23 Result(s)

Article

The ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment

Amplification and overexpression of erbB2/neu proto-oncogene is observed in 20–30% human breast cancer and is inversely correlated with the survival of the patient. Despite this, somatic activating mutations with...

J Turpin, C Ling, E J Crosby, Z C Hartman, A M Simond, L A Chodosh… in Oncogene (2016)

Article

LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer

Deletion of 11q23–q24 is frequent in a diverse variety of malignancies, including breast and colorectal carcinoma, implicating the presence of a tumor suppressor gene at that chromosomal region. We examined a ...

D C T Ong, Y M Ho, C Rudduck, K Chin, W -L Kuo, D K H Lie, C L M Chua, P H Tan… in Oncogene (2009)

Article

No evidence ofChlamydia trachomatis infection in children with wheeze

P. L. Ragunathan, J. W. Gray, A. P. Kenna… in European Journal of Clinical Microbiology … (1995)

Article

Changing causes of septicaemia in paediatric oncology patients: Effect of imipenem use

One hundred and fifty-four episodes of septicaemia occurred in 78 patients on a Paediatric Oncology Unit over 2 years. Septicaemias with Gram-positive bacteria were more common than with Gramnegative organisms...

J. W. Gray, S. J. Pedler, A. W. Craft, J. Kernahan… in European Journal of Pediatrics (1994)

Article

Abstracts for the Tenth International Conference on Brain Tumour Research and Therapy

Tore G. Abrahamsen, Finn Wesenberg, Sverre Mørk, Jeffrey Allen… in Journal of Neuro-Oncology (1993)

Article

Enzymatic production of single-stranded DNA as a target for fluorescence in situ hybridization

This study demonstrates that Exonuclease III (Exo III) can be used to produce sufficient single-stranded (ss)DNA in chromosomes and cells to allow in situ hybridization. In this study, all of the probes were m...

H. van Dekken, D. Pinkel, J. Mullikin, J. W. Gray in Chromosoma (1988)

Article

Stabilization of chromosomes by DNA intercalators for flow karyoty** and identification by banding of isolated chromosomes

A number of structurally unrelated DNA intercalators have been studied as stabilizers of mitotic chromosomes during isolation from rodent and human metaphase cells. Seven out of the nine intercalators tested w...

J. A. Aten, C. H. C. M. Buys, A. Y. van der Veen, J. R. Mesa, L. C. Yu… in Histochemistry (1987)

Article

Monoclonal antibodies and immobilized antibodies

Antibodies in both their free and immobilized state have been the object of considerable industrial and academic interest. A variety of methods are used for preparing and immobilizing antibodies. Applications ...

Robert J. Linhardt, C. W. Abell, R. M. Denney… in Applied Biochemistry and Biotechnology (1987)

Article

The binding kinetics and interaction of DNA fluorochromes used in the analysis of nuclei and chromosomes by flow cytometry

The interactions and binding characteristics of DNA dyes used in the flow cytometric analysis of chromatin were studied using human chromosomes and mouse thymocyte nuclei. The kinetics of dye binding and the r...

G. J. van den Engh, B. J. Trask, J. W. Gray in Histochemistry (1986)

Article

Human Chromosome–Specific DNA Libraries: Construction and Availability

The goal of the National Laboratory Gene Library Project at the Los Alamos and Lawrence Livermore National Laboratories is the production of chromosome–specific human gene libraries and their distribution to t...

M. A. Van Dilla, L. L. Deaven, K. L. Albright, N. A. Allen… in Bio/Technology (1986)

Article

Relationship between surviving clonogenic crypt fraction and animal lethality after cytosine arabinoside (Ara-C) exposure

We have measured animal morbidity and the fraction of clonogenic crypt cells following administration of several doses of Ara-C as an infusion over a 24 h period. A nonlinear relationship between reduction in ...

M. G. Pallavicini, C. R. Ng, J. W. Gray in Virchows Archiv B (1984)

Article

Cloning of genomic sequences from the human Y chromosome after purification by dual beam flow sorting

Human Y chromosomes were purified by dual beam flow sorting from a human x Chinese hamster cell line retaining the Y as the only free human chromosome. DNA was extracted from the Y fraction and cloned into λgt...

C. R. Müller, K. E. Davies, C. Cremer, G. Rappold, J. W. Gray… in Human Genetics (1983)

Article

Flow cytometric characterization of a Chinese hamster x man hybrid cell line retaining the human Y chromosome

A Chinese hamster x man hybrid cell line (CH-Y-VII) was established which retains a free human Y chromosome. Exponentially growing CH-Y-VII cells were arrested with colcemid; metaphase chromosomes were isolate...

C. Cremer, J. W. Gray, H. H. Ropers in Human Genetics (1982)