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Article
Open AccessReplication of functional serotonin receptor type 3A and B variants in bipolar affective disorder: a European multicenter study
Serotonin type 3 receptors (5-HT3) are involved in learning, cognition and emotion, and have been implicated in various psychiatric phenotypes. However, their contribution to the pathomechanism of these disorders...
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Article
Genes Located In and Near the Human Pseudoautosomal Region are Located in the X-Y Pairing Region in Dog and Sheep
We cloned and mapped the dog and/or sheep homologues of two human pseudoautosomal genes CSF2RA and ANT3. We also cloned and mapped dog and/or sheep homologues of STS and PRKX, which are located nearby on the diff...
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Article
Comparative map** of Xp22 genes in hominoids – evolutionary linear instability of their Y homologues
Several genes located within or proximal to the human PAR in Xp22 have homologues on the Y chromosome and escape, or partly escape, inactivation. To study the evolution of Xp22 genes and their Y homologues, we...
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Chapter and Conference Paper
Protein Kinase X: A Novel Human Protein Kinase closely related to the Catalytic Subunit of cAMP-dependent Protein Kinase
The recently isolated gene PRKX encodes a novel type of human protein kinase closely related to the cAMP-dependent protein kinase (cAPK). The hydrophilic protein of about 41 kDa is called Protein Kinase X (Prk...
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Article
Cloning of genomic sequences from the human Y chromosome after purification by dual beam flow sorting
Human Y chromosomes were purified by dual beam flow sorting from a human x Chinese hamster cell line retaining the Y as the only free human chromosome. DNA was extracted from the Y fraction and cloned into λgt...