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Article
Open AccessExosomal HMGA2 protein from EBV-positive NPC cells destroys vascular endothelial barriers and induces endothelial-to-mesenchymal transition to promote metastasis
Increased vascular permeability facilitates metastasis. Cancer-secreted exosomes are emerging mediators of cancer-host crosstalk. Epstein-Barr virus (EBV), identified as the first human tumor-associated virus,...
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Article
Open AccessCore pluripotency factors promote glycolysis of human embryonic stem cells by activating GLUT1 enhancer
Human embryonic stem cells (hESCs) depend on glycolysis for energy and substrates for biosynthesis. To understand the mechanisms governing the metabolism of hESCs, we investigated the transcriptional regulatio...
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Article
Open AccessA miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1
The E3 ligase HERC4 is overexpressed in human breast cancer and its expression levels correlated with the prognosis of breast cancer patients. However, the roles of HERC4 in mammary tumorigenesis remain unclea...
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Article
Open AccessThe important role of the receptor for activated C kinase 1 (RACK1) in nasopharyngeal carcinoma progression
The receptor for activated C kinase 1 (RACK1) is involved in various cancers, but its roles in nasopharyngeal carcinoma (NPC) have not yet been fully elucidated.
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Article
Cancer stem cell characteristics, ALDH1 expression in the invasive front of nasopharyngeal carcinoma
The invasive tumor front underlies the biological aggressiveness and epithelial–mesenchymal transition (EMT) in various human malignances. However, the molecular and biological characteristics of invasive tumo...
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Article
Open AccessNuclear β-catenin accumulation is associated with increased expression of Nanog protein and predicts poor prognosis of non-small cell lung cancer
Although the prognostic roles of β-catenin expression in non-small cell lung cancer (NSCLC) have been reported in several immunohistochemical (IHC) studies, the results were not consistent because some studies...
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Article
Open AccessLentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of a human nasopharyngeal carcinoma cell line against cisplatin
High resistance to drug is taken as a characteristic of human tumors, which is usually mediated by multidrug resistance-associated genes. ABCC2, an ATP-binding cassette multidrug resistance transporter, is fou...
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Article
Open AccessGenCLiP: a software program for clustering gene lists by literature profiling and constructing gene co-occurrence networks related to custom keywords
Biomedical researchers often want to explore pathogenesis and pathways regulated by abnormally expressed genes, such as those identified by microarray analyses. Literature mining is an important way to assist ...
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Article
Identification of label-retaining cells in nasopharyngeal epithelia and nasopharyngeal carcinoma tissues
Adult stem cells can be identified by label-retaining cell (LRC) approach based on their ability to retain nucleoside analog, such as bromodeoxyuridine (BrdU). We hypothesized that mouse nasopharynx contains a...
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Article
Open AccessChromosomal imbalances in nasopharyngeal carcinoma: a meta-analysis of comparative genomic hybridization results
Nasopharyngeal carcinoma (NPC) is a highly prevalent disease in Southeast Asia and its prevalence is clearly affected by genetic background. Various theories have been suggested for its high incidence in this ...
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Article
Possible reasons for TP53 accumulation in nasopharyngeal carcinoma using atlas human cancer cDNA expression array
Objective: To compare gene expression profiles of nasopharyngeal carcinoma (NPC) tissue with that of control tissue by cDNA Array and to discuss possible reasons of TP53 accumulation in NPC tissue. Methods: (1...
