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Article
Open AccessPreclinical comparison of [177Lu]Lu-rhPSMA-10.1 and [177Lu]Lu-rhPSMA-10.2 for endoradiotherapy of prostate cancer: biodistribution and dosimetry studies
Radiohybrid PSMA-targeted ligands (rhPSMA) have been introduced as a novel platform for theranostic applications. Among a variety of rhPSMA-ligands developed for radioligand therapy, two stereoisomers [177Lu]Lu-r...
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Article
Adjustment for the Age- and Gender-Related Metabolic Changes Improves the Differential Diagnosis of Parkinsonism
Age and gender are the important factors for brain metabolic declines in both normal aging and neurodegeneration, and the confounding effects may influence early and differential diagnosis of neurodegenerative...
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Article
Open AccessDecoding the dopamine transporter imaging for the differential diagnosis of parkinsonism using deep learning
This work attempts to decode the discriminative information in dopamine transporter (DAT) imaging using deep learning for the differential diagnosis of parkinsonism.
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Article
Open AccessProof of concept of a multimodal intravital molecular imaging system for tumour transpathology investigation
Transpathology highlights the interpretation of the underlying physiology behind molecular imaging. However, it remains challenging due to the discrepancies between in vivo and in vitro measurements and diffic...
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Article
Open AccessPromise and challenges of clinical non-invasive T-cell tracking in the era of cancer immunotherapy
In the last decades, our understanding of the role of the immune system in cancer has significantly improved and led to the discovery of new immunotherapeutic targets and tools, which boosted the advances in c...
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Article
Open AccessThere is a world beyond αvβ3-integrin: Multimeric ligands for imaging of the integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1 by positron emission tomography
In the context of nuclear medicine and theranostics, integrin-related research and development was, for most of the time, focused predominantly on 'RGD peptides' and the subtype αvβ3-integrin. However, there a...
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Article
Open AccessCorrelation of in vivo imaging to morphomolecular pathology in translational research: challenge accepted
Correlation of in vivo imaging to histomorphological pathology in animal models requires comparative interdisciplinary expertise of different fields of medicine. From the morphological point of view, there is ...
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Article
Correction to: Multi-scale imaging as an essential tool for precision medicine
An Erratum to this paper has been published: https://doi.org/10.1007/s00259-021-05396-y
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Article
Multi-scale imaging as an essential tool for precision medicine
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Article
Open AccessAuthor Correction: Hyperpolarized 13C pyruvate magnetic resonance spectroscopy for in vivo metabolic phenoty** of rat HCC
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessEffective rational humanization of a PASylated anti-galectin-3 Fab for the sensitive PET imaging of thyroid cancer in vivo
The lack of a non-invasive test for malignant thyroid nodules makes the diagnosis of thyroid cancer (TC) challenging. Human galectin-3 (hGal3) has emerged as a promising target for medical TC imaging and diagn...
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Article
Open AccessMultiparametric PET and MRI of myocardial damage after myocardial infarction: correlation of integrin αvβ3 expression and myocardial blood flow
Increased angiogenesis after myocardial infarction is considered an important favorable prognostic parameter. The αvβ3 integrin is a key mediator of cell-cell and cell-matrix interactions and an important mole...
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Article
Open AccessDiverse metabolic response of cancer cells treated with a 213Bi-anti-EGFR-immunoconjugate
Evaluation of treatment response is among the major challenges in modern oncology. We herein used a monoclonal antibody targeting the EGF receptor (EGFR) labelled with the alpha emitter 213Bi (213Bi-anti-EGFR-MAb...
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Article
Open AccessAutomated synthesis of [18F]Ga-rhPSMA-7/ -7.3: results, quality control and experience from more than 200 routine productions
The radiohybrid (rh) prostate-specific membrane antigen (PSMA)-targeted ligand [18F]Ga-rhPSMA-7 has previously been clinically assessed and demonstrated promising results for PET-imaging of prostate cancer. The l...
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Article
Open AccessHyperpolarized 13C pyruvate magnetic resonance spectroscopy for in vivo metabolic phenoty** of rat HCC
The in vivo assessment of tissue metabolism represents a novel strategy for the evaluation of oncologic disease. Hepatocellular carcinoma (HCC) is a high-prevalence, high-mortality tumor entity often discovere...
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Myocardial Innervation
An important target for cardiac molecular imaging is the autonomic nervous system, which exerts both stimulatory (primarily via sympathetic fibers) and inhibitory (primarily via parasympathetic fibers) effects...
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Article
Open AccessHybrid PET/MR imaging for the prediction of left ventricular recovery after percutaneous revascularisation of coronary chronic total occlusions
To evaluate myocardial viability assessment with hybrid 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/magnetic resonance imaging ([18F]FDG-PET/MR) in predicting left ventricular (LV) wall motion re...
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Article
Correction: 18F-FIBT may expand PET for β-amyloid imaging in neurodegenerative diseases
The author listing has been updated to indicate that Timo Grimmer and Kuangyu Shi are equally contributing authors.
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Article
Open Access18F-FIBT may expand PET for β-amyloid imaging in neurodegenerative diseases
18F-FIBT, 2-(p-Methylaminophenyl)-7-(2-[18F]fluoroethoxy)imidazo-[2,1-b]benzothiazole, is a new selective PET tracer under clinical investigation to specifically image β-amyloid depositions (Aβ) in humans in-vivo...
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Article
Open AccessFirst In-Human Medical Imaging with a PASylated 89Zr-Labeled Anti-HER2 Fab-Fragment in a Patient with Metastatic Breast Cancer
PASylation® offers the ability to systematically tune and optimize the pharmacokinetics of protein tracers for molecular imaging. Here we report the first clinical translation of a PASylated Fab fragment (89Zr∙Df...
