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Article
Multi-class classification of breast cancer abnormality using transfer learning
According to the survey of World Health Organization (WHO), in 2020 there are 2.3 million women found with breast cancer and 685,000 deaths in world wide. 81% women get affected with cancer over the age of 50 ...
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Article
Open AccessZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells
Development is generally viewed as one-way traffic of cell state transition from primitive to developmentally advanced states. However, molecular mechanisms that ensure the unidirectional transition of cell fa...
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Article
Exploring the acceptance for e-learning among higher education students in India: combining technology acceptance model with external variables
The concept of e-learning has now become fundamental in student learning process. This concept becomes even more relevant in situations of global crisis such as that arising from COVID-19. Since this pandemic ...
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Article
Wearables can help me learn: A survey of user perception of wearable technologies for learning in everyday life
Wearable devices are a popular class of portable ubiquitous technology. These devices are available in a variety of forms, ranging from smart glasses to smart rings. The fact that smart wearable devices are at...
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Article
Role of Oxygen Vacancies for Mediating Ferromagnetic Ordering in La-Doped MgO Nanoparticles
In present work, we have reported the room temperature ferromagnetism in lanthanum (La)-doped magnesium oxide (MgO) nanoparticles. It has been found that the magnetic character increases with dilute concentrat...
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Article
Assessment of metal contamination and the associated human health risk from dustfall deposition: a study in a mid-sized town in India
It is evident from the past studies that dust fallout is a severe concern due to its impact to urban air quality and public health. This study mainly examines the spatial and seasonal variation of dustfall at ...
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Article
Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development
MicroRNAs (miRNAs) regulate many cellular events during brain development by interacting with hundreds of mRNA transcripts. However, miRNAs operate nonuniformly upon the transcriptional profile with an as yet ...
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Article
Assessment of occupational health exposure to particulate matter around opencast coal mines, India: a case study
Particulate matter concentrations in terms of occupational health, namely inhalable, thoracic, and alveolic, were measured using GRIMM aerosol spectrometer in Basundhara Grajanbahal Area, Sundergarh, India. At...
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Article
Spatio-temporal variations of respirable particles at residential areas located in the vicinity of opencast coal projects, India: a case study
The objective of the study is to investigate spatio-temporal variations of PM10, PM2.5, and PM1 concentrations at seven residential sites, located in the vicinity of opencast coal projects, Basundhara Garjanbahal...
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Article
Clinical significance of cathepsin L and cathepsin B in dilated cardiomyopathy
Dysregulated expression of lysosomal cysteine cathepsins is associated with adverse cardiac remodeling, a characteristic of several cardiovascular diseases. However, the information regarding the role of cyste...
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Article
5-HT2B receptor blockade attenuates β-adrenergic receptor-stimulated myocardial remodeling in rats via inhibiting apoptosis: role of MAPKs and HSPs
Recent studies have proposed the potential role of 5-HT2B receptor (5-HT2BR) blockade in alleviating myocardial dysfunction; hitherto, the regulatory pathway for its protective effect has remained enigmatic. In t...
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Article
Open AccessInhibition of TGF-β by a novel PPAR-γ agonist, chrysin, salvages β-receptor stimulated myocardial injury in rats through MAPKs-dependent mechanism
Pharmacological stimulation of peroxisome proliferator-activated receptor-gamma (PPAR-γ) has been recognized as a molecular switch in alleviating myocardial injury through modulating oxidative, inflammatory an...
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Article
FAT10 and NUB1L bind to the VWA domain of Rpn10 and Rpn1 to enable proteasome-mediated proteolysis
FAT10 is the only ubiquitin-like modifier that can target proteins for degradation by the proteasome in a ubiquitin-independent manner. The degradation of FAT10-linked proteins by the proteasome is strongly ac...
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Article
USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis
The ubiquitin-like modifier FAT10 targets proteins for degradation by the proteasome and is activated by the E1 enzyme UBA6. In this study, we identify the UBA6-specific E2 enzyme (USE1) as an interaction part...