54 Result(s)

Article

MiR-124 is differentially expressed in derivatives of the sympathoadrenal cell lineage and promotes neurite elongation in chromaffin cells

The neural-crest-derived sympathoadrenal cell lineage gives rise to sympathetic neurons and to endocrine chromaffin cells of the adrenal medulla. Both cell types express a largely overlap** set of genes, inc...

Stella Shtukmaster, Priyanka Narasimhan, Tehani El Faitwri… in Cell and Tissue Research (2016)

Article

Gdf-15 deficiency does not alter vulnerability of nigrostriatal dopaminergic system in MPTP-intoxicated mice

Growth/differentiation factor−15 (Gdf-15) is a member of the transforming growth factor-β (Tgf-β) superfamily and has been shown to be a potent neurotrophic factor for midbrain dopaminergic (DAergic) neurons b...

Venissa Machado, Ralf Gilsbach, Richa Das, Andreas Schober… in Cell and Tissue Research (2016)

Article

Growth/differentiation factor-15 and its role in peripheral nervous system lesion and regeneration

Growth/differentiation factor-15 (GDF-15) is a distant member of the transforming growth factor beta (TGF-β) superfamily. It is widely distributed in the nervous system, where it has been shown to play an impo...

**aolong Wang, Julia Krebbers, Petar Charalambous… in Cell and Tissue Research (2015)

Article

Role of Transient Receptor Potential Channel 1 (TRPC1) in Glutamate-Induced Cell Death in the Hippocampal Cell Line HT22

Transient receptor potential channel 1 (TRPC1; a cation channel activated by store depletion and/or through an intracellular messenger) is expressed in a variety of tissues, including the brain. To study the p...

K. Lakshmi Narayanan, Srinivasa Subramaniam… in Journal of Molecular Neuroscience (2014)

Article

Neurotrophic molecules in the treatment of neurodegenerative disease with focus on the retina: status and perspectives

Neurotrophic factors are operationally defined as molecules that promote the survival and differentiation of neurons. Chemically, they belong to divergent classes of molecules but most of the classic neurotrop...

Klaus Unsicker in Cell and Tissue Research (2013)

Article

Regulation and effects of GDF-15 in the retina following optic nerve crush

Growth/differentiation factor-15 (GDF-15) is a distant member of the transforming growth factor-β superfamily and is ubiquitously expressed in the central nervous system. It is prominently upregulated in cereb...

Petar Charalambous, **aolong Wang, Solon Thanos… in Cell and Tissue Research (2013)

Article

Local substitution of GDF-15 improves axonal and sensory recovery after peripheral nerve injury

The growth/differentiation factor-15, GDF-15, has been found to be secreted by Schwann cells in the lesioned peripheral nervous system. To investigate whether GDF-15 plays a role in peripheral nerve regenerati...

Leonore Mensching, Ann-Kathrin Börger, **along Wang… in Cell and Tissue Research (2012)

Chapter

Neurotrophic Support of Midbrain Dopaminergic Neurons

In this chapter we review work on neurotrophic factors for midbrain dopaminergic neurons mainly from the past decade, with a focus on neurotrophins and fibroblast growth factors. We summarize data obtained fro...

Oliver von Bohlen, Klaus Unsicker in Development and Engineering of Dopamine Neurons (2009)

Article

GDNF prevents TGF-β-induced damage of the plasma membrane in cerebellar granule neurons by suppressing activation of p38-MAPK via the phosphatidylinositol 3-kinase pathway

Transforming growth factor-β (TGF-β) and glial-cell-line-derived neurotrophic factor (GDNF) have been shown to synergize in several paradigms of neuronal survival. We have previously shown that cerebellar gran...

Srinivasa Subramaniam, Jens Strelau, Klaus Unsicker in Cell and Tissue Research (2008)

Article

The synapse - recent advances

Klaus Unsicker in Cell and Tissue Research (2006)