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Article
Urine DNA biomarkers for hepatocellular carcinoma screening
Hepatocellular carcinoma (HCC) occurs in a well-defined high-risk patient population, but better screening tests are needed to improve sensitivity and efficacy. Therefore, we investigated the use of urine circ...
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Article
Open AccessHydrogen peroxide inducible clone-5 sustains NADPH oxidase-dependent reactive oxygen species-c-jun N-terminal kinase signaling in hepatocellular carcinoma
Target therapy aiming at critical molecules within the metastatic signal pathways is essential for prevention of hepatocellular carcinoma (HCC) progression. Hic-5 (hydrogen peroxide inducible clone-5) which be...
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Article
Reactive oxygen species-mediated PKC and integrin signaling promotes tumor progression of human hepatoma HepG2
The poor prognosis and recurrence of HCC are majorly caused by intrahepatic metastasis. Delineating the molecular pathways mediating these processes may benefit develo** effective targeting therapies. Using ...
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Article
Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species
Signal transduction exerted by the microenvironment around the primary tumor locus may trigger tumor metastasis especially at the migration stage. Sustained mitogen activated protein kinase (MAPK) signaling in...