373 Result(s)

Article

Histone deacetylase 1 and 2 differentially regulate apoptosis by opposing effects on extracellular signal-regulated kinase 1/2

Histone deacetylases (HDACs) are epigenetic regulators that are important for the control of various pathophysiological events. We found that HDAC inhibitors completely abolished transforming growth factor-β1 (TG...

W-W Lei, K-H Zhang, X-C Pan, D-M Wang, Y Hu, Y-N Yang, J-G Song in Cell Death & Disease (2010)

Article

HIV-1 Nef compensates for disorganization of the Immunological Synapse by inducing TGN-associated Lck signaling

**aoyu Pan, Jochen M Rudolph, Libin Abraham, Anja Habermann… in Retrovirology (2011)

Article

Crystal structure analysis of anti-V2 mAb 2158 suggests a conformational epitope involving an N-linked glycan

B Spurrier, R Pan, J Sampson, C Williams, M Gorny, S Zolla-Pazner, X Kong in Retrovirology (2012)

Article

Structural analyses of antigen binding similarities and differences between rabbit and human anti-gp120 V3 mAbs

R Pan, JM Sampson, Y Chen, M Vaine, S Wang, S Lu, X Kong in Retrovirology (2012)

Article

Sequential exposure to specific antibody escape mutations may program neutralization breadth during subtype A HIV-1 infection

MK Murphy, L Yue, R Pan, S Boliar, A Sethi, E Karita, SA Allen, E Cormier… in Retrovirology (2012)

Article

A bivalent recombinant protein inactivates HIV-1 by targeting the gp41 prehairpin fusion intermediate induced by CD4 D1D2 domains

Most currently approved anti-HIV drugs (e.g., reverse transcriptase inhibitors, protease inhibitors and fusion/entry inhibitors) must act inside or on surface of the target cell to inhibit HIV infection, but none...

Lu Lu, Chungen Pan, Yuan Li, Hong Lu, Wu He, Shibo Jiang in Retrovirology (2012)

Article

Cuprous oxide nanoparticles inhibit the growth and metastasis of melanoma by targeting mitochondria

Metal and its oxide nanoparticles show ideal pharmacological activity, especially in anti-tumor therapy. Our previous study demonstrated that cuprous oxide nanoparticles (CONPs) selectively induce apoptosis of...

Y Wang, F Yang, H-X Zhang, X-Y Zi, X-H Pan, F Chen, W-D Luo, J-X Li… in Cell Death & Disease (2013)

Article

The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells

Epidermal growth factor receptor (EGFR), which promotes cell survival and division, is found at abnormally high levels on the surface of many cancer cell types, including many cases of non-small cell lung canc...

M-C Chen, C-H Chen, J-C Wang, A-C Tsai, J-P Liou, S-L Pan, C-M Teng in Cell Death & Disease (2013)

Article

The interferon-induced MxB protein inhibits an early step of HIV-1 infection

Zhenlong Liu, Qinghua Pan, Shilei Ding, ** Qian, Fengwen Xu, **ming Zhou… in Retrovirology (2013)

Article

Functional characterization of HIV-1 Nef proteins with heterologous membrane targeting signals

Miriam M Geist, **aoyu Pan, Oliver T Fackler in Retrovirology (2013)

Article

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

Induction of cell death and inhibition of cell survival are the main principles of cancer therapy. Resistance to chemotherapeutic agents is a major problem in oncology, which limits the effectiveness of antica...

X Sui, R Chen, Z Wang, Z Huang, N Kong, M Zhang, W Han, F Lou… in Cell Death & Disease (2013)

Article

Light-controlled inhibition of malignant glioma by opsin gene transfer

Glioblastomas are aggressive cancers with low survival rates and poor prognosis because of their highly proliferative and invasive capacity. In the current study, we describe a new optogenetic strategy that se...

F Yang, J Tu, J-Q Pan, H-L Luo, Y-H Liu, J Wan, J Zhang, P-F Wei… in Cell Death & Disease (2013)

Article

Heparin-binding EGF-like growth factor and miR-1192 exert opposite effect on Runx2-induced osteogenic differentiation

Osteoblast differentiation is a pivotal event in bone formation. Runt-related transcription factor-2 (Runx2) is an essential factor required for osteoblast differentiation and bone formation. However, the unde...

S Yu, Q Geng, J Ma, F Sun, Y Yu, Q Pan, A Hong in Cell Death & Disease (2013)

Article

Galectin-1 overexpression promotes progression and chemoresistance to cisplatin in epithelial ovarian cancer

This study was performed to investigate the role of galectin-1 (Gal-1) in epithelial ovarian cancer (EOC) progression and chemoresistance. Tissue samples from patients with EOC were used to examine the correla...

P Zhang, P Zhang, B Shi, M Zhou, H Jiang, H Zhang, X Pan, H Gao… in Cell Death & Disease (2014)

Article

A positive feedback loop between EBP2 and c-Myc regulates rDNA transcription, cell proliferation, and tumorigenesis

The oncoprotein c-Myc is a key transcription factor with essential functions in the nucleolus (NO) to regulate ribosomal RNA (rRNA) synthesis, ribosome biogenesis, and cell proliferation. Yet, the mechanism th...

P Liao, W Wang, M Shen, W Pan, K Zhang, R Wang, T Chen, Y Chen… in Cell Death & Disease (2014)

Article

MicroRNA-181a-mediated downregulation of AC9 protein decreases intracellular cAMP level and inhibits ATRA-induced APL cell differentiation

AC9 is one of the adenylate cyclase (AC) isoforms, which catalyze the conversion of ATP to cAMP, an important second messenger. We previously found that the integration of cAMP/PKA pathway with nuclear recepto...

L K Zhuang, G P Xu, X R Pan, Y J Lou, Q P Zou, D **a, W W Yan… in Cell Death & Disease (2014)

Article

Orally active microtubule-targeting agent, MPT0B271, for the treatment of human non-small cell lung cancer, alone and in combination with erlotinib

Microtubule-binding agents, such as taxanes and vinca alkaloids, are used in the treatment of cancer. The limitations of these treatments, such as resistance to therapy and the need for intravenous administrat...

A-C Tsai, C-Y Wang, J-P Liou, H-C Pai, C-J Hsiao, J-Y Chang… in Cell Death & Disease (2014)

Article

The histone methyltransferase ESET is required for the survival of spermatogonial stem/progenitor cells in mice

Self-renewal and differentiation of spermatogonial stem cells (SSCs) are the foundation of spermatogenesis throughout a male’s life. SSC transplantation will be a valuable solution for young male patients to p...

J An, X Zhang, J Qin, Y Wan, Y Hu, T Liu, J Li, W Dong, E Du, C Pan… in Cell Death & Disease (2014)

Article

CT45A1 acts as a new proto-oncogene to trigger tumorigenesis and cancer metastasis

Cancer/testis antigen (CTA)-45 family (CT45) belongs to a new family of genes in phylogenetics and is absent in normal tissues except for testis, but is aberrantly overexpressed in various cancer types. Whethe...

B Shang, A Gao, Y Pan, G Zhang, J Tu, Y Zhou, P Yang, Z Cao, Q Wei… in Cell Death & Disease (2014)

Article

Depletion of intermediate filament protein Nestin, a target of microRNA-940, suppresses tumorigenesis by inducing spontaneous DNA damage accumulation in human nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is a major malignant tumor of the head and neck region in southern China. The understanding of its underlying etiology is essential for the development of novel effective therapi...

J Ma, F Sun, C Li, Y Zhang, W **ao, Z Li, Q Pan, H Zeng, G **ao… in Cell Death & Disease (2014)