18 Result(s)
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Article
R-Deprenyl: Pharmacological Spectrum of its Activity
Deprenyl has been discovered by Knoll and co-workers. The R-enantiomer of deprenyl (selegiline) is a selective and irreversible inhibitor of the B-isoform of monoamine oxidase (MAO-B) enzyme. Due to its dopamine ...
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Cytoprotective effect of (−)-deprenyl, (−)desmethyl-deprenyl and (−)deprenyl-N-oxide on glutathione depleted A-2058 melanoma cells
Postulated cytoprotective action of (−)-deprenyl (D), (−)-desmethyl-deprenyl (DD) and (−)-deprenyl-N-oxide (DNO) on l-buthionine-(S,R)-sulfoximine (BSO) toxicity was investigated using in vitro cultures of serum-...
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Cathepsin B-independent abrogation of cell death by CA-074-OMe upstream of lysosomal breakdown
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Article
Open AccessEffect of a novel somatostatin analogue combined with cytotoxic drugs on human tumour xenografts and metastasis of B16 melanoma
A novel somatostatin analogue, TT-232 (which inhibits the proliferation of various cell cultures and transplantable mouse tumours), was examined regarding its effect on human melanoma and lymphoma xenografts a...
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Open AccessAntitumor effect of lysine-isopeptides
Isopeptides (ε-peptides) of lysine, with a given Mw and low polydispersity (10–400 units), were synthesized to study the relationship between their chemical structure and biological effect. The designed compou...
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Article
Apoptosis in Various Organs of Preterm Infants: Histopathologic Study of Lung, Kidney, Liver, and Brain of Ventilated Infants
Apoptosis, the well-characterized form of active programmed cell death, is a physiologic phenomenon in embryonal and fetal life in develo** organs. Severe hypoxia, which occurs in most preterm infants, also ...
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Programmed cell death in Datura innoxia Mill. callus cultures cultivated in light and in dark
It has been established that dimedone in solid culture medium influencedthe growth of Datura innoxia Mill. callus tissues and theapoptotic processes of cells. This formaldehyde (HCHO) capture reagent appearsto mo...
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Article
Anti-apoptotic and apoptotic action of (2)-deprenyl and its metabolites
The mode of cytoprotective action of the monoamine oxydase B inhibitor (−)-deprenyl was studied using A-2058 human melanoma cells in culture. Serum deprivation caused apoptosis of the cultured cells, which co...
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Open AccessAntagonists of growth hormone-releasing hormone (GH-RH) inhibit IGF-II production and growth of HT-29 human colon cancers
Insulin-like growth factors (IGFs) I and II are implicated in progression of various tumours including colorectal carcinomas. To interfere with the production of IGFs, we treated male nude mice bearing xenogra...
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Determination of Endogenous Formaldehyde in Plants (Fruits) Bound to L-Arginine and its Relation to the Folate Cycle, Photosynthesis and Apoptosis
A very powerful nucleophilic reagent, hydralazine(l-hydrazino-phtalazine) proved to be suitable for determination of the endogenous formaldehyde level in biological samples. It was found that in different plan...
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Article
Formaldehyde Cycle and the Natural Formaldehyde Generators and Capturers
S-adenosyl-L-methionine serves as a methyl donor in virtually all of the vast number of enzymatic transmethylation reactions including DNA methylation. On the basis of our former experiences we questioned the ...
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Article
Modification of pathobiological events by potential hepatopharmacological agents
The elucidation of the pathobiological events in chronic liver diseases-such as cellular injury, cell proliferation, remodelling of extracellular matrix — has considerable importance for establishing the ratio...
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Article
Inhibition of two-step urinary bladder carcinogenesis by the somatostatin analogue RC-160
Fisher 344 female rats were exposed for 4 weeks to the initiator carcinogen N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) 0.05% in the drinking water and thereafter to the promoter carcinogen mitomycin C (0.08 mg ...
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Article
Protective effects of D-Trp6-luteinising hormone-releasing hormone microcapsules against cyclophosphamide-induced gonadotoxicity in female rats
The possible protective effect of an agonist of luteinising hormone-releasing hormone (LH-RH) against the ovarian damage caused by cyclophosphamide was investigated in rats. D-Trp6-LH-RH microcapsules were inj...
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Article
The effect of E-N-l-trimethyllysine (TML) on the humoral and cellular immune response
E-N-l-Trimethyllysine glutamate (TML) influences the humoral and cellular immune response of mice. Chronic pre- and post-treatment (100 mg/kg/day, 5 times) transitionally increased the anti-SRBC haemagglutinin t...
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Article
Studies on in vitro carcinogenesis
The incorporation of radioactive labelled Methylcholanthrene into CBA/T6T6 mouse embryonic fibroblast cultures was studied by using light and electronmicroscopic autoradiographic and also liquid scintillation cou...
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Article
A Transferable “Resistance Factor” from in vitro Cultured MDMS-Resistant Yoshida Sarcoma Cells
Cells of the methylene dimethanesulphonate-(MDMS)-resistant Yoshida sarcoma cell line contain a low molecular weight “resistance factor” which is present in the culture medium of these cells and may be utilize...
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Article
Tumour-inducing Effect of Hydrazine in Mice
AFTER the discovery of the experimental tumour-inducing effect of isonicotinic acid hydrazide1 several later investigations verified that this compound showed carcinogenic effects in white mice of different inbre...
