8 Result(s)
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Article
Mart Saarma
Cell Biology
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Article
Open AccessAugmenting hematoma-scavenging capacity of innate immune cells by CDNF reduces brain injury and promotes functional recovery after intracerebral hemorrhage
During intracerebral hemorrhage (ICH), hematoma formation at the site of blood vessel damage results in local mechanical injury. Subsequently, erythrocytes lyse to release hemoglobin and heme, which act as neu...
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Open AccessCDNF and MANF regulate ER stress in a tissue-specific manner
Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF) display cytoprotective effects in animal models of neurodegenerative diseases. These endoplasmic reti...
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Open AccessDeficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss
The non-conventional neurotrophic factor mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-resident protein that promotes ER homeostasis. MANF has a cytoprotective fun...
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Open AccessMesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Elevates Stimulus-Evoked Release of Dopamine in Freely-Moving Rats
Neurotrophic factors (NTFs) hold potential as disease-modifying therapies for neurodegenerative disorders like Parkinson’s disease. Glial cell line-derived neurotrophic factor (GDNF), cerebral dopamine neurot...
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Parkinson’s disease: towards better preclinical models and personalized treatments
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Current disease modifying approaches to treat Parkinson’s disease
Parkinson’s disease (PD is a progressive neurological disorder characterized by the degeneration and death of midbrain dopamine and non-dopamine neurons in the brain leading to motor dysfunctions and other sym...
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Expression of GFRα-1, GFRα-2, and c-Ret mRNAs in rat adrenal gland
Glial cell line-derived neurotrophic factor (GDNF), an important factor for develo** and lesioned pre- and postganglionic sympathetic neurons, and its congeners signal through a receptor complex consisting o...
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Expression of the naturally occurring truncated trkB neurotrophin receptor induces outgrowth of filopodia and processes in neuroblastoma cells
We have investigated the effects of the truncated trkB receptor isoform T1 (trkB.T1) by transient transfection into mouse N2a neuroblastoma cells. We observed that expression of trkB.T1 leads to a striking cha...
