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Article
Open AccessMorin ameliorates myocardial injury in diabetic rats via modulation of inflammatory pathways
High blood glucose levels in diabetes lead to vascular inflammation which accelerates atherosclerosis. Herein, Morin was orally administered in male Wistar rats, at the dose of 40 mg/kg for 28 days, and on the...
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Chapter and Conference Paper
Optimised Round Robin with Virtual Runtime for CPU Scheduling
The Central Processing Unit (CPU) consists of the main circuitry to perform all the operations in a computer. One of the most important operations an Operating System performs is CPU Scheduling, which is resp...
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Chapter
Unveiling the Link of Vitamin D and Diverse Cardiovascular Disorders: Current Status and Future Prospective
Cardiovascular disorders (CVD’s) are the major cause of mortality and morbidity worldwide, mainly among Western countries, despite development and advancement in currently available treatment strategies. Vitam...
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Article
Unintentional Injuries Among Under-five Children in a Rural Area in Delhi
To determine the prevalence of unintentional injuries and its associated factors among under-five children in Rural Delhi.
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Article
Attenuation of ROS-mediated myocardial ischemia–reperfusion injury by morin via regulation of RISK/SAPK pathways
Oxidative stress plays an important role in the pathogenesis of myocardial ischemia–reperfusion (IR) injury. Morin, a bioflavonoid, has demonstrated antioxidant, anti-inflammatory and other diverse pharmacolog...
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Article
Role of MAPK/NF-κB pathway in cardioprotective effect of Morin in isoproterenol induced myocardial injury in rats
Oxidative stress plays a major role in myocardial injury. Morin, a bioflavonoid has known to possess various biological activities in previous studies. Hence, this study evaluated the cardioprotective mechanis...
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Article
Mangiferin attenuates cisplatin-induced acute kidney injury in rats mediating modulation of MAPK pathway
Cisplatin has been confined due to the reported cases of nephrotoxicity. In the present study, an active xanthone, Mangiferin (from Mangifera indica) was investigated for its defensive role in cisplatin-induced n...
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Article
Open AccessProtective effect of mangiferin on myocardial ischemia-reperfusion injury in streptozotocin-induced diabetic rats: role of AGE-RAGE/MAPK pathways
Hyperglycemia induced advanced glycation end products-receptor for advanced glycation end products (AGE-RAGE) activation is thought to involve in the development of cardiovascular disease in diabetics. Activat...
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Article
5-HT2B receptor blockade attenuates β-adrenergic receptor-stimulated myocardial remodeling in rats via inhibiting apoptosis: role of MAPKs and HSPs
Recent studies have proposed the potential role of 5-HT2B receptor (5-HT2BR) blockade in alleviating myocardial dysfunction; hitherto, the regulatory pathway for its protective effect has remained enigmatic. In t...
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Article
Open AccessInhibition of TGF-β by a novel PPAR-γ agonist, chrysin, salvages β-receptor stimulated myocardial injury in rats through MAPKs-dependent mechanism
Pharmacological stimulation of peroxisome proliferator-activated receptor-gamma (PPAR-γ) has been recognized as a molecular switch in alleviating myocardial injury through modulating oxidative, inflammatory an...
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Article
Emblica officinalis Exerts Antihypertensive Effect in a Rat Model of DOCA-Salt-Induced Hypertension: Role of (p) eNOS, NO and Oxidative Stress
Emblica officinalis (EO) has antioxidant properties that could improve redox-sensitive vascular, cardiac and renal changes associated with deoxycorticosterone acetate/1% NaCl high salt (D...
