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  1. No Access

    Article

    Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer

    Co-occurrent KRAS and TP53 mutations define a majority of patients with pancreatic ductal adenocarcinoma (PDAC) and define its pro-metastatic proclivity. Here, we demonstrate that KRAS-TP53 co-alteration is assoc...

    Jashodeep Datta, Anna Bianchi, Iago De Castro Silva, Nilesh U. Deshpande… in Oncogene (2022)

  2. No Access

    Article

    Clinical significance of cathepsin L and cathepsin B in dilated cardiomyopathy

    Dysregulated expression of lysosomal cysteine cathepsins is associated with adverse cardiac remodeling, a characteristic of several cardiovascular diseases. However, the information regarding the role of cyste...

    Siddharth Mehra, Manish Kumar, Mansi Manchanda… in Molecular and Cellular Biochemistry (2017)