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Time course of metabolic findings in coronary occlusion and reperfusion and their role for assessing myocardial salvage
The techniques currently used to assess myocardial infarction are limited in their ability to determine the amount of viable myocardium after a temporary ischemic event. Blood flow and segmental function may n...
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Article
Doxorubicin cardiotoxicity: Response of left ventricular ejection fraction to exercise and incidence of regional wall motion abnormalities
Gated radionuclide ventriculograms were performed to evaluate cardiac function in 53 patients who received doxorubicin treatment for various malignancies (mean dose: 449±128 mg/m2 BSA). In fourteen patients (Grou...
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Article
Imaging of metabolism and autonomic innervation of the heart by positron emission tomography
Positron emission tomography (PET) allows, in combination with multiple radiopharmaceuticals, unique physiological and biochemical tissue characterization. Tracers of blood flow, metabolism and neuronal functi...
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Article
The effects of afterload reduction on myocardial carbon 11-labeled acetate kinetics and noninvasively estimated mechanical efficiency in patients with dilated cardiomyopathy
With echocardiography and dynamic carbon 11-labeled acetate (C-11 acetate) positron emission tomographic imaging, C-11 acetate kinetics and a parameter that estimates mechanical ventricular efficiency (the wor...
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Article
Metabolic imaging by positron emission tomography early after myocardial infarction as a predictor of recovery of myocardial function after reperfusion
Myocardial ischemia leads to alterations in myocardial substrate metabolism that have been shown to reflect severity of ischemic injury. The purpose of this study was to correlate oxidative metabolism with rec...
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Article
Comparison of thallium-201 SPECT redistribution patterns and rubidium-82 PET rest-stress myocardial blood flow imaging
To compare regional thallium-201 SPECT redistribution patterns with rubidium-82 PET, we studied 81 patients with both imaging modalities. Sixty patients had significant coronary artery disease. All patients un...
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Article
Interobserver and interstudy variability of myocardial blood flow and flow-reserve measurements with nitrogen 13 ammonia-labeled positron emission tomography
Experimental studies have shown that positron emission tomography (PET) with 13N-labeled ammonia provides accurate quantification of regional myocardial blood flow (MBF) under rest and stress conditions. To estab...
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Article
The role of nitrogen 13 ammonia positron emission tomography in predicting functional outcome after coronary revascularization
We sought to evaluate the predictive value of positron emission tomography (PET) by using blood flow imaging with semiquantitative data analysis techniques for predicting recovery of regional function after re...
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Article
Journal of Nuclear Cardiology Nuclear Cardiology News Update
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Article
Scintigraphic evaluation of cardiac autonomic innervation
Alterations in cardiac autonomic neuronal function have become the focus of intense research in various cardiovascular diseases. Both single-photon emission tomography (SPECT) and the positron emission tomogra...
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Article
Whole-body positron emission tomography in clinical oncology: Comparison between attenuation-corrected and uncorrected images
The clinical need for attenuation correction of whole-body positron emission tomography (PET) images is controversial, especially because of the required increase in imaging time. In this study, regional trace...
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Article
Attenuation-corrected rest thallium-201/stress technetium 99m sestamibi myocardial SPECT in normals
Rest thallium-201/stress technetium 99m sestamibi protocol is widely used in the clinical setting. Although attenuation correction (AC) represents an important recent development in cardiac single photon emiss...
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Article
Regional myocardial wall thickening and global ejection fraction in patients with low angiographic left ventricular ejection fraction assessed by visual and quantitative resting ECG-gated 99mTc-tetrofosmin single-photon emission tomography and magnetic resonance imaging
We investigated the use of visual and quantitative technetium 99m tetrofosmin ECG-gated single-photon emission tomography (SPET) for the assessment of regional myocardial wall thickening (WT) and left ventric...
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Article
Reproducibility of polar map generation and assessment of defect severity and extent assessment in myocardial perfusion imaging using positron emission tomography
The purpose of this study was to determine the reliability of new software developed for the analysis of cardiac tomographic data. The algorithm delineates the long axis and defines the basal plane and subseq...
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Article
Effect on coronary artery flow reserve and resistance in the remote area after acute coronary artery occlusion in the pig model
It has been reported that vasodilator function in remote myocardial regions supplied by “angiographically normal” coronary arteries is impaired in patients after acute myocardial infarction (MI). The aim of th...
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Article
Journal of Nuclear Cardiology Nuclear Cardiology News Update
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Article
Reflections on the fourth international conference of nuclear cardiology in Athens, Greece
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Metaiodobenzylguanidine scintigraphy of the heart: what have we learnt clinically?
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Non-invasive estimation of myocardial efficiency using positron emission tomography and carbon-11 acetate – comparison between the normal and failing human heart
The clearance kinetics of carbon-11 acetate, assessed by positron emission tomography (PET),can be combined with measurements of ventricular function for non-invasive estimation of myocardial oxygen consumptio...
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Article
In vivo imaging of herpes simplex virus type 1 thymidine kinase gene expression: early kinetics of radiolabelled FIAU
Previous studies have shown that the herpes simplex virus type 1 thymidine kinase gene (HSV1-tk), in combination with appropriate radiolabelled substrates (e.g. [I*]-2’-fluoro-2’-deoxy-5-iodo-1-β-d-arabinofuranos...