51 Result(s)
within
Article
Tetsuya Sakurai
English
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Article
Moreau-Yoshida variational transport: a general framework for solving regularized distributional optimization problems
We address a general optimization problem involving the minimization of a composite objective functional defined over a class of probability distributions. The objective function consists of two components: on...
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Open AccessDC-SHAP Method for Consistent Explainability in Privacy-Preserving Distributed Machine Learning
Ensuring the transparency of machine learning models is vital for their ethical application in various industries. There has been a concurrent trend of distributed machine learning designed to limit access to ...
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Mirror variational transport: a particle-based algorithm for distributional optimization on constrained domains
We consider the optimization problem of minimizing an objective functional, which admits a variational form and is defined over probability distributions on a constrained domain, which poses challenges to both th...
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Open AccessData collaboration analysis in predicting diabetes from a small amount of health checkup data
Recent studies showed that machine learning models such as gradient-boosting decision tree (GBDT) can predict diabetes with high accuracy from big data. In this study, we asked whether highly accurate predicti...
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Fully sequencing the cassava full-length cDNA library reveals unannotated transcript structures and alternative splicing events in regions with a high density of single nucleotide variations, insertions–deletions, and heterozygous sequences
The primary transcript structure provides critical insights into protein diversity, transcriptional modification, and functions. Cassava transcript structures are highly diverse because of alternative splicing...
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Open Accessm5U-SVM: identification of RNA 5-methyluridine modification sites based on multi-view features of physicochemical features and distributed representation
RNA 5-methyluridine (m5U) modifications are obtained by methylation at the C5 position of uridine catalyzed by pyrimidine methylation transferase, which is related to the development of human diseases. Accurate i...
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Open AccessDeep generative model for drug design from protein target sequence
Drug discovery for a protein target is a laborious and costly process. Deep learning (DL) methods have been applied to drug discovery and successfully generated novel molecular structures, and they can substan...
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Distortion-free PCA on sample space for highly variable gene detection from single-cell RNA-seq data
Single-cell RNA-seq (scRNA-seq) allows the analysis of gene expression in each cell, which enables the detection of highly variable genes (HVG) that contribute to cell-to-cell variation within a homogeneous ce...
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Open AccessExtracellular vesicles derived from Wharton’s Jelly mesenchymal stem cells inhibit the tumor environment via the miR-125b/HIF1α signaling pathway
Triple negative breast cancer (TNBC) is associated with worse outcomes and results in high mortality; therefore, great efforts are required to find effective treatment. In the present study, we suggested a nov...
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Open AccessDecentralized Learning with Virtual Patients for Medical Diagnosis of Diabetes
Machine learning, applied to medical data, can uncover new knowledge and support medical practices. However, analyzing medical data by machine learning methods presents a trade-off between accuracy and privacy...
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Open AccessA genome resource for green millet Setaria viridis enables discovery of agronomically valuable loci
Wild and weedy relatives of domesticated crops harbor genetic variants that can advance agricultural biotechnology. Here we provide a genome resource for the wild plant green millet (Setaria viridis), a model spe...
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Open AccessLocalization-specific distributions of protein pI in human proteome are governed by local pH and membrane charge
Whole-proteome distributions of protein isoelectric point (pI) values in different organisms are bi- or trimodal with some variations. It was suggested that the observed multimodality of the proteome-wide pI d...
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International workshop on eigenvalue problems: algorithms; software and applications, in petascale computing (EPASA2018)
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Benefits from using mixed precision computations in the ELPA-AEO and ESSEX-II eigensolver projects
We first briefly report on the status and recent achievements of the ELPA-AEO (Eigen value Solvers for Petaflop Applications—Algorithmic Extensions and Optimizations) and ESSEX II (Equip** Sparse Solvers for...
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Open AccessTranscriptional alterations during proliferation and lignification in Phyllostachys nigra cells
Highly-lignified culms of bamboo show distinctive anatomical and mechanical properties compared with the culms of other grass species. A cell culture system for Phyllostachys nigra has enabled investigating the a...
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Clinical relevance of active straight leg raising, standing up, and walking after total knee arthroplasty in a cross-sectional study
Active straight leg raising (ASLR) is used to assess restoration of the quadriceps muscle immediately after total knee arthroplasty (TKA). This study aimed to (1) compare the times required to accomplish ASLR,...
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Parallel Implementation of the Nonlinear Semi-NMF Based Alternating Optimization Method for Deep Neural Networks
For computing weights of deep neural networks (DNNs), the backpropagation (BP) method has been widely used as a de-facto standard algorithm. Since the BP method is based on a stochastic gradient descent method...
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Comparison of long-term clinical outcomes after bilateral mobile-bearing total knee arthroplasties using PCL-retaining and PCL-substituting implants in the same patients
Whether the posterior cruciate ligament (PCL) should be retained or substituted in total knee arthroplasty (TKA) remains an issue of concern. The purpose of this study was to perform within-patient comparisons...
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Quadriceps strength impairment in the mid- to long-term follow-up period after total knee arthroplasty
Quadriceps strength impairment after total knee arthroplasty (TKA) continues to be a concern. However, most studies of quadriceps strength have short-term follow-up periods. Whether quadriceps strength impairm...
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Anteroposterior translation and range of motion after total knee arthroplasty using posterior cruciate ligament-retaining versus posterior cruciate ligament-substituting prostheses
It is still controversial whether anteroposterior (AP) translation magnitude after total knee arthroplasty (TKA) affects clinical outcomes, particularly range of motion (ROM). This study examined the followin...
