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  1. Article

    Open Access

    Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Elevates Stimulus-Evoked Release of Dopamine in Freely-Moving Rats

    Neurotrophic factors (NTFs) hold potential as disease-modifying therapies for neurodegenerative disorders like Parkinson’s disease. Glial cell line-derived neurotrophic factor (GDNF), cerebral dopamine neurot...

    Juho-Matti Renko, Susanne Bäck, Merja H. Voutilainen… in Molecular Neurobiology (2018)

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  2. Article

    Open Access

    Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra

    The anti-inflammatory effect of the cerebral dopamine neurotrophic factor (CDNF) was shown recently in primary glial cell cultures, yet such effect remains unknown both in vivo and in 6-hydroxydopamine (6-OHDA) m...

    Rasajna Nadella, Merja H Voutilainen, Mart Saarma… in Journal of Neuroinflammation (2014)

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  3. No Access

    Article

    Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo

    The drugs currently available for Parkinson's disease patients generally treat only the symptoms, and do not prevent the degeneration and death of dopaminergic neurons in the brain, the cause the motor defects...

    Päivi Lindholm, Merja H. Voutilainen, Juha Laurén, Johan Peränen… in Nature (2007)