Open AccessNeuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells
Epstein–Barr virus (EBV) is implicated as an aetiological factor in B lymphomas and nasopharyngeal carcinoma. The mechanisms of cell-free EBV infection of nasopharyngeal epithelial cells remain elusive. EBV gl...
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Open AccessRoom temperature synthesis of cobalt-manganese-nickel oxalates micropolyhedrons for high-performance flexible electrochemical energy storage device
Cobalt-manganese-nickel oxalates micropolyhedrons were successfully fabricated by a room temperature chemical co-precipitation method. Interestingly, the Co0.5Mn0.4Ni0.1C2O4*nH2O micropolyhedrons and graphene nan...
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Open AccessRapid preparation of rare ginsenosides by acid transformation and their structure-activity relationships against cancer cells
The anticancer activities of ginsenosides are widely reported. The structure-activity relationship of ginsenosides against cancer is not well elucidated because of the unavailability of these compounds. In thi...
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Open AccessA Nomogram for Predicting the Benefit of Adjuvant Cytokine-Induced Killer Cell Immunotherapy in Patients with Hepatocellular Carcinoma
The benefits of adjuvant cytokine-induced killer (CIK) cell immunotherapy for hepatocellular carcinoma (HCC) remain mixed among patients. Here, we constructed a prognostic nomogram to enable individualized pre...
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Enhanced electrochemical stimuli multilayers based on a ferrocene-containing polymer
Based on the noncovalent functionalization of ferrocene-grafted polyethylenimine (PEI-Fc) and carbon nanotubes (CNTs), CNT bundles are exfoliated by PEI-Fc solution and thus form stable compounds PEI-Fc@CNTs, ...
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Open AccessThe Clinical Features and Bacteriological Characterizations of Bone and Joint Tuberculosis in China
Bone and Joint tuberculosis (BJTB) constitutes about 10% of total extra-pulmonary TB cases. Since the BJTB is a paucibacillary condition, there has been no systematic study on the bacterial characterization, e...
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Lanosterol reverses protein aggregation in cataracts
Exploring the genetic basis of congenital cataracts in two families identifies a molecule, lanosterol, which prevents intracellular protein aggregation of various cataract-causing mutant crystallins, and which...
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Open AccessGenome-scale long noncoding RNA expression pattern in squamous cell lung cancer
In this study, we aimed to explore the long noncoding RNA expression pattern in squamous cell lung cancer (SQCC) on a genome-wide scale. Total RNAs were extracted from 16 lung SQCC patients’ normal and matched...
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Open AccessGenetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone
The genome sequences of 175 Ebola virus from five districts in Sierra Leone, collected during September–November 2014, show that the rate of virus evolution seems to be similar to that observed during previous...
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Open AccessPharmacokinetics of a multicomponent herbal preparation in healthy Chinese and African volunteers
K-601 is an herbal formulation for influenza consisting of Lonicera japonica, Isatis indigotica, Rheum palmatum, Phellodendron chinense and Scutellaria baicalensis. In this work, we characterized the chemical con...
