19 Result(s)

Article

Paternal age, de novo mutations and schizophrenia

A E Jaffe, W W Eaton, R E Straub, S Marenco, D R Weinberger in Molecular Psychiatry (2014)

Article

GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia

We conducted data-mining analyses using the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and molecular genetics of schizophrenia genome-wide association study supported by the genetic as...

X Chen, G Lee, B S Maher, A H Fanous, J Chen, Z Zhao, A Guo… in Molecular Psychiatry (2011)

Article

A 5′ promoter region SNP in NRG1 is associated with schizophrenia risk and type III isoform expression

K K Nicodemus, A J Law, A Luna, R Vakkalanka, R E Straub… in Molecular Psychiatry (2009)

Article

Serious obstetric complications interact with hypoxia-regulated/vascular-expression genes to influence schizophrenia risk

The etiology of schizophrenia is thought to include both epistasis and gene-environment interactions. We sought to test whether a set of schizophrenia candidate genes regulated by hypoxia or involved in vascul...

K K Nicodemus, S Marenco, A J Batten, R Vakkalanka, M F Egan… in Molecular Psychiatry (2008)

Article

Imaging epistasis in vivo: COMT and RGS4

J W Buckholtz, M Prust, S Sust, H Y Tan, V S Mattay, R E Straub… in Molecular Psychiatry (2007)

Article

fMRI evidence for functional epistasis between COMT and RGS4

J W Buckholtz, S Sust, H Y Tan, V S Mattay, R E Straub… in Molecular Psychiatry (2007)

Article

Significant correlation in linkage signals from genome-wide scans of schizophrenia and schizotypy

Prior family and adoption studies have suggested a genetic relationship between schizophrenia and schizotypy. However, this has never been verified using linkage methods. We therefore attempted to test for a c...

A H Fanous, M C Neale, C O Gardner, B T Webb, R E Straub… in Molecular Psychiatry (2007)

Article

Allelic variation in GAD1 (GAD₆₇) is associated with schizophrenia and influences cortical function and gene expression

Cortical GABAergic dysfunction has been implicated as a key component of the pathophysiology of schizophrenia and decreased expression of the gamma-aminobutyric acid (GABA) synthetic enzyme glutamic acid decar...

R E Straub, B K Lipska, M F Egan, T E Goldberg, J H Callicott… in Molecular Psychiatry (2007)

Article

Further evidence for association between ErbB4 and schizophrenia and influence on cognitive intermediate phenotypes in healthy controls

K K Nicodemus, A Luna, R Vakkalanka, T Goldberg, M Egan, R E Straub… in Molecular Psychiatry (2006)

Article

GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD₆₇), is associated with childhood-onset schizophrenia and cortical gray matter volume loss

Postmortem brain studies have shown deficits in the cortical γ-aminobutyric acid (GABA) system in schizophrenic individuals. Expression studies have shown a decrease in the major GABA-synthesizing enzyme (glutami...

A M Addington, M Gornick, J Duckworth, A Sporn, N Gogtay, A Bobb… in Molecular Psychiatry (2005)

Article

Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia

Genetic linkage and association have implicated neuregulin-1 (NRG-1) as a schizophrenia susceptibility gene. We measured mRNA expression levels of the three major isoforms of NRG-1 (ie type I, type II, and typ...

R Hashimoto, R E Straub, C S Weickert, T M Hyde, J E Kleinman… in Molecular Psychiatry (2004)

Article

Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes

From our linkage study of Irish families with a high density of schizophrenia, we have previously reported evidence for susceptibility genes in regions 5q21–31, 6p24–21, 8p22–21, and 10p15–p11. In this report,...

R E Straub, C J MacLean, Y Ma, B T Webb, M V Myakishev… in Molecular Psychiatry (2002)

Article

No evidence to support the association of the potassium channel gene hSKCa3 CAG repeat with schizophrenia or bipolar disorder in the Irish population

Anticipation has attracted much interest and has been demonstrated in several neuropsychiatric disorders. For some disorders, this phenomenon has been found to correlate with the repeat number in large and uns...

Z Hawi, L Mynett-Johnson, V Murphy, R E Straub, K S Kendler… in Molecular Psychiatry (1999)

Article

Susceptibility genes for nicotine dependence: a genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study

Cigarette smoking is associated with considerable morbidity, mortality, and public health costs. Genetic factors influence both smoking initiation and nicotine dependence, but none of the genes involved have b...

R E Straub, P F Sullivan, Y Ma, M V Myakishev, C Harris-Kerr… in Molecular Psychiatry (1999)

Article

Examination of new and reported data of the DRD3/MscI polymorphism: no support for the proposed association with schizophrenia

The dopamine D3 (DRD3) receptor gene has been implicated in the aetiology of schizophrenia as a candidate gene since it combines both the dopamine receptor and limbic hypotheses of the disease. Previous associ...

Z Hawi, U McCabe, R E Straub, A O'Neill, K S Kendler, D Walsh… in Molecular Psychiatry (1998)

Article

Support for a possible schizophrenia vulnerability locus in region 5q22–31 in Irish families

In our genome scan for schizophrenia genes in 265 Irish pedigrees, marker D5S818 in 5q22 produced the second best result of the first 223 markers tested (P = 0.002). We then tested an additional 13 markers and th...

R E Straub, C J MacLean, F A O'Neill, D Walsh, K S Kendler in Molecular Psychiatry (1997)