43 Result(s)

Article

Suitability of cisplatin solutions for 14-day continuous infusion by ambulatory pump

The stability of cisplatin (DDP) solutions (1 and 1.6 mg/ml in saline-mannitol) in plastic infusion bags was studied for up to 14 days at 25° C, 37° C and 60° C. Small changes in the solution were observed, bu...

M. Hrubiško, A. T. Mc Gown, J. A. Prendiville… in Cancer Chemotherapy and Pharmacology (1992)

Article

Effect of verapamil on daunorubicin accumulation in lymphocytes isolated from patients undergoing chemotherapy

Verapamil was shown to be capable of increasing intracellular daunorubicin levels in normal lymphocytes isolated from patients undergoing chemotherapy for epithelial ovarian cancer. The extent of the increase ...

A. T. McGown, D. Murphy, D. Crowther, B. W. Fox in Cancer Chemotherapy and Pharmacology (1991)

Article

An autoradiographic study of the intrarenal localisation and retention of cisplatin, iproplatin and paraplatin

The intrarenal localisation of platinum following the intravenous administration of platinum-195m-labelled cisplatin, iproplatin and paraplatin was studied using autoradiography. Following injection of cisplat...

C. Ewen, A. Perera, J. H. Hendry, C. A. McAuliffe… in Cancer Chemotherapy and Pharmacology (1988)

Chapter and Conference Paper

Mechanisms of Drug Resistance in Screening

Resistance is a term which should only properly be applied to a single cell. It is the description of the sensitivity which a single cell exhibits towards a drug, applying particularly to the case where the se...

B. W. Fox in Human Tumour Xenografts in Anticancer Drug Development (1988)

Article

Comparative studies of DNA cross-linking reactions following methylene dimethanesulphonate and its hydrolytic product, formaldehyde

The technique of alkaline elution was employed to study the interactions of methylene dimethane sulphonate (MDMS) and formaldehyde (HCHO) with DNA from Yoshida lymphosarcoma cells treated with these agents. MD...

P. M. O'Connor, B. W. Fox in Cancer Chemotherapy and Pharmacology (1987)

Article

Cross-linking between histones and DNA following treatment with a series of dimethane sulphonate esters

The cross-linking on the nucleohistone to the associated DNA by a series of methaneusulphonates of the busulphan series (CH₃SO₂O(CH₂) _n OSO₂CH₃) from n=4–9 has been studied by ge...

J. A. Hartley, B. W. Fox in Cancer Chemotherapy and Pharmacology (1986)

Article

In vivo distribution studies of radioactively labelled platinum complexes; cis-dichlorodiammine platinum(II), cis-trans-dichlorodihydroxy-bis-(isopropylamine) platinum (IV), cis-dichloro-bis-cyclopropylamine platinum(II), and cis-diammine 1,1-cyclobutanedicarboxylate platinum(II) in patients with malignant disease, using a gamma camera

The in vivo distribution in man of the four platinum derivatives cis-dichlorodiammine platinum(II) (DDP), cis-trans-dichlorodihydroxy-bis-(isopropylamine) platinum (IV) (CHIP), cis-dichloro-bis-cyclopropylamin...

S. E. Owens, N. Thatcher, H. Sharma, N. Adam… in Cancer Chemotherapy and Pharmacology (1985)

Article

Anticancer and Interferon Agents: Synthesis and Properties - Drugs and Parmacutical Sciences - Vol. 24

B.W Fox in British Journal of Cancer (1985)

Article

Anticancer and Interferon Agents: Synthesis and Properties - Drugs and Parmacutical Sciences - Vol. 24

B.W Fox in British Journal of Cancer (1985)

Chapter

Principles of Chemotherapy

The principles underlying the administration of cytotoxic drugs for the treatment of malignant disease differ fundamentally from those of bacterial, fungal, or antiviral infections in that it is not possible t...

P. M. Wilkinson, B. W. Fox in The Radiotherapy of Malignant Disease (1985)

Article

Molecular aspects of anti-cancer drug action Topics in molecular and structural biology

B.W Fox in British Journal of Cancer (1984)

Chapter

Dialkanesulphonates and Chromatin

It was recognised by Finley and co-workers in 1964 (1) that the dialkanesulphonates were a potent group of antitumour agents which, in some but not all cases, also produced a bone marrow depressant action. The...

B. W. Fox, P. Bedford, J. Hartley in Cancer Chemotherapy and Selective Drug Development (1984)

Chapter

Mechanisms of Resistance to Anticancer Agents

Resistance to antitumor agents has been known to occur within tumour tissue since its discovery by Burchenal and his colleagues in 1950. Its meaning in the experimental laboratory may differ from that in the c...

B. W. Fox in Cancer Chemotherapy and Selective Drug Development (1984)

Article

Blood clearance of radioactively labelled cis-diammine 1,1-cyclobutane dicarboxylate platinum(II) (CBDCA) in cancer patients

The blood and urinary clearances of cis-diammine 1,1-cyclobutane dicarboxylate platinum(II) (CBDCA, JM8) were determined in four patients with malignancy. A 40 μCi iv injection of ¹⁹¹Pt/¹⁹³Pt (3:1)-labelled CBDCA...

H. Sharma, N. Thatcher, J. Baer, A. Zaki, A. Smith… in Cancer Chemotherapy and Pharmacology (1983)

Article

A comparative study of the distribution in the male rat of platinum-labelled cis-dichlorodiammine platinum (II), cis-trans-dichlorodihydroxy-bis-(isopropylamine) platinum (I), and cis-dichloro-bis-cyclopropylamine platinum (II)

Three platinum derivatives, cis-dichlorodiammine platinum (II), (DDP), cis-trans-dichlorodihydroxy-bis-(isopropylamine)platinum (IV) (CHIP) and cis-dichloro-bis-cyclopropylamine platinum (II) (CP), have been p...

R. Harrison, C. A. McAuliffe, A. Zaki, J. Baer… in Cancer Chemotherapy and Pharmacology (1983)

Article

Blood clearance of three radioactively labelled platinum complexes: cis-dichlorodiammine platinum II, cis, trans-dichlorodihydroxy-bis-(isopropylamine) platinum IV, and cis-dichloro-bis-cyclopropylamine platinum II, in patients with malignant disease

The blood clearances of three platinum compounds, cis-dichlorodiammine platinum II (DDP), cis, trans-dichlorodihydroxy-bis-(isopropylamine) platinum IV (CHIP), and cis-dichloro-bis-cyclopropylamine platinum II...

N. Thatcher, H. Sharma, R. Harrison, A. Smith… in Cancer Chemotherapy and Pharmacology (1982)

Article

Effects of Drugs on the Cell Nucleus

B W Fox in British Journal of Cancer (1980)

Article

Mitomycin C. Current Status and Developments

B W Fox in British Journal of Cancer (1980)

Article

Moulds, Toxins and Food

B W Fox in British Journal of Cancer (1980)