Skip to main content

29 Result(s)

within Article Remove this filter J. Bartek Remove this filter

previous disabled Page of 2
and

  1. No Access

    Article

    Vegetative propagation of the cactusMamillaria woodsii craig through tissue cultures

    A new method of clonal multiplication is described in a representative from the Cactaceae family, which offers wide experimental and horticultural applications.

    Z. Kolář, J. Bártek, B. Vyskot in Experientia (1976)

  2. No Access

    Article

    Differential expression of keratin 19 in normal human epithelial tissues revealed by monospecific monoclonal antibodies

    Three monospecific monoclonal antibodies (BA16, BA17 and A53—B/A2) recognizing different epitopes of the human keratin 19 were used to determine tissue distribution of this 40 kDa keratin polypeptide. Immunohi...

    J. Bártek, J. Bártková, J. Taylor-Papadimitriou, A. Rejthar… in The Histochemical Journal (1986)

  3. No Access

    Article

    HLA-DR antigens on differentiating human mammary gland epithelium and breast tumours

    The staining pattern of a monoclonal antibody directed to the monomorphic determinant of HLA-DR antigens was examined on sections of human mammary gland tissues at various stages of differentiation as well as ...

    J Bártek, M Petřek, B Vojtěšek, J Bártková, J Kovařík… in British Journal of Cancer (1987)

  4. No Access

    Article

    Secretory component in differentiating normal epithelium, benign lesions and malignancy in the human breast as monitored by monoclonal antibodies

    An immunohistochemical study of the expression of the secretory component (SC) in human mammary gland epithelium at various stages of differentiation, as well as in benign and malignant breast tumours, was und...

    J. Bártek, H. Tlaskalová-Hogenová, Z. Stašková, J. Šimečková, B. Vojtěšek… in Histochemistry (1989)

  5. No Access

    Article

    Keratin 19 expression in the adult and develo** human mammary gland

    In the adult human mammary gland, most of the luminal epithelial cells express keratin 19 (K19+). However, in some small ducts and terminal ductal lobular units where branching would be expected to occur durin...

    J. Bartek, J. Bartkova, J. Taylor-Papadimitriou in The Histochemical Journal (1990)

  6. No Access

    Article

    Establishment and characterization of an immortalized but non-transformed human prostate epithelial cell line: BPH-1

    This report describes the development and characterization of an epithelial cell line (BPH-1) from human prostate tissue obtained by transurethral resection. Primary epithelial cell cultures were immortalized ...

    S. W. Hayward, R. Dahiya, G. R. Cunha… in In Vitro Cellular & Developmental Biology … (1995)

  7. No Access

    Article

    Potential role for concurrent abnormalities of the cyclin D1, p16CDKN2 and p15CDKN2B genes in certain B cell non-Hodgkin’s lymphomas. Functional studies in a cell line (Granta 519)

    Abnormalities of several cell-cycle regulatory genes including cyclin D1, p16CDKN2 and p15CDKN2B have been described in B cell non-Hodgkin’s lymphoma (B-NHL). We describe a new B-NHL cell line (Granta 519), with ...

    DM Jadayel, J Lukas, E Nacheva, J Bartkova, G Stranks, PJJC De Schouwer, D Lens… in Leukemia (1997)

  8. Article

    G1/S control and its deregulation in cancer

    J Bartek, C Lukas, C Sørensen, E Santoni-Rugiu, J Bartkova… in Breast Cancer Research (2000)

    Download PDF (403 KB) View Article

  9. No Access

    Article

    The CHEK2 gene and inherited breast cancer susceptibility

    Checkpoint kinase 2 (CHEK2, Chk2) emerges as an important signal transducer of cellular responses to DNA damage and a candidate tumor suppressor whose defects contribute to molecular pathogenesis of diverse ty...

    H Nevanlinna, J Bartek in Oncogene (2006)

  10. No Access

    Article

    DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours

    MDC1 and 53BP1 are critical components of the DNA damage response (DDR) machinery that protects genome integrity and guards against cancer, yet the tissue expression patterns and involvement of these two DDR a...

