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Article
Do NPM1 and FLT3-ITD mutations modify prognosis in patients treated with non-intensive regimens?
FLT3-ITD and NPM1 mutations are key to defining the genetic risk profile of acute myeloid leukemia (AML). We aimed to assess the prognostic features of the FLT3-ITD and NPM1 mutations in old and/or unfit individu...
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Article
Investigating Human-Robot Teams for Learning-Based Semi-autonomous Control in Urban Search and Rescue Environments
Teams of semi-autonomous robots can provide valuable assistance in Urban Search and Rescue (USAR) by efficiently exploring cluttered environments and searching for potential victims. Their advantage over solel...
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Article
Open AccessLoss of Fas apoptosis inhibitory molecule leads to spontaneous obesity and hepatosteatosis
Altered hepatic lipogenesis is associated with metabolic diseases such as obesity and hepatosteatosis. Insulin resistance and compensatory hyperinsulinaemia are key drivers of these metabolic imbalances. Fas a...
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Article
Cytoplasmic translocation, aggregation, and cleavage of TDP-43 by enteroviral proteases modulate viral pathogenesis
We have previously demonstrated that infection by coxsackievirus B3 (CVB3), a positive-stranded RNA enterovirus, results in the accumulation of insoluble ubiquitin–protein aggregates, which resembles the commo...
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Article
Open AccessDepletion of intermediate filament protein Nestin, a target of microRNA-940, suppresses tumorigenesis by inducing spontaneous DNA damage accumulation in human nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is a major malignant tumor of the head and neck region in southern China. The understanding of its underlying etiology is essential for the development of novel effective therapi...
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Article
Open AccessHeparin-binding EGF-like growth factor and miR-1192 exert opposite effect on Runx2-induced osteogenic differentiation
Osteoblast differentiation is a pivotal event in bone formation. Runt-related transcription factor-2 (Runx2) is an essential factor required for osteoblast differentiation and bone formation. However, the unde...
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Channel Modeling
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Article
Open AccessZoledronic acid significantly improves pain scores and quality of life in breast cancer patients with bone metastases: a randomised, crossover study of community vs hospital bisphosphonate administration
Patients with bone metastases from breast cancer often experience substantial skeletal complications – including debilitating bone pain – which negatively affect quality of life. Zoledronic acid (4 mg) has bee...
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Article
The posterior sagittal trans-sphincteric and trans-rectal approaches
Background: The posterior sagittal, transphincteric approach to treat different pelvic problems has been known since the last century. Although some surgeons have embraced it and have enthusiastically advocated ...
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Article
Extracorporeal irradiation — novel use of a blood product irradiator
A CS-137 blood product irradiator (BPI) is used for extracorporeal irradiation of bone grafts. For dose verification purposes two bone phantoms were constructed of plaster of Paris and irradiated in the BPI. T...
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Article
National scientific medical meeting 1995 abstracts
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Article
Unilobar Caroli's disease
We report the case of a 9-year-old girl with asymptomatic unilobar Caroli's disease (CD). This is the youngest reported case and only the sixth to involve exclusively the right lobe. Though it is a rare congen...
