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  1. Article

    Open Access

    The immunological function of familial Mediterranean fever disease protein Pyrin

    Pyrin, encoded by MEFV gene, is conserved in humans and mice. Mutations in the MEFV gene are associated with the human autoinflammatory disease familial Mediterranean fever (FMF). Pyrin can interact with the infl...

    JieLing Yang, Hao Xu, Feng Shao in Science China Life Sciences (2014)

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  2. Article

    Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

    The Pyrin inflammasome detects the presence of a pathogen not through recognition of a microbial molecule but by the activity of a bacterial toxin that modifies host Rho activity.

    Hao Xu, Jieling Yang, Wenqing Gao, Lin Li, Peng Li, Li Zhang, Yi-Nan Gong… in Nature (2014)

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    Article

    The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

    The inflammasomes are multiprotein complexes involved in innate immunity, and induce an immune response to pathogenic microbes by activating the caspase 1 protease. Two groups now report that the intracellular...

    Yue Zhao, Jieling Yang, Jian** Shi, Yi-Nan Gong, Qiuhe Lu, Hao Xu, Li** Liu… in Nature (2011)

  4. Article

    Chemical probing reveals insights into the signaling mechanism of inflammasome activation

    Caspase-1-mediated IL-1β production is generally controlled by two pathways. Toll-like receptors (TLRs) recognize pathogen-derived products and induce NF-κB-dependent pro-IL-1β transcription; NOD-like receptor...

    Yi-Nan Gong, **aoming Wang, Jiayi Wang, Zhenxiao Yang, Shan Li… in Cell Research (2010)

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