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Article
MLKL ubiquitylation: more than a makeover
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Article
Initiation of Acupoint Molecular Mechanisms for Manual Acupuncture Analgesia—Nuclear Factor κB Signaling Pathway
To identify the prominent molecular signaling in acupoints and explore their roles in initiating the analgesia effect of manual acupuncture (MA).
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Article
Bloodletting Puncture at Hand Twelve **g-Well Points Relieves Brain Edema after Severe Traumatic Brain Injury in Rats via Inhibiting MAPK Signaling Pathway
To investigate whether blood-brain barrier (BBB) served a key role in the edema-relief effect of bloodletting puncture at hand twelve **g-well points (HTWP) in traumatic brain injury (TBI) and the potential m...
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Article
Exploration of Stratified Evidence Scoring Method of Acupuncture Clinical Practice Guidelines
Due to its own internal laws of development, Chinese medicine (CM) seems more inclined to empirical medicine in a relatively long historical period. It is considered to be lacking objective and unified clinica...
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Article
Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome
The Pyrin inflammasome detects the presence of a pathogen not through recognition of a microbial molecule but by the activity of a bacterial toxin that modifies host Rho activity.
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Article
Sensing bacterial infections by NAIP receptors in NLRC4 inflammasome activation
The inflammasome is an emerging new pathway in innate immune defense against microbial infection or endogenous danger signals. The inflammasome stimulates activation of inflammatory caspases, mainly caspase-1....
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Article
Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation
A conserved protein from enteropathogenic Escherichia coli, NleE, inhibits innate immune defence against infection by disrupting the NF-κB signalling pathway through methylation of ubiquitin-chain sensing protein...
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Article
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
The inflammasomes are multiprotein complexes involved in innate immunity, and induce an immune response to pathogenic microbes by activating the caspase 1 protease. Two groups now report that the intracellular...
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Article
Chemical probing reveals insights into the signaling mechanism of inflammasome activation
Caspase-1-mediated IL-1β production is generally controlled by two pathways. Toll-like receptors (TLRs) recognize pathogen-derived products and induce NF-κB-dependent pro-IL-1β transcription; NOD-like receptor...
