-
Article
Open AccessProtocol of a Prospective Observational Study on Lifestyle and Quality of Life in Adults with Type 1 Diabetes in Japan
Recent studies have shown that the quality of life (QOL) of people living with type 1 diabetes (T1D) is poor and must be improved. However, the living situation and QOL of adults living with T1D in Japan have ...
-
Article
Open AccessExtracting the latent needs of dementia patients and caregivers from transcribed interviews in japanese: an initial assessment of the availability of morpheme selection as input data with Z-scores in machine learning
Given the increasing number of dementia patients worldwide, a new method was developed for machine learning models to identify the ‘latent needs’ of patients and caregivers to facilitate patient/public involve...
-
Article
Patient factors impacting localization of popliteal artery before total knee arthroplasty
Intraoperative injury to the popliteal artery (PA) should be avoided during total knee arthroplasty (TKA). This study was performed to clarify the preoperative localization of the PA and the patient factors th...
-
Article
Positive effect of total knee arthroplasty on progression of arteriosclerosis evaluated by cardio-ankle vascular index
Physical function is expected to improve with an increase in physical activity owing to improvement in knee joint pain after total knee arthroplasty (TKA). This study was performed to evaluate the impact of TK...
-
Article
Open AccessPreoperative characteristics and intraoperative factors do not correlate with accomplishments of active straight-leg raising, standing up, and walking after primary total knee arthroplasty
The correlations between patient characteristics and early postoperative functional performances after total knee arthroplasty have not been adequately studied. The purpose of this study was to clarify the eff...
-
Article
Open AccessStudy factors associated with the incompletion of clinical trials that include pediatric patients: a retrospective analysis of the European Clinical Trials Database and a lesson from the European region
Incomplete clinical trials for pediatric drug development result in a lack of adequate scientific evidence for providing appropriate medication to pediatric populations; this is especially true for Japan. Thus...
-
Article
Real World Survey of Patient Engagement Status in Clinical Research: The First Input from Japan
The updated international draft guidelines, the “General Considerations for Clinical Studies, ICH E8 (R1)”, state that patient engagement ensures that all perspectives are captured in the research process; how...
-
Article
Medical nutrition therapy and dietary counseling for patients with diabetes-energy, carbohydrates, protein intake and dietary counseling
-
Article
Mobile-bearing total knee arthroplasty implants combined with surface cementation produced satisfactory clinical and radiographic outcomes at the 5-year follow-up
Very little is known about the use of combined surface cementation (only tibial tray) and mobile-bearing tibial components in total knee arthroplasty (TKA). This study was investigated whether the index combin...
-
Article
Mediolateral coronal laxity does not correlate with knee range of motion after total knee arthroplasty
It remains controversial whether coronal laxity after total knee arthroplasty (TKA) is a critical factor in determining clinical outcomes such as knee range of motion (ROM). The purpose of this study was to ev...
-
Article
Insall–Salvati ratio stabilizes one year after mobile-bearing total knee arthroplasty and does not correlate with mid-to-long-term clinical outcomes
It has not been established whether changes in the length of the patellar tendon (LPT) after total knee arthroplasty (TKA) affect clinical outcomes. Therefore, this prospective cohort study aimed to evaluate c...
-
Article
Open AccessThe Effect of Linagliptin versus Metformin Treatment-Related Quality of Life in Patients with Type 2 Diabetes Mellitus
There have been no studies directly comparing the effect of dipeptidyl peptidase-4 inhibitors with that of metformin on treatment-related quality of life (QOL) when used as first-line therapy in patients with ...
-
Article
Tibial component coverage and rotational alignment accuracy after mobile-bearing total knee arthroplasty
Tibial component coverage (TCC) and tibial rotational angle (TRA) have been studied simultaneously in simulations, but not in clinical studies after total knee arthroplasty (TKA). The purposes of this study we...
-
Article
Clinical relevance of active straight leg raising, standing up, and walking after total knee arthroplasty in a cross-sectional study
Active straight leg raising (ASLR) is used to assess restoration of the quadriceps muscle immediately after total knee arthroplasty (TKA). This study aimed to (1) compare the times required to accomplish ASLR,...
-
Article
Open AccessStudy Protocol for the Initial Choice of DPP-4 Inhibitor in Japanese Patients with Type 2 diabetes Mellitus: Effect of Linagliptin on QOL (INTEL-QOL) Trial
Consideration of treatment-related quality of life (QOL) is important in diabetes management. However, no studies have compared the influence of dipeptidyl peptidase-4 inhibitors versus metformin on treatment-...
-
Article
Comparison of long-term clinical outcomes after bilateral mobile-bearing total knee arthroplasties using PCL-retaining and PCL-substituting implants in the same patients
Whether the posterior cruciate ligament (PCL) should be retained or substituted in total knee arthroplasty (TKA) remains an issue of concern. The purpose of this study was to perform within-patient comparisons...
-
Article
Patellar tendon length during knee flexion of meniscal-bearing and rotating total knee arthroplasty implants
The length of the patellar tendon after total knee arthroplasty (TKA) has most commonly been compared with preoperative measurements. However, there are no reports that discuss changes in the length of the pa...
-
Article
Quadriceps strength impairment in the mid- to long-term follow-up period after total knee arthroplasty
Quadriceps strength impairment after total knee arthroplasty (TKA) continues to be a concern. However, most studies of quadriceps strength have short-term follow-up periods. Whether quadriceps strength impairm...
-
Article
Anteroposterior translation and range of motion after total knee arthroplasty using posterior cruciate ligament-retaining versus posterior cruciate ligament-substituting prostheses
It is still controversial whether anteroposterior (AP) translation magnitude after total knee arthroplasty (TKA) affects clinical outcomes, particularly range of motion (ROM). This study examined the followin...
-
Article
Open AccessProbiotic reduces bacterial translocation in type 2 diabetes mellitus: A randomised controlled study
Gut bacterial translocation to the blood may play an important role in the development of insulin resistance in type 2 diabetes. Here, we performed an interventional randomised control study to investigate whe...
