21 Result(s)

Article

Correction to: Safety assessment, whole genome sequence, and metabolome analysis of Streptococcus thermophilus CICC 20372 for bone cement fermentation

Rongshan Li, Yangfan Hu, Yang Xu, **long Zhou, Yunfang Li… in Archives of Microbiology (2024)

Article

IKK1 aggravates ischemia–reperfusion kidney injury by promoting the differentiation of effector T cells

Ischemia–reperfusion injury (IRI) is one of the major causes of acute kidney injury (AKI), and experimental work has revealed detailed insight into the inflammatory response in the kidney. T cells and NFκB pat...

Ning Song, Yang Xu, Hans-Joachim Paust, Ulf Panzer… in Cellular and Molecular Life Sciences (2023)

Article

Loss of RBMS1 promotes anti-tumor immunity through enabling PD-L1 checkpoint blockade in triple-negative breast cancer

Immunotherapy has been widely utilized in multiple tumors, however, its efficacy in the treatment of triple-negative breast cancers (TNBC) is still being challenged. Meanwhile, functions and mechanisms of RNA ...

**rui Zhang, Ge Zhang, Wen**g Zhang, Lu Bai, Luning Wang… in Cell Death & Differentiation (2022)

Article

The role of S-nitrosylation of PFKM in regulation of glycolysis in ovarian cancer cells

One of the malignant transformation hallmarks is metabolism reprogramming, which plays a critical role in the biosynthetic needs of unchecked proliferation, abrogating cell death programs, and immunologic esca...

Wenwen Gao, Mengqiu Huang, ** Chen, Jian** Chen, Zhiwei Zou… in Cell Death & Disease (2021)

Article

MiR-127-3p targeting CISD1 regulates autophagy in hypoxic–ischemic cortex

Neonatal hypoxic–ischemic (HI) injury derived from asphyxia during perinatal period, is a serious complication of neonatal asphyxia and the main cause of neonatal acute death and chronic neurological injury. A...

Zi-Bin Zhang, Liu-Lin **ong, Lu-Lu Xue, Yan-** Deng, Ruo-Lan Du… in Cell Death & Disease (2021)

Article

The heterocyclic compound Tempol inhibits the growth of cancer cells by interfering with glutamine metabolism

Tempol (4-hydroxy-2,2,6,6-Tetramethylpiperidine-1-oxyl, TPL), a nitroxide compound, inhibits proliferation and increases the vulnerability of cancer cells to apoptosis induced by cytotoxic agents. However, the...

Shuangyan Ye, Pengfei Xu, Mengqiu Huang, ** Chen, Sisi Zeng… in Cell Death & Disease (2020)

Article

CAS9 is a genome mutator by directly disrupting DNA-PK dependent DNA repair pathway

With its high efficiency for site-specific genome editing and easy manipulation, the clustered regularly interspaced short palindromic repeats (CRISPR)/ CRISPR associated protein 9 (CAS9) system has become the...

Shuxiang Xu, **chul Kim, Qingshuang Tang, Qu Chen, **gfeng Liu, Yang Xu… in Protein & Cell (2020)

Article

Functions of p53 in pluripotent stem cells

Pluripotent stem cells (PSCs) are capable of unlimited self-renewal in culture and differentiation into all functional cell types in the body, and thus hold great promise for regenerative medicine. To achieve ...

Xuemei Fu, Shouhai Wu, Bo Li, Yang Xu, **gfeng Liu in Protein & Cell (2020)

Article

Core pluripotency factors promote glycolysis of human embryonic stem cells by activating GLUT1 enhancer

Human embryonic stem cells (hESCs) depend on glycolysis for energy and substrates for biosynthesis. To understand the mechanisms governing the metabolism of hESCs, we investigated the transcriptional regulatio...

