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Article
25th Anniversary of Pathology Oncology Research
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Article
Richter's and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation-induced cytidine deaminase and aberrant somatic hypermutation
Chronic lymphocytic leukemia (CLL) is an indolent B-cell non-Hodgkin's lymphoma that may transform into higher-grade lymphoma. The transformation involves an increased number of prolymphocytic cells, termed pr...
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Article
Clonal selection in the bone marrow involvement of follicular lymphoma
To characterize the pathways of bone marrow (BM) involvement of follicular lymphoma (FL), we performed morphological and immunophenotypical analysis of tumor cells from lymph nodes (LNs) and corresponding BMs ...
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Article
Cathepsin B-independent abrogation of cell death by CA-074-OMe upstream of lysosomal breakdown
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Article
Relationship between the mutational status of VH genes and pathogenesis of diffuse large B-cell lymphoma in Richter's syndrome
Patients with chronic lymphocytic leukemia (CLL) may develop diffuse large B-cell lymphoma (DLBL), also known as Richter's syndrome. Mutational status of immunoglobulin (Ig) heavy-chain variable region (VH) genes...
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Article
Hypermethylation of the gene promoter and enhancer region can regulate Fas expression and sensitivity in colon carcinoma
Expression of the cell surface receptor Fas is frequently lost or decreased during tumor progression in human colon carcinomas. The methylation status of a 583 bp CpG-rich region within the Fas promoter (−575 ...
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Article
Ultrastructural localization and internalization of proteoglycan epitopes in a human non-Hodgkin (B) lymphoma
In a human non-Hodgkin (B) lymphoma xenograft (HT-117) heparan sulphate (HS) proved to be the main cell surface glycosaminoglycan, in contrast to the chondroitin sulphate dominance in normal lymphoid cells. Us...
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Article
Two human melanoma xenografts with different metastatic capacity and glycosaminoglycan pattern
Two human melanoma xenografts were compared with respect to their in vivo growth and metastatic potentials as well as glycosaminoglycan patterns. The less differentiated HT 168 tumor showed faster growth at pr...
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Chapter and Conference Paper
Xenografted Human Tumors in Preclinical Drug Design
More than 100 human tumors were transplanted into artificially immunosuppressed CBA mice with an overall success rate of 24% (16% colorectal carcinoma, 22% renal cell carcinoma, 12% NHL etc.). These tumor pane...
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Article
Comparative study on Lewis lung tumor lines with ‘low’ and ‘high’ metastatic capacity. II. Cytochemical and biochemical evidence for differences in glycosaminoglycans
The enhanced metastatic capacity of an in vivo selected Lewis lung tumor line (LLT-HH) was correlated with changes in cell-associated glycosaminoglycans (GAG) using ultrastructural cytochemistry, flow cytometry a...
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Article
Antitumor action of N-(2-chloroethyl)-N-nitrosocarbamoyl derivatives of biologically active polypeptide hormone fragments
The antitumor action of the 2-chloroethylnitrosocarbamoyl derivatives of peptides related to the 9–13 amino acid residues of α-MSH/ACTH and of the C-terminal tetrapeptide analogue of gastrin have been investig...
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Chapter
Differences in Cell Surface Characteristics of Poorly and Highly Metastatic Lewis Lung Tumor Variants
The acquisition of invasive and metastatic phenotypes in a transformed cell population is the key event in tumor development and progression. The animal and human neoplasms are characterized by a wide diversit...
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Article
Flow cytometric measurements and electron microscopy of cell surface glycosaminoglycans using Acridine Orange
Cell surface glycosaminoglycans (GAGs) were measured, after various treatments, by their binding to Acridine Organge using flow cytometry. Using a critical electrolyte concentration and combining it with speci...
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Article
Experimental model for liver metastasis formation using lewis lung tumor
A new experimental model is introduced for liver metastases using intrasplenically injected Lewis lung tumor cells. The appearance of liver metastases was studied in the presence and after the removal of prima...
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Article
HBsAg-like structures in immunosuppressed mice inoculated with human hepatitis B virus
Thymectomised and irradiated DBA/2 mice were injected intraperitoneally with human serum containing high titer of HBsAg, and were positive for HBsAg. Through the entire experiment neither degenerative and infl...
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Article
Electronmicroscopical detection of iota-Carrageenan as its ruthenium red complex
Specific detection of iota-Carrageenan (i-CAR) at the ultrastructural level has been obtained by coupling with ruthenium red (RR) — an electron microscopic stain. The i-CAR-RR complex showed electron density o...
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Article
Effect of combined surgical and chemotherapeutic treatment on Lewis lung carcinoma
The effect of combined surgical and chemotherapeutic treatment on Lewis lung carcinoma was studied. The i.m. implanted primary tumor was removed on the 10th day after transplantation, and the survival of mice ...
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Chapter
Theoretical Bases for Designing Combination Therapy with Dibromodulcitol (DBD)
From the results of clinical and experimental tumour chemotherapy it seems that no single agent seems to be able to deal effectively with most of the human tumours and reasonable therapeutic results can only b...
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Article
Studies on in vitro carcinogenesis
The incorporation of radioactive labelled Methylcholanthrene into CBA/T6T6 mouse embryonic fibroblast cultures was studied by using light and electronmicroscopic autoradiographic and also liquid scintillation cou...