    J Bartkova, Z Hořejs̆í, M Sehested, J M Nesland, E Rajpert-De Meyts… in Oncogene (2007)

  11. No Access

    Article

    DNA damage signalling guards against activated oncogenes and tumour progression

    DNA damage response (DDR), the guardian of genomic integrity, emerges as an oncogene-inducible biological barrier against progression of cancer beyond its early stages. Recent evidence from both cell culture a...

    J Bartek, J Bartkova, J Lukas in Oncogene (2007)

  12. No Access

    Article

    The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer

    The ataxia-telangiectasia-mutated (ATM) kinase is a key transducer of DNA damage signals within the genome maintenance machinery and a tumour suppressor whose germline mutations predispose to familial breast c...

    J Tommiska, J Bartkova, M Heinonen, L Hautala, O Kilpivaara, H Eerola… in Oncogene (2008)

  13. No Access

    Article

    Cytokine expression and signaling in drug-induced cellular senescence

    Cellular senescence guards against cancer and modulates aging; however, the underlying mechanisms remain poorly understood. Here, we show that genotoxic drugs capable of inducing premature senescence in normal...

    Z Novakova, S Hubackova, M Kosar, L Janderova-Rossmeislova, J Dobrovolna… in Oncogene (2010)

  14. No Access

    Article

    Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas

    Malignant gliomas, the deadliest of brain neoplasms, show rampant genetic instability and resistance to genotoxic therapies, implicating potentially aberrant DNA damage response (DDR) in glioma pathogenesis an...

    J Bartkova, P Hamerlik, M-T Stockhausen, J Ehrmann, A Hlobilkova, H Laursen… in Oncogene (2010)

  15. Article

    Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia

    Maintaining genomic integrity is critical to avoid life-threatening disorders, such as premature aging, neurodegeneration and cancer. A multiprotein cascade operates at sites of DNA double-strand breaks (DSBs)...

    S S Devgan, O Sanal, C Doil, K Nakamura, S A Nahas… in Cell Death & Differentiation (2011)

    Download PDF (1650 KB) View Article

  16. No Access

    Article

    Multicentric breast cancer: clonality and prognostic studies

    Clonality of multicentric breast cancer has traditionally been difficult to assess. We aimed to assess this using analysis of TP53 status (expression and mutation status). These results were then incorporated ...

    R. Eeles, G. Knee, S. Jhavar, J. Mangion, S. Ebbs… in Breast Cancer Research and Treatment (2011)

  17. Article

    Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1

    53BP1 is a mediator of DNA damage response (DDR) and a tumor suppressor whose accumulation on damaged chromatin promotes DNA repair and enhances DDR signaling. Using foci formation of 53BP1 as a readout in two...

    P Moudry, C Lukas, L Macurek, B Neumann, J-K Heriche… in Cell Death & Differentiation (2012)

    Download PDF (2147 KB) View Article

  18. No Access

    Article

    A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response

    One major challenge in cancer research is to understand the complex interplay between the DNA damage response (DDR), genomic integrity, and tumor development. To address these issues, we analyzed 43 bladder tu...

    T Schepeler, P Lamy, V Hvidberg, J R Laurberg, N Fristrup, T Reinert… in Oncogene (2013)

  19. Article

    The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis

    Oncogenic stimuli trigger the DNA damage response (DDR) and induction of the alternative reading frame (ARF) tumor suppressor, both of which can activate the p53 pathway and provide intrinsic barriers to tumor...

    K Evangelou, J Bartkova, A Kotsinas, I S Pateras, M Liontos… in Cell Death & Differentiation (2013)

    Download PDF (5631 KB) View Article

  20. Article

    Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells

    Glioblastoma-initiating cells (GICs) are self-renewing tumorigenic sub-populations, contributing to therapeutic resistance via decreased sensitivity to ionizing radiation (IR). GIC survival following IR is att...

    M Venere, P Hamerlik, Q Wu, R D Rasmussen, L A Song… in Cell Death & Differentiation (2014)

    Download PDF (1688 KB) View Article
previous disabled Page of 2