Lili Yu, Kai-yuan Ji, Jian Zhang, Yanxia Xu, Yue Ying, Taoyi Mai… in Protein & Cell (2019)

Article

A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1

The E3 ligase HERC4 is overexpressed in human breast cancer and its expression levels correlated with the prognosis of breast cancer patients. However, the roles of HERC4 in mammary tumorigenesis remain unclea...

Youqin Xu, Kaiyuan Ji, Meng Wu, Bingtao Hao, Kai-tai Yao, Yang Xu in Protein & Cell (2019)

Article

Grb2 binds to PTEN and regulates its nuclear translocation to maintain the genomic stability in DNA damage response

Growth factor receptor bound protein 2 (Grb2) is an adaptor protein critical for signal transduction and endocytosis, but its role in DNA damage response (DDR) remains unknown. Here, we report that either knoc...

Bolin Hou, Shanshan Xu, Yang Xu, Quan Gao, Caining Zhang, Ling Liu… in Cell Death & Disease (2019)

Article

Long non-coding RNA linc00665 promotes lung adenocarcinoma progression and functions as ceRNA to regulate AKR1B10-ERK signaling by sponging miR-98

Long non-coding RNAs (lncRNAs) are frequently dysregulated in multiple malignancies, demonstrating their potential oncogenic or tumor-suppressive roles in tumorigenesis. Herein, we reported the identification ...

Zhuangzhuang Cong, Yifei Diao, Yang Xu, **aokun Li, Zhisheng Jiang… in Cell Death & Disease (2019)

Article

Estrogen receptors in granulosa cells govern meiotic resumption of pre-ovulatory oocytes in mammals

In mammals, oocytes are arrested at the diplotene stage of meiosis I until the pre-ovulatory luteinizing hormone (LH) surge triggers meiotic resumption through the signals in follicular granulosa cells. In thi...

Wei Liu, Qiliang **n, **ao Wang, Sheng Wang, Huarong Wang… in Cell Death & Disease (2017)

Article

Obacunone activates the Nrf2-dependent antioxidant responses

Shengmei Xu, Weimin Chen, Qingfeng **e, Yang Xu in Protein & Cell (2016)

Article

An Integrated Strategy for Implementation of Dried Blood Spots in Clinical Development Programs

Dried blood spot (DBS) sample collection has gained increased interest across the pharmaceutical industry as a potential alternative to plasma for pharmacokinetic (PK) evaluations. However, regulatory guidelin...

Prajakti A. Kothare, Kevin P. Bateman, Marissa Dockendorf, Julie Stone… in The AAPS Journal (2016)

Article

Functional analysis of the acetylation of human p53 in DNA damage responses

As a critical tumor suppressor, p53 is inactivated in human cancer cells by somatic gene mutation or disruption of pathways required for its activation. Therefore, it is critical to elucidate the mechanism und...

Sun-Ku Chung, Shengyun Zhu, Yang Xu, Xuemei Fu in Protein & Cell (2014)

Article

Homologous recombination in human embryonic stem cells using CRISPR/Cas9 nickase and a long DNA donor template

Zhili Rong, Shengyun Zhu, Yang Xu, Xuemei Fu in Protein & Cell (2014)

Article

Genetic approach to track neural cell fate decisions using human embryonic stem cells

With their capability to undergo unlimited self-renewal and to differentiate into all cell types in the body, human embryonic stem cells (hESCs) hold great promise in human cell therapy. However, there are lim...

Xuemei Fu, Zhili Rong, Shengyun Zhu, **aocheng Wang, Yang Xu… in Protein & Cell (2014)

Article

RETRACTED ARTICLE: MAVS protects cells from apoptosis by negatively regulating VDAC1

Yang Xu, Hui Zhong, Wei Shi in Molecular and Cellular Biochemistry (2013)

Article

The genomic stability of induced pluripotent stem cells

With their capability to undergo unlimited self-renewal and to differentiate into all cell types in the body, induced pluripotent stem cells (iPSCs), reprogrammed from somatic cells of human patients with defi...

Zhao Chen, Tongbiao Zhao, Yang Xu in Protein & Cell (2012)