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  1. Article

    Open Access

    Focal adhesions contain three specialized actin nanoscale layers

    Focal adhesions (FAs) connect inner workings of cell to the extracellular matrix to control cell adhesion, migration and mechanosensing. Previous studies demonstrated that FAs contain three vertical layers, wh...

    Reena Kumari, Katharina Ven, Megan Chastney, Shrikant B. Kokate… in Nature Communications (2024)

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  2. No Access

    Article

    Ligand-dependent localization and function of ORP–VAP complexes at membrane contact sites

    Oxysterol-binding protein/OSBP-related proteins (ORPs) constitute a conserved family of sterol/phospholipid-binding proteins with lipid transporter or sensor functions. We investigated the spatial occurrence a...

    Marion Weber-Boyvat, Henriikka Kentala… in Cellular and Molecular Life Sciences (2015)

  3. Article

    Open Access

    Tristetraprolin is a novel regulator of BDNF

    Brain-derived neurotrophic factor (BDNF) regulates multiple biological processes ranging from central nervous system development and function to neuroinflammation and myogenic differentiation and repair. While...

    Anmol Kumar, Kärt Varendi, Johan Peränen, Jaan-Olle Andressoo in SpringerPlus (2014)

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    Article

    Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures

    A previously uncharacterized member of the I-BAR subfamily of BAR-domain proteins, Pinkbar, is expressed in epithelial cells, where it stabilizes planar membrane sheets. Structural, biochemical and mutagenesis...

    Anette Pykäläinen, Malgorzata Boczkowska… in Nature Structural & Molecular Biology (2011)

  5. No Access

    Article

    A molecular network for de novo generation of the apical surface and lumen

    Polarized-membrane trafficking supports the delivery of polarity proteins to discrete plasma-membrane domains, although the interplay between trafficking and polarity pathways is not fully understood. The smal...

    David M. Bryant, Anirban Datta, Alejo E. Rodríguez-Fraticelli… in Nature Cell Biology (2010)

  6. No Access

    Article

    1H, 13C and 15N resonance assignments of the human mesencephalic astrocyte-derived neurotrophic factor

    Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disease, where dopaminergic cells die most prominently in the area of substantia nigra. Neurotrophic factors (NTFs) are secreted proteins, w...

    Maarit Hellman, Johan Peränen, Mart Saarma, Perttu Permi in Biomolecular NMR Assignments (2010)

  7. No Access

    Article

    Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo

    The drugs currently available for Parkinson's disease patients generally treat only the symptoms, and do not prevent the degeneration and death of dopaminergic neurons in the brain, the cause the motor defects...

    Päivi Lindholm, Merja H. Voutilainen, Juha Laurén, Johan Peränen… in Nature (2007)

  8. No Access

    Article

    N-glycans as apical sorting signals in epithelial cells

    IN epithelial Madin–Darby canine kidney (MDCK) cells newly synthesized molecules are sorted in the trans-Golgi network and directly delivered to their apical and basolateral surface destinations1. Sorting is medi...

    Peter Scheiffele, Johan Peränen, Kai Simons in Nature (1995)