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    Article

    miR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis

    Human cancers often exhibit attenuated microRNA (miRNA) biogenesis and global underexpression of miRNAs; thus, targeting the miRNA biogenesis pathway represents a novel strategy for cancer therapy. Here, we re...

    X Fu, Z Meng, W Liang, Y Tian, X Wang, W Han, G Lou, X Wang, F Lou, Y Yen, H Yu in Oncogene (2014)

  2. Article

    Open Access

    Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

    Induction of cell death and inhibition of cell survival are the main principles of cancer therapy. Resistance to chemotherapeutic agents is a major problem in oncology, which limits the effectiveness of antica...

    X Sui, R Chen, Z Wang, Z Huang, N Kong, M Zhang, W Han, F Lou in Cell Death & Disease (2013)

  3. Article

    Open Access

    Nucleostemin mRNA is expressed in both normal and malignant renal tissues

    Nucleostemin (NS), a p53-binding protein, has been shown essential for stem and cancer cell proliferation and implicated in oncogenesis. To explore potential contributions of NS to the development of clear cel...

    Y Fan, Z Liu, S Zhao, F Lou, S Nilsson, P Ekman, D Xu, X Fang in British Journal of Cancer (2006)

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    Chapter and Conference Paper

    A parallel iterative solver for almost block-diagonal linear systems

    D. Hu, F. Lou, A. Sameh in Applied Parallel Computing Computations in… (1996)