14 Result(s)

Article

Mobilization of peripheral blood stem cells for autologous transplant in non-Hodgkin's lymphoma and multiple myeloma patients by plerixafor and G-CSF and detection of tumor cell mobilization by PCR in multiple myeloma patients

This report describes the first investigational use of plerixafor in Europe and the determination of tumor cell mobilization by polymerase chain-reaction after plerixafor treatment in a subset of patients with...

S Fruehauf, G Ehninger, K Hübel, J Topaly, H Goldschmidt… in Bone Marrow Transplantation (2010)

Article

Occurrence of donor-derived CLL 8 years after sibling donor SCT for CML

J B Perz, M Ritgen, M Moos, A D Ho, M Kneba, P Dreger in Bone Marrow Transplantation (2008)

Article

Lack of CD56 expression on myeloma cells is not a marker for poor prognosis in patients treated by high-dose chemotherapy and is associated with translocation t(11;14)

Lack of CD56 expression was reported to be associated with a poor prognosis in multiple myeloma (MM) patients treated with conventional chemotherapy. Aim of our retrospective study was to analyse whether CD56 ...

M Hundemer, U Klein, D Hose, M-S Raab, F W Cremer, A Jauch… in Bone Marrow Transplantation (2007)

Article

Heparan sulphate proteoglycans are essential for the myeloma cell growth activity of EGF-family ligands in multiple myeloma

The epidermal growth factor (EGF)/EGF-receptor (ErbB1-4) family is involved in the biology of multiple myeloma (MM). In particular, ErbB-specific inhibitors induce strong apoptosis of myeloma cells (MMC) in vitro

K Mahtouk, F W Cremer, T Rème, M Jourdan, M Baudard, J Moreaux, G Requirand… in Oncogene (2006)

Article

Stable mixed chimerism after T cell-depleted allogeneic hematopoietic stem cell transplantation using conditioning with low-dose total body irradiation and fludarabine

Although reduced intensity conditioning (RIC) before allografting is associated with low treatment-related morbidity and mortality, graft-versus-host disease (GVHD) remains a significant complication of hemato...

M Görner, L Kordelas, M Thalheimer, T Luft, S Pfeiffer… in Bone Marrow Transplantation (2002)

Article

Anti-CD20 antibody as consolidation therapy in a patient with primary plasma cell leukemia after high-dose therapy and autologous stem cell transplantation

In multiple myeloma (MM), circulating malignant B cells are proposed as the proliferative compartment of the disease. In view of the close relationship between multiple myeloma and primary plasma cell leukemi...

C. Gemmel, F. Cremer, M. Weis, M. Witzens, G. Moldenhauer… in Annals of Hematology (2002)

Article

Molecular monitoring of the tumor load predicts progressive disease in patients with multiple myeloma after high-dose therapy with autologous peripheral blood stem cell transplantation

The clinical relevance of the assessment of minimal residual disease (MRD) in patients with multiple myeloma (MM) to predict disease recurrence has not been proven. In the present study, we retrospectively ana...

E Lipinski, FW Cremer, AD Ho, H Goldschmidt, M Moos in Bone Marrow Transplantation (2001)

Article

Evaluation of the kinetics of the bone marrow tumor load in the course of sequential high-dose therapy assessed by quantitative PCR as a predictive parameter in patients with multiple myeloma

The aim of this investigation was to examine the possible clinical significance of the kinetics of bone marrow (BM) tumor load during the course of sequential high-dose therapy (HDT) as assessed by quantitativ...

FW Cremer, E Ehrbrecht, K Kiel, A Benner, U Hegenbart, AD Ho… in Bone Marrow Transplantation (2000)

Article

CD19⁺ and CD20⁺ B cells from the peripheral blood of patients with multiple myeloma are not infected with human herpesvirus 8

T Bösing, F Bellos, FW Cremer, C Gemmel, G Moldenhauer, AD Ho, H Goldschmidt… in Leukemia (2000)

Article

Analysis of circulating tumor cells in patients with multiple myeloma during the course of high-dose therapy with peripheral blood stem cell transplantation

In multiple myeloma (MM) circulating CD19⁺ cells have been considered as myeloma precursors. As these cells are also possibly a reservoir of treatment resistant disease evaluation of the CD19⁺ cells during the co...

K Kiel, FW Cremer, C Rottenburger, C Kallmeyer, E Ehrbrecht… in Bone Marrow Transplantation (1999)

Article

The remission status before and the PCR status after high-dose therapy with peripheral blood stem cell support are prognostic factors for relapse-free survival in patients with follicular non-Hodgkin’s lymphoma

It was the aim of our study to examine the clinical significance of t(14;18)-positive cells in samples from 47 patients with follicular non-Hodgkin’s lymphoma (NHL) who underwent high-dose therapy with autolog...

M Moos, R Schulz, S Martin, A Benner, R Haas in Leukemia (1998)

Article

First and second apheresis in patients with multiple myeloma: no differences in tumor load and hematopoietic stem cell yield

Autologous peripheral blood stem cells (PBSC) are now widely used to support myeloablative therapy in patients with multiple myeloma (MM). The presence of malignant cells in these autografts has been demonstra...

K Kiel, FW Cremer, E Ehrbrecht, M Wallmeier, U Hegenbart… in Bone Marrow Transplantation (1998)

Article

Detection of minimal tumor load in blood stem cell autografts in multiple myeloma: Steady-state versus high-dose chemotherapy stem cell mobilization

H. Goldschmidt, M. Moos, F. Cremer… in Journal of Cancer Research and Clinical On… (1995)