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A genetic risk score for hypertension is associated with risk of thoracic aortic aneurysm
A genetic risk score (GRS) based on 29 single nucleotide polymorpysms (SNPs) associated with high blood pressure (BP) was prospectively associated with development of hypertension, stroke and cardiovascular ev...
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Open AccessInverse relationship between a genetic risk score of 31 BMI loci and weight change before and after reaching middle age
Genome-wide-association studies have identified numerous body mass index (BMI)-associated variants, but it is unclear how these relate to weight gain in adults at different ages.
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Open AccessIdentification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets
To date, the molecular function of most of the reported type 2 diabetes-associated loci remains unknown. The introduction or removal of cytosine–phosphate–guanine (CpG) dinucleotides, which are possible sites ...
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A common variant upstream of the PAX6 gene influences islet function in man
Impaired glucose tolerance and impaired insulin secretion have been reported in families with PAX6 mutations and it is suggested that they result from defective proinsulin processing due to lack of prohormone con...
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Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study
To study the heritability and familiality of type 2 diabetes and related quantitative traits in families from the Botnia Study in Finland.
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A family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)–Botnia study
We studied the impact of a family history of type 2 diabetes on physical fitness, lifestyle factors and diabetes-related metabolic factors.
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Prediction of postpartum diabetes in women with gestational diabetes mellitus
We studied the incidence of postpartum diabetes after gestational diabetes mellitus and investigated biochemical and clinical predictors of postpartum diabetes.
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4.2 Chromosome 2q12: the Adrenergic Receptor 2b (ADRA2b) Gene and Metabolic Syndrome in Swedish — is there a Link?
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4.3 The V433M Variant of the CYP4F2 is Associated with Ischemic Stroke in Male Swedish Beyond its Effect on Blood Pressure
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Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle
Reduced oxidative capacity of the mitochondria in skeletal muscle has been suggested to contribute to insulin resistance and type 2 diabetes. Moreover, a set of genes influencing oxidative phosphorylation (OXP...
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Polymorphisms in the gene encoding the voltage-dependent Ca2+ channel CaV2.3 (CACNA1E) are associated with type 2 diabetes and impaired insulin secretion
Glucose-stimulated insulin secretion is dependent on the electrical activity of beta cells; hence, genes encoding beta cell ion channels are potential candidate genes for type 2 diabetes. The gene encoding the...
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Impact of the peroxisome proliferator activated receptor-γ coactivator-1β (PGC-1β) Ala203Pro polymorphism on in vivo metabolism, PGC-1β expression and fibre type composition in human skeletal muscle
Peroxisome proliferator activated receptor-γ coactivator-1β (PGC-1β, also known as PPARGC1B) expression is reduced in skeletal muscle from patients with type 2 diabetes mellitus and in elderly subjects. Ala203Pro...
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Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes
Activation of the insulin receptor substrate-1 (IRS1) is a key initial step in the insulin signalling pathway. Despite several reports of association of the G972R polymorphism in its gene IRS1 with type 2 diabete...
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Common variants in HNF-1 α and risk of type 2 diabetes
Mutations in the hepatocyte nuclear factor 1-α gene (HNF-1α, now known as the transcription factor 1 gene [TCF1]) cause the most common monogenic form of diabetes, MODY3, but it is not known if common variants in...
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Common variants in MODY genes increase the risk of gestational diabetes mellitus
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Common variants in MODY genes increase the risk of gestational diabetes mellitus
Impaired beta cell function is the hallmark of gestational diabetes mellitus (GDM) and MODY. In addition, women with MODY gene mutations often present with GDM, but it is not known whether common variants in M...
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Association of the E23K polymorphism in the KCNJ11 gene with gestational diabetes mellitus
Gestational diabetes mellitus (GDM) and type 2 diabetes share a common pathophysiological background, including beta cell dysfunction and insulin resistance. In addition, women with GDM are at increased risk o...
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Diabetes-associated HLA genotypes affect birthweight in the general population
The aim of our study was to test the hypothesis that HLA genotypes conferring risk of diabetes, cord blood autoantibodies, or both are associated with increased birthweight.
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40th EASD Annual Meeting of the European Association for the Study of Diabetes
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Pro-opiomelanocortin gene is associated with serum leptin levels in lean but not in obese individuals
OBJECTIVE: Mutations in the pro-opiomelanocortin and melanocortin 4 receptor genes (POMC and MC4R) cause monogenic obesity, and the POMC locus (2p21) has been linked to leptin levels and body mass index (BMI). We...