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  1. No Access

    Article

    The ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment

    Amplification and overexpression of erbB2/neu proto-oncogene is observed in 20–30% human breast cancer and is inversely correlated with the survival of the patient. Despite this, somatic activating mutations with...

    J Turpin, C Ling, E J Crosby, Z C Hartman, A M Simond, L A Chodosh… in Oncogene (2016)

  2. No Access

    Article

    Inhibition of NF-kappa B activity in mammary epithelium increases tumor latency and decreases tumor burden

    The transcription factor nuclear factor kappa B (NF-κB) is activated in human breast cancer tissues and cell lines. However, it is unclear whether NF-κB activation is a consequence of tumor formation or a cont...

    L Connelly, W Barham, H M Onishko, T Sherrill, L A Chodosh, T S Blackwell… in Oncogene (2011)

  3. No Access

    Article

    The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2

    Centrosome amplification (CA) contributes to carcinogenesis by generating aneuploidy. Elevated frequencies of CA in most benign breast lesions and primary tumors suggest a causative role for CA in breast cance...

    X Zeng, F Y Shaikh, M K Harrison, A M Adon, A J Trimboli, K A Carroll, N Sharma… in Oncogene (2010)

  4. No Access

    Article

    Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation

    Overexpression and hyperactivation of the type I insulin-like growth factor receptor (IGF-IR) has been observed in human breast tumor biopsies. In addition, in vitro studies indicate that overexpression of IGF-IR...

    R A Jones, C I Campbell, E J Gunther, L A Chodosh, J J Petrik, R Khokha… in Oncogene (2007)