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Article
Magnetic shielding and spin-rotation interaction in ground state alkali molecules
Precision measurements of nuclear magnetic dipole moments in alkali molecules are performed using atom-molecule exchange optical pum**. A comparison with measurements on alkali atoms gives the magnetic shiel...
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Article
Mass spectrometric size analysis of N2O-clusters
Mass spectra of N2O-clusters in the size rangen≲7,000 molecules per cluster, formed in a supersonic beam, have been recorded in a time-of-flight mass spectrometer. The spectra trace the transition from growth by ...
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Article
Effects of filaggrin breakdown products on the growth and maturation of keratinocytes
Filaggrin is degraded to amino acids in the stratum corneum. We tested the hypothesis that the resulting high concentrations of amino acids might be involved in the control of keratinocyte maturation. An amino...
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Article
Prevalence of coeliac disease in diabetic children and adolescents
Screening for coeliac disease (CD) with serum antigliadin antibodies (AGA) was performed in 1032 diabetic children and adolescents. In 8 children CD had been diagnosed before study entry. Of the remaining 1024...
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Article
Einfluß von Pestiziden auf die Funktion von Spermatozoen in vitro
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Article
Map** of the gene for autosomal recessive polycystic kidney disease (ARPKD) to chromosome 6p21–cen
Autosomal recessive polycystic kidney disease (ARPKD) is one of the major hereditary nephropathies in children predominantly presenting in early childhood. The clinical picture is variable but there is a fatal...
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Article
Schizophrenia: Shifting the balance of care
Schizophrenia poses a major challenge to policy makers in health and social care in England. As deinstitutionalisation has progressed, public concern about people with the condition has increased owing to a sm...
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Article
Human adenosine A2a receptor (A2aAR) gene: systematic mutation screening in patients with schizophrenia
Several lines of evidence suggest an involvement of adenosine A2a receptor (A2aAR) mediated adenosinergic neuromodulation in the etiopathogenesis of schizophrenia. We therefore perfomed a systematic mutation scan...
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Article
QALYs and mental health care
Quality-adjusted life year measures (QALYs) have been fervently debated by researchers and decision makers concerned with resource allocation in the health care sector. They have been heralded as important aid...
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Article
Systematic mutation screening and association study of the A1 and A2a adenosine receptor genes in panic disorder suggest a contribution of the A2a gene to the development of disease
Several lines of evidence suggest a contribution of adenosinergic neurotransmission to the development of panic disorder. We therefore hypothesized that variation in the A1 and A2a adenosine receptor (AR) genes m...
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Article
Insertion/deletion variant (−141C Ins/Del) in the 5′ regulatory region of the dopamine D2 receptor gene: lack of association with schizophrenia and bipolar affective disorder
A possible dysregulation of dopaminergic neurotransmission has been implicated in the aetiology of schizophrenic psychoses, in particular of paranoid-hallucinatory states, and of the manic episodes of bipolar...
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Article
Does a hostel's managing agency determine the access to psychiatric services of its residents?
This study examines the effect of managing agency (local authority, private or voluntary) on the use of other health and social care services by residents in mental health hostels and group homes with differe...
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Article
Association between hSKCa3 and schizophrenia not confirmed by transmission disequilibrium test in 193 offspring/parents trios
A possible association between the small conductance calcium-regulated potassium channel gene, hSKCa3, and schizophrenia has recently been described by Chandy et al1 using a case-control design with patients with...
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Article
Serotonin transporter gene and schizophrenia: evidence for association/linkage disequilibrium in families with affected siblings
The serotonergic (5-HT) system has been implicated in the etiopathogenesis of psychoses. Since the 5-HT transporter plays an important role in regulation of 5-HT transmission, its gene can be considered as a c...
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Article
DRD4 exon III VNTR polymorphism—susceptibility factor for heroin dependence? Results of a case-control and a family-based association approach
Dopaminergic abnormalities are implicated in the pathogenesis of substance abuse.1 Recently, two reports have been published suggesting an association between opioid dependence and presence of long alleles of the...
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Article
Dopamine D3 receptor variant and tardive dyskinesia
In the search for genetic factors contributing to tardive dyskinesia, dopamine receptor genes are considered major candidates. The dopamine D3 receptor is of primary interest as dopamine D3 receptor knock-out mi...
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Article
Systematic screening for DNA sequence variation in the coding region of the human dopamine transporter gene (DAT1)
The dopamine transporter (DAT) plays a central role in dopaminergic neurotransmission in the human brain. Genetic association studies have used a variable number of tandem repeat (VNTR) polymorphism in the 3′-...
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Article
Association study of the low-activity allele of catechol-O-methyltransferase and alcoholism using a family-based approach
Catechol-O-methyltransferase (COMT) is a major component of the metabolic pathways of neurotransmitters such as dopamine, adrenaline, and noradrenaline. The activity of COMT is known to vary within the populat...
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Article
Risikostratifizierung in der Herzchirurgie bei Patienten im Alter von achtzig Jahren und älter
Outcome nach Herzoperationen hat zunehmend für Herzchirurgen und für die Öffentlichkeit an Bedeutung gewonnen. Qualitätsverbesserungen und Outcome können durch präoperative Risiken stratifiziert werden.¶ Di...
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Article
Lattice parameters and anisotropic thermal expansion of hexagonal boron nitride in the 10–297.5 K temperature range
Lattice parameters for hexagonal boron nitride (hBN) were determined using X-ray powder diffraction at a synchrotron-radiation source (beamline B2, Hasylab/DESY, Hamburg) in the previously uninvestigated temp...
