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  1. No Access

    Article

    E2F-1, Skp2 and cyclin E oncoproteins are upregulated and directly correlated in high-grade neuroendocrine lung tumors

    The transcription factor E2F-1 plays a crucial role in the control of cellular growth. We previously reported its differential pattern of expression in human lung tumors. In this study, we have investigated th...

    C Salon, G Merdzhanova, C Brambilla, E Brambilla, S Gazzeri, B Eymin in Oncogene (2007)

  2. No Access

    Article

    Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers

    Cancer cells frequently express genes normally active in male germ cells. ATAD2 is one of them encoding a conserved factor harbouring an AAA type ATPase domain and a bromodomain. We show here that ATAD2 is highly...

    C Caron, C Lestrat, S Marsal, E Escoffier, S Curtet, V Virolle, P Barbry… in Oncogene (2010)

  3. No Access

    Article

    The transcription factor E2F1 and the SR protein SC35 control the ratio of pro-angiogenic versus antiangiogenic isoforms of vascular endothelial growth factor-A to inhibit neovascularization in vivo

    The transcription factor E2F1 has a crucial role in the control of cell growth and has been shown to regulate neoangiogenesis in a p53-dependent manner through inhibition of activity of the VEGF-A (vascular en...

    G Merdzhanova, S Gout, M Keramidas, V Edmond, J-L Coll, C Brambilla… in Oncogene (2010)

  4. No Access

    Article

    Sumoylation of ING2 regulates the transcription mediated by Sin3A

    ING2 (inhibitor of growth 2) is a candidate tumor-suppressor gene involved in cell cycle control, apoptosis and senescence. Although the functions of ING2 within the chromatin remodeling complex Sin3A/histone ...

    D Ythier, D Larrieu, R Binet, O Binda, C Brambilla, S Gazzeri, R Pedeux in Oncogene (2010)