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Article
Erratum: Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer
Correction to: Oncogene (2016) 35, 691–701; doi:10.1038/onc.2014.469; published online 2 February 2015 Since the online publication of this article we have amended CV Pecot’s name to include the author’s middl...
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Article
Open AccessFunctional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer
The myc oncogene is overexpressed in almost half of all breast and ovarian cancers, but attempts at therapeutic interventions against myc have proven to be challenging. Myc regulates multiple biological proces...
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Article
Prevalence of undernutrition during hospitalisation in a children’s hospital: what happens during admission?
The aim of the study was to compare the prevalence of undernutrition in children on presentation to hospital and on discharge.
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Article
Open AccessEarly Observations by the GOES-13 Solar Extreme Ultraviolet Sensor (EUVS)
NOAA’s GOES-13 satellite, launched in May 2006, includes a new solar sensor, called EUVS (Extreme UltraViolet Sensor), that measures energy fluxes in five broad-band spectral channels that span the region from...
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Article
Effective treatment of vascular endothelial growth factor refractory hindlimb ischemia by a mutant endothelial nitric oxide synthase gene
Gene delivery of angiogenic growth factors is a promising approach for the treatment of ischemic cardiovascular diseases. However, success of this new therapeutic principle is hindered by the lack of critical ...
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Article
Autoimmune pancreatitis: an underdiagnosed condition in Caucasians
Unlike in Japan, autoimmune pancreatitis is uncommon in the Western world, particularly in Europe. We report the first case of a Caucasian male with typical features of autoimmune pancreatitis in the UK. Recog...
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Article
The NOAA Goes-12 Solar X-Ray Imager (SXI) 2. Performance
The Solar X-ray Imager (SXI) was launched on 23 July 2001 on NOAA’s GOES-12 satellite and completed post-launch testing on 20 December 2001. It was brought into operations on 21 January 2003. This paper docume...
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Article
The NOAA Goes-12 Solar X-Ray Imager (SXI) 1. Instrument, Operations, and Data
The Solar X-ray Imager (SXI) was launched 23 July 2001 on NOAA’s GOES-12 satellite and completed post-launch testing 20 December 2001. Beginning 22 January 2003 it has provided nearly uninterrupted, full-disk,...
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Article
Tumor Prevention by 9-Cis-Retinoic Acid in the N-Nitroso-N-Methylurea Model of Mammary Carcinogenesis is Potentiated by the Pineal Hormone Melatonin
Our laboratory has demonstrated that treatment of MCF-7 breast cancer cells with melatonin (Mlt) followed 24 h later with physiological concentrations of all-trans retinoic acid (atRA) results in apoptosis. These...
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Chapter
Melatonin and 9-cis-Retinoic Acid in the Chemoprevention of NMU-induced Rat Mammary Carcinoma
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Article
Melatonin inhibits estrogen receptor transactivation and cAMP levels in breast cancer cells
We have previously demonstrated that the pineal hormone, melatonin, can inhibit the growth of estrogen receptor-alpha (ERα)-positive breast cancer cells and suppress ERα gene transcription. To investigate the ...
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Article
Functional expression of the tellurite resistance determinant from the IncHI-2 plasmid pMER610
The transpositional phage MudI 1734 lacZ was used to construct transcriptional fusions within the plasmid pMJ611, which contains the cloned tellurite resistance (TeR) determinant of the IncHI-2 plasmid pMER610. A...
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Article
Cell adhesion molecules in enteropathic processes
The immune response is successfully activated when cells expressing HLA class II molecules present antigen to T lymphocytes, and specific “accessory” molecules are also expressed on the surfaces of the cells i...
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Chapter
Cell adhesion molecules in autoimmune enteropathy
Adhesion to both haematopoetic and non-haematopoetic cells is an obligatory step in antigen presentation and effector cell function. Intercellular adhesion molecule-1 (ICAM-1) is a cell surface glcoprotein who...
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Chapter
Interleukin 1β production by colonic mucosa from children with Crohn’s disease
Crohn’s disease is a chronic relapsing inflammatory disorder involving the bowel, of unknown aetiology. The disease process involves abnormal cellular and humoral immunological mechanisms (1) and the affected ...
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Article
PROTRACTED DIARRHOEA AND AUTOIMMUNE ENTEROPATHY: A GENERALISED AUTOIMMUNE GUT DISORDER WITH A COMMON HLA HAPLOTYPE
In children with protracted diarrhoea, circulating enterocyte auto-antibodies (Ec Ab's) and an enteropathy, diarrhoea may persist despite therapy. we have examined the colon endoscopically in 17 such patients....
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Chapter
Hormone Receptors and Risk in Breast Cancer
It has long been appreciated that some metastatic breast cancers were susceptible to hormonal influences and would respond to hormonal manipulation. The discovery of steroid hormone receptors in some breast ca...
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Article
Inhibitory effects of the pineal hormone melatonin and underfeeding during the promotional phase of 7,12-dimethylbenzanthracene-(DMBA)-induced mammary tumorigenesis
The effects of melatonin (Mel) and/or underfeeding (30% food restriction) on 7,12-dimethylbenzanthracene (DMBA)-induced mammary tumorigenesis were examined in female Sprague-Dawley rats fed a semipurified diet...
