29 Result(s)
within
English
Oncology
John C. Reed
Article
-
Article
Systematic analysis and validation of differential gene expression in ovarian serous adenocarcinomas and normal ovary
Cancer of the ovary confers the worst prognosis among women with gynecological malignancies, primarily because most ovarian cancers are diagnosed at late stage. Hence, there is a substantial need to develop ne...
-
Article
Salmonella typhimurium engineered to produce CCL21 inhibit tumor growth
Intravenously-applied bacteria tend to accumulate in tumors and can sporadically lead to tumor regression. Systemic administration of attenuated Salmonella typhimurium is safe and has shown no significant adverse...
-
Article
BLOC1S2 interacts with the HIPPI protein and sensitizes NCH89 glioblastoma cells to apoptosis
The HIPPI (HIP-1 protein interactor) protein is a multifunctional protein that is involved in the regulation of apoptosis. The interaction partners of HIPPI include HIP-1 (Huntingtin-interacting protein-1), Ap...
-
Article
Comparison of pharmacokinetic and metabolic profiling among gossypol, apogossypol and apogossypol hexaacetate
To characterize the stability, pharmacokinetics and metabolism of analogs of gossypol, apogossypol and apogossypol hexaacetate to provide a basis for comparison.
-
Article
Drug Insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms
Regulation of cell death pathways is pivotal to cancer development and progression. Much knowledge has been gained from basic research efforts to understand the complex molecular mechanisms that drive cell tur...
-
Article
Molecular and prognostic distinction between serous ovarian carcinomas of varying grade and malignant potential
Profiles of gene transcription have begun to delineate the molecular basis of ovarian cancer, including distinctions between carcinomas of differing histology, tumor progression and patient outcome. However, t...
-
Article
Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates β-catenin activity in a p53-dependent manner
β-Catenin is a potent oncogenic protein whose cytoplasmic accumulation is a frequent event in cancer cells. The level of β-catenin is regulated by two mechanisms: the adenomatous polyposis coli/Axin/glycogen synt...
-
Article
Heat-shock proteins as regulators of apoptosis
Heat-shock proteins are produced in response to different types of stress conditions making cells resistant to stress-induced cell damage. Under normal conditions, heat-shock proteins play numerous roles in ce...
-
Article
Foreword
-
Article
Bcl-2 and Bcl-xL differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24
Subtraction hybridization identified melanoma differentiation associated gene-7, mda-7, in the context of terminally differentiated human melanoma cells. Based on its structure, cytokine-like properties and propo...
-
Article
PG490-mediated sensitization of lung cancer cells to Apo2L/TRAIL-induced apoptosis requires activation of ERK2
Tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) belongs to the family of programmed cell death-inducing cytokines. Apo2L/TRAIL induces apoptosis in a wide variety of tumor cells. Tumor ce...
-
Article
Dysregulation of apoptosis genes in hematopoietic malignancies
Ever since the discovery of Bcl-2 and the elucidation of its role in apoptosis, tremendous interest has arisen in prospects for triggering suicide of malignant cells by exploiting knowledge emerging from apopt...
-
Article
The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells
Human melanoma cells growth arrest irreversibly, lose tumorigenic potential and terminally differentiate after treatment with a combination of fibroblast interferon (IFN-β) and the protein kinase C activator m...
-
Article
Inhibition of the NF-κB transcription factor increases Bax expression in cancer cell lines
The NF-κB transcription factor has been shown to inhibit apoptosis in several experimental systems. We therefore investigated whether the expression of the Bax proapoptotic protein could be influenced by NF-κB...
-
Article
Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator
Bcl-2 family protein including anti-apoptotic (Bcl-2) or pro-apoptotic (Bax) members can form ion channels when incorporated into synthetic lipid bilayers. This contrasts with the observation that Bcl-2 stabil...
-
Article
Effect of p21waf1/cip1 transgene on radiation induced apoptosis in T cells
The cyclin kinase inhibitor p21WAF1/Cip1 is upregulated by the tumor suppressor p53. While p21 is central for the G-1 arrest mediated by p53, it is still unclear if p21 also functions as a downstream effector of ...
-
Article
BAG-1 accelerates cell motility of human gastric cancer cells
BAG-1 is a Hsp70/Hsc70-binding protein that interacts with Bcl-2, Raf-1, steroid hormone receptors, Siah-1, and hepatocyte growth factor (HGF) receptors, implying multiple functions for the BAG-1 protein. Here...
-
Article
Bcl-2 Gene Family and Related Proteins in Mammary Gland Involution and Breast Cancer
The Bcl-2 gene family regulates tissuedevelopment and tissue homeostasis through the interplayof survival and death factors. Family members arecharacterized as either pro-apoptotic or anti-apoptotic, depending...
-
Article
Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore
The molecular mode of action of lonidamine, a therapeutic agent employed in cancer chemotherapy, has been elusive. Here we provide evidence that lonidamine (LND) acts on mitochondria to induce apoptosis. LND p...
-
Article
Bcl-2 family proteins
Bcl-2 family proteins serve as critical regulators of pathways involved in apoptosis, acting to either inhibit or promote cell death. Altered expression of these proteins occurs commonly in human cancers, cont...
