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Article
Open AccessA medical nutriment has supportive value in the treatment of colorectal cancer
MSC (Avemar) is a medical nutriment of which preclinical and observational clinical studies suggested an antimetastatic activity with no toxicity. This open-label cohort trial has compared anticancer treatment...
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Article
Modification of pathobiological events by potential hepatopharmacological agents
The elucidation of the pathobiological events in chronic liver diseases-such as cellular injury, cell proliferation, remodelling of extracellular matrix — has considerable importance for establishing the ratio...
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Chapter
Modification of Pathobiological Events by Potential Hepatopharmacological Agents
The elucidation of the pathobiological events in chronic liver diseases — such as cellular injury, cell proliferation, remodelling of extracellular matrix — has considerable importance for establishing the rat...
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Article
The biological activity of cisplatin and dibromodulcitol in combination therapy
The efficacy and modes of action of dibromodulcitol (DBD) and cisplatin (CDDP) were studied in several model systems. Combination treatments produced a longer survival time in mice bearing P388 solid lymphomas...
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Article
Inhibition of two-step urinary bladder carcinogenesis by the somatostatin analogue RC-160
Fisher 344 female rats were exposed for 4 weeks to the initiator carcinogen N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) 0.05% in the drinking water and thereafter to the promoter carcinogen mitomycin C (0.08 mg ...
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Article
Cytometric analysis of DNA replication inhibited by emetime and cyclosporin A
DNA staining methods based on aspecific interactions with dye molecules have been replaced by an immunofluorescent approach to measure DNA replication. Biotin-11-dUTP was incorporated into permeable thymocytes...
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Article
Interaction between elastin and tumor cell lines with different metastatic potential; in vitro and in vivo studies
Interactions between the extracellular matrix macromolecules and tumor cells are critical in the process of metastasis formation. We show here that elastins (both mature insoluble elastin and a 75-kDa soluble ...
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Article
Ultrastructure of invasion in different tissue types by lewis lung tumour variants
Ultrastructural studies on the interactions of low and highly metastatic 3LL tumour lines with the basement membranes (BMs) of capillaries, veins, muscles, nerves and adipose tissue were performed by injecting...
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Article
Intrasellar hamartoma associated with pituitary adenoma
The histological, ultrastructural and immunocytochemical features are reported of an intrasellar neuronal and lipomatous hamartoma associated with pituitary growth hormone (GH) cell adenoma and acromegaly. Ele...
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Article
Two human melanoma xenografts with different metastatic capacity and glycosaminoglycan pattern
Two human melanoma xenografts were compared with respect to their in vivo growth and metastatic potentials as well as glycosaminoglycan patterns. The less differentiated HT 168 tumor showed faster growth at pr...
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Article
Comparative study on Lewis lung tumour lines with ‘low’ and ‘high’ metastatic capacity III. Glycosaminoglycan synthesis, transport and degradation in cell lines
The glycosaminoglycans (GAGs) of low (LM) and highly metastatic (HM) cell lines of the Lewis lung tumour (3LL) were compared using [3H]glucosamine labelling techniques. The GAGs isolated from nuclei, cytoplasm, p...
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Article
The barrier-like role of activated connective tissue against the spread of supraglottic laryngeal carcinoma
Light microscopic investigations of whole organ serial sections of 15 laryngectomy specimens with supraglottic carcinomas and comparative electron microscopic studies of the upper and lower poles of the tumors...
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Chapter and Conference Paper
Xenografted Human Tumors in Preclinical Drug Design
More than 100 human tumors were transplanted into artificially immunosuppressed CBA mice with an overall success rate of 24% (16% colorectal carcinoma, 22% renal cell carcinoma, 12% NHL etc.). These tumor pane...
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Article
Endothelialization of embolized tumor cells during metastasis formation
The reaction of the endothelial barrier to tumor cell extravasation has been studied using electron microscopy. The model system was pulmonary metastases produced by intravenous injection of B16-F10 melanoma c...
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Article
Late abstracts 186–187
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Article
Comparative study on Lewis lung tumor lines with ‘low’ and ‘high’ metastatic capacity. II. Cytochemical and biochemical evidence for differences in glycosaminoglycans
The enhanced metastatic capacity of an in vivo selected Lewis lung tumor line (LLT-HH) was correlated with changes in cell-associated glycosaminoglycans (GAG) using ultrastructural cytochemistry, flow cytometry a...
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Chapter and Conference Paper
Enzyme Pattern Changes in Preneoplastic and Neoplastic Lesions of the Liver
Primary hepatocellular carcinoma (PHC) is one of the ten most common cancers in the world (Editorial 1983) and one of the most fatal of all malignancies. The incidence of PHC is growing even in the so-called l...
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Article
Antitumor action of N-(2-chloroethyl)-N-nitrosocarbamoyl derivatives of biologically active polypeptide hormone fragments
The antitumor action of the 2-chloroethylnitrosocarbamoyl derivatives of peptides related to the 9–13 amino acid residues of α-MSH/ACTH and of the C-terminal tetrapeptide analogue of gastrin have been investig...
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Chapter
Differences in Cell Surface Characteristics of Poorly and Highly Metastatic Lewis Lung Tumor Variants
The acquisition of invasive and metastatic phenotypes in a transformed cell population is the key event in tumor development and progression. The animal and human neoplasms are characterized by a wide diversit...
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Article
Flow cytometric measurements and electron microscopy of cell surface glycosaminoglycans using Acridine Orange
Cell surface glycosaminoglycans (GAGs) were measured, after various treatments, by their binding to Acridine Organge using flow cytometry. Using a critical electrolyte concentration and combining it with speci...
