12 Result(s)

Article

Markers associated with genomic instability, immunogenicity and immune therapy responsiveness in Metaplastic carcinoma of the breast: Expression of γH2AX, pRPA2, P53, PD-L1 and tumor infiltrating lymphocytes in 76 cases

Metaplastic breast cancer (MpBC) is an aggressive subtype of breast carcinoma that is often resistant to conventional chemotherapy. Therefore, novel treatment strategies are urgently needed. Immune check point...

S. Voutilainen, P. Heikkilä, J. Bartkova, H. Nevanlinna, C. Blomqvist… in BMC Cancer (2022)

Article

Addiction to DUSP1 protects JAK2V617F-driven polycythemia vera progenitors against inflammatory stress and DNA damage, allowing chronic proliferation

Inflammatory and oncogenic signaling converge in disease evolution of BCR–ABL-negative myeloproliferative neoplasms, clonal hematopoietic stem cell disorders characterized by gain-of-function mutation in JAK2 kin...

J. Stetka, P. Vyhlidalova, L. Lanikova, P. Koralkova, J. Gursky, A. Hlusi… in Oncogene (2019)

Article

Cytomegalovirus infection induces a stem cell phenotype in human primary glioblastoma cells: prognostic significance and biological impact

Glioblastoma (GBM) is associated with poor prognosis despite aggressive surgical resection, chemotherapy, and radiation therapy. Unfortunately, this standard therapy does not target glioma cancer stem cells (G...

O Fornara, J Bartek Jr, A Rahbar, J Odeberg, Z Khan… in Cell Death & Differentiation (2016)

Article

SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair

Defining mechanisms that generate intratumour heterogeneity and branched evolution may inspire novel therapeutic approaches to limit tumour diversity and adaptation. SETD2 (Su(var), Enhancer of zeste, Trithorax-d...

N Kanu, E Grönroos, P Martinez, R A Burrell, X Yi Goh, J Bartkova… in Oncogene (2015)

Article

What a ‘Ku’incidence!: parallel discoveries of a new DNA repair factor

M Mistrik, J Bartek in Cell Death & Differentiation (2015)

Article

Radiotherapy-induced plasticity of prostate cancer mobilizes stem-like non-adherent, Erk signaling-dependent cells

Fractionated ionizing radiation combined with surgery or hormone therapy represents the first-choice treatment for medium to high-risk localized prostate carcinoma. One of the main reasons for the failure of r...

L Kyjacova, S Hubackova, K Krejcikova, R Strauss… in Cell Death & Differentiation (2015)

Article

Immortalised breast epithelia survive prolonged DNA replication stress and return to cycle from a senescent-like state

Mammalian cells have mechanisms to counteract the effects of metabolic and exogenous stresses, many of that would be mutagenic if ignored. Damage arising during DNA replication is a major source of mutagenesis...

A Maya-Mendoza, J M Merchut-Maya, J Bartkova, J Bartek, C H Streuli… in Cell Death & Disease (2014)

Article

Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells

Glioblastoma-initiating cells (GICs) are self-renewing tumorigenic sub-populations, contributing to therapeutic resistance via decreased sensitivity to ionizing radiation (IR). GIC survival following IR is att...

M Venere, P Hamerlik, Q Wu, R D Rasmussen, L A Song… in Cell Death & Differentiation (2014)

Article

The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis

Oncogenic stimuli trigger the DNA damage response (DDR) and induction of the alternative reading frame (ARF) tumor suppressor, both of which can activate the p53 pathway and provide intrinsic barriers to tumor...

K Evangelou, J Bartkova, A Kotsinas, I S Pateras, M Liontos… in Cell Death & Differentiation (2013)

Article

Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1

53BP1 is a mediator of DNA damage response (DDR) and a tumor suppressor whose accumulation on damaged chromatin promotes DNA repair and enhances DDR signaling. Using foci formation of 53BP1 as a readout in two...

P Moudry, C Lukas, L Macurek, B Neumann, J-K Heriche… in Cell Death & Differentiation (2012)

Article

Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia

Maintaining genomic integrity is critical to avoid life-threatening disorders, such as premature aging, neurodegeneration and cancer. A multiprotein cascade operates at sites of DNA double-strand breaks (DSBs)...

S S Devgan, O Sanal, C Doil, K Nakamura, S A Nahas… in Cell Death & Differentiation (2011)

Article

G1/S control and its deregulation in cancer

J Bartek, C Lukas, C Sørensen, E Santoni-Rugiu, J Bartkova… in Breast Cancer Research (2000)