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Article
Open AccessGrb2 interacts with necrosome components and is involved in rasfonin-induced necroptosis
The underlying mechanism by which growth factor receptor-bound protein 2 (Grb2) regulates necroptosis remains unexplored. In the present study, we found that rasfonin, a fungal natural product and an activator...
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Article
Open AccessSQSTM1/p62 loss reverses the inhibitory effect of sunitinib on autophagy independent of AMPK signaling
Sunitinib (ST), a multitargeted receptor tyrosine kinase inhibitor, has been demonstrated to be effective for the treatment of renal carcinoma. It has been reported that ST is involved in the mediation of auto...
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Article
Open AccessGrb2 binds to PTEN and regulates its nuclear translocation to maintain the genomic stability in DNA damage response
Growth factor receptor bound protein 2 (Grb2) is an adaptor protein critical for signal transduction and endocytosis, but its role in DNA damage response (DDR) remains unknown. Here, we report that either knoc...
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Article
Open AccessSunitinib induces genomic instability of renal carcinoma cells through affecting the interaction of LC3-II and PARP-1
Deficiency of autophagy has been linked to increase in nuclear instability, but the role of autophagy in regulating the formation and elimination of micronuclei, a diagnostic marker for genomic instability, is...
