Abstract
AFTER the discovery of the experimental tumour-inducing effect of isonicotinic acid hydrazide1 several later investigations verified that this compound showed carcinogenic effects in white mice of different inbred strains when administered intraperitoneally or orally over a long period2–8. According to Mori et al.9, the carbamyl group is responsible for the cancerogenic effect of isonicotinic acid hydrazide. On the other hand, Biancifiori et al.3 are of the opinion that the hydrazine radical10 detached from the compound during the metabolic process plays a part in producing tumours. They found in their experiments that the frequency of tumours in mice of BALB/c strain caused by isonicotinic acid hydrazide or hydrazine sulphate was very high, while isonicotinic acid alone showed no carcinogenic effect.
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JUHÁSZ, J., BALÓ, J. & SZENDE, B. Tumour-inducing Effect of Hydrazine in Mice. Nature 210, 1377 (1966). https://doi.org/10.1038/2101377a0
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DOI: https://doi.org/10.1038/2101377a0
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