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Article
Vitellogenin accumulation leads to reproductive senescence by impairing lysosomal function
The maintenance of proteostasis is essential for cellular and organism healthspan. How proteostasis collapse influences reproductive span remains largely unclear. In Caenorhabditis elegans, excess accumulation of...
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Article
Open AccessThe metabolite alpha-ketobutyrate extends lifespan by promoting peroxisomal function in C. elegans
Metabolism is intimately linked to aging. There is a growing number of studies showing that endogenous metabolites may delay aging and improve healthspan. Through the analysis of existing transcriptome data, w...
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Article
Association Between Homocysteine and Type 2 Diabetes Mellitus: a Systematic Review and Meta-analysis
Several studies have been performed to assess the relationship between hyperhomocysteinemia and type 2 diabetes mellitus (T2DM). However, inconsistent results have been obtained. Therefore, we performed this m...
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Article
Open AccessAdiponectin receptor PAQR-2 signaling senses low temperature to promote C. elegans longevity by regulating autophagy
Temperature is a key factor for determining the lifespan of both poikilotherms and homeotherms. It is believed that animals live longer at lower body temperatures. However, the precise mechanism remains largel...
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Article
The NADPH oxidase AoNoxA in Arthrobotrys oligospora functions as an initial factor in the infection of Caenorhabditis elegans
Reactive oxygen species (ROS) produced by NADPH oxidases can serve as signaling molecules to regulate a variety of physiological processes in multi-cellular organisms. In the nematophagous fungus Arthrobotrys oli...
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Article
Open AccessThe cAMP-PKA pathway-mediated fat mobilization is required for cold tolerance in C. elegans
Low temperature has a great impact on animal life. Homoiotherms such as mammals increase their energy expenditure to produce heat by activating the cAMP-protein kinase A (PKA)-hormone-sensitive lipase (HSL) pa...
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Article
Open AccessAntioxidant response is a protective mechanism against nutrient deprivation in C. elegans
Animals often experience periods of nutrient deprivation; however, the molecular mechanisms by which animals survive starvation remain largely unknown. In the nematode Caenorhabditis elegans, the nuclear receptor...
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Article
Open AccessAmeliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats
Non-alcoholic fatty liver disease (NAFLD) is a common liver disease, which has no standard treatment available. Panax notoginseng saponines (PNS) have recently been reported to protect liver against hepatocyte...
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Article
GPH1 is involved in glycerol accumulation in the three-dimensional networks of the nematode-trap** fungus Arthrobotrys oligospora
Turgor is very important for the invasive growth of fungal pathogens. Glycerol, a highly osmotic solvent, is considered to play an important role in turgor generation. The nematophagous fungus Arthrobotrys oligos...
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Article
Open AccessNuclear receptor nhr-48 is required for pathogenicity of the second stage (J2) of the plant parasite Meloidogyne incognita
Nuclear receptors (NRs) are a diverse class of transcription factors, which are involved in regulating a large number of physiological events in metazoans. However, the function of NRs is poorly understood in ...
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Article
Open AccessOral microbial community ty** of caries and pigment in primary dentition
Black extrinsic discoloration in primary dentition is a common clinical and aesthetic problem that can co-occur with dental caries, the most common oral diseases in childhood. Although the role of bacteria in ...
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Article
Open AccessSystematic analyses reveal uniqueness and origin of the CFEM domain in fungi
CFEM domain commonly occurs in fungal extracellular membrane proteins. To provide insights for understanding putative functions of CFEM, we investigate the evolutionary dynamics of CFEM domains by systematic c...
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Article
Open AccessBacteria can mobilize nematode-trap** fungi to kill nematodes
In their natural habitat, bacteria are consumed by bacterivorous nematodes; however, they are not simply passive preys. Here we report a defensive mechanism used by certain bacteria to mobilize nematode-trappi...
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Article
Homocysteine enhances cell proliferation in hepatic myofibroblastic stellate cells
Homocysteine is an intermediate in sulfur amino acid metabolism, which takes place mainly in the liver. Recent studies have shown that hyperhomocysteinemia in patients and murine models develop hepatic fibrosi...